Androst-4-en-3,11-dion-17β-carbonsaeure-methylester | 5062-52-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: Androst-4-en-3,11-dion-17β-carbonsaeure-methylester
• 英文别名: 3,11-dioxo-21-nor-pregnen-(4)-oic acid-(20)-methyl ester；3,11-Dioxo-21-nor-pregnen-(4)-saeure-(20)-methylester；3.11-Dioxo-androsten-(4)-carbonsaeure-(17β)-methylester；17β-Methoxycarbonylandrost-4-ene-3,11-dione；17beta-Methoxycarbonylandrost-4-ene-3,11-dione；methyl (8S,9S,10R,13S,14S,17S)-10,13-dimethyl-3,11-dioxo-2,6,7,8,9,12,14,15,16,17-decahydro-1H-cyclopenta[a]phenanthrene-17-carboxylate
• CAS: 5062-52-2
• 化学式: C₂₁H₂₈O₄
• 分子量: 344.451
• InChiKey: MDSBXIVOBOVZCB-OCMMWJAGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  25
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.76
• 拓扑面积：
  60.4
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  Androst-4-en-3,11-dion-17β-carbonsaeure-methylester 在 sodium borohydrid 作用下， 以 甲醇 为溶剂， 生成 3β-hydroxy-17β-methoxycarbonylandrost-4-en-11-one
  参考文献：
  名称：

  Chemical compounds

  摘要：

  雄烯烷系列类固醇具有3.alpha.-羟基、3.beta.-氢或甲基基团；10-氢原子或甲基基团，11-位置处的11-酮基团或两个氢原子，17.alpha.-氢原子，以及17.beta.-位置上的羧酰化羧基团，N-单或双取代的氨基甲酰基团，氰基团，甲酰基团或乙缩甲酰基团；以及其3.alpha.-酯。这些类固醇具有麻醉性能。

  公开号：

  US03943124A1
• 作为产物：
  描述：

  肾上腺酮 在 chromium(VI) oxide 、 溶剂黄146 作用下， 生成 Androst-4-en-3,11-dion-17β-carbonsaeure-methylester
  参考文献：
  名称：

  ÜberBestandteile der Nebennieren-Rinde（X）。Zur Kenntnis des Cortico-sterons

  摘要：

  DOI：

  10.1002/hlca.193702001138

文献信息

• Behavioural observations of interactions in a free-ranging lynxLynx lynx family at kills
  作者：Paolo Molinari、Anja Molinari-Jobin

  DOI：10.1007/bf03192451

  日期：2001.12

  The behaviour of a free-ranging female lynx Lynx lynx Linnaeus, 1758 and her kittens at 12 different kills was studied for 44 hours of observation from September 1996 to March 1997. The development of interactions at kills of a lynx family group showed the following pattern: until the end of September we often observed two lynx, usually both kittens, food from the kill at the same time. After the age of four months aggression between kittens was observed frequently, with the bigger kitten being dominant. From September the kittens were never again seen feeding together at the kill, However, we never observed fighting, and aggressive behaviour did not increase with the age of the, kittens. Whereas until December one of the kittens was always first at the kill, from January onwards it was mostly the adult female who ate first. She introduced her kittens to the home range of a neighbouring female where the family break-up occurred. The kittens were last seen together with their mother on 26 March. Dispersal seemed to be initiated by the female abandoning the kittens.
• 117. Observations on steroidal 20-keto-21-aldehydes
  作者：E. Caspi、H. Zajac

  DOI：10.1039/jr9640000586

  日期：——
• DE2162595
  申请人：——

  公开号：——

  公开（公告）日：——
• �ber Gallens�uren und verwandte Stoffe. 37. Mitteilung. Herstellung von ?11-unges�ttigten Steroiden mit Hilfe von Sulfoestern
  作者：J. von Euw、T. Reichstein

  DOI：10.1002/hlca.19460290316

  日期：——
• Über Gallensäuren und Verwandte Stoffe. 26. Mitteilung. Derivate der Ätio-cholansäure mit Sauerstoff in 3- und 11-Stellung
  作者：A. Lardon、T. Reichstein

  DOI：10.1002/hlca.19430260302

  日期：1943.5.3