Nickel‐Catalyzed Asymmetric Hydrogenation of α‐Substituted Vinylphosphonates and Diarylvinylphosphine Oxides
作者:Hanlin Wei、Hao Chen、Jianzhong Chen、Ilya D. Gridnev、Wanbin Zhang
DOI:10.1002/anie.202214990
日期:2023.2
The first efficient Ni-catalyzed asymmetric hydrogenation of terminal olefins using H2 was developed, affording chiral ethylphosphine products with up to 99 % yield, 96 % ee and 1000 S/C (substrate/catalyst). The calculation and experimental mechanism study indicate that the two added hydrogen atoms of the product originate from H2 and the reaction proceeds through a NiII rather than Ni0 cyclic process
开发了第一个使用 H 2对末端烯烃进行有效的镍催化不对称氢化反应,提供了高达 99% 收率、96% ee 和 1000 S/C(底物/催化剂)的手性乙基膦产物。计算和实验机理研究表明,产物中加入的两个氢原子来源于H 2,反应通过Ni II而不是Ni 0循环过程进行。