地美索酯盐酸盐 | 518-63-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻嗪类
• 中文名称: 地美索酯盐酸盐
• 中文别名: 2-(2-二甲基氨基乙氧基)乙基吩噻嗪-10-甲酸酯盐酸盐；盐酸地美索酯
• 英文名称: dimethoxanate hydrochloride
• 英文别名: phenothiazine-10-carboxylic acid-[2-(2-dimethylamino-ethoxy)-ethyl ester]; hydrochloride；Phenothiazin-10-carbonsaeure-[2-(2-dimethylamino-aethoxy)-aethylester]; Hydrochlorid；10H-phenothiazine-10-carboxylic acid, 2-[2-(dimethylamino)ethoxy]ethyl ester, monohydrochloride；2-[2-(dimethylamino)ethoxy]ethyl phenothiazine-10-carboxylate;hydron;chloride
• CAS: 518-63-8
• 化学式: C₁₉H₂₂N₂O₃S*ClH
• 分子量: 394.922
• InChiKey: ZJRHNNNACBPWEB-UHFFFAOYSA-N

物化性质

• 熔点：
  161-163 °C (decomp)

计算性质

• 辛醇/水分配系数(LogP)：
  4.43
• 重原子数：
  26
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  67.3
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  N,N-二甲基氨乙基乙二醇 、 吩噻嗪-10-碳酰氯 生成 地美索酯盐酸盐
  参考文献：
  名称：

  Basic alkoxyalkyl esters of phenothiazine-10-carboxylic acid

  摘要：

  公开号：

  US02778824A1

文献信息

• Compositions and methods for the treatment of pain
  申请人：GM Pharmaceuticals, Inc.

  公开号：US10987365B2

  公开（公告）日：2021-04-27

  The claimed invention relates to compositions that may be in a form of a liquid, solid, gel, cream or gel capsule comprising an analgesic, and methods for administering these compositions for treatment of patients suffering from various forms of pain.

  本发明涉及可为液体、固体、凝胶、乳膏或凝胶胶囊形式的包含镇痛剂的组合物，以及使用这些组合物治疗各种形式疼痛患者的方法。
• PROCESS FOR LESSENING POLYMORPHIC CONVERSION OF A DRUG
  申请人：Alza Corporation

  公开号：EP1216058A2

  公开（公告）日：2002-06-26
• PHARMACEUTICAL COMPOSITIONS INCLUDING AN ANTIHISTAMINE AND A STIMULANT AND USE THEREOF
  申请人：Pediamed Pharmaceuticals, Inc.

  公开号：EP1641446A1

  公开（公告）日：2006-04-05
• Pharmaceutical compositions including an antihistamine and a stimulant and method of use thereof
  申请人：PediaMed Pharmaceuticals, Inc.

  公开号：US20040259809A1

  公开（公告）日：2004-12-23

  The present invention provides pharmaceutical compositions including a sedating antihistamine and a stimulant, and methods of use thereof. The stimulant reduces the sedation caused by the antihistamine, thereby allowing potent, but sedating, antihistamines to be used effectively.
• PERSONALIZED PHARMACEUTICAL KITS, PACKAGING AND COMPOSITIONS FOR THE TREATMENT OF ALLERGIC CONDITIONS
  申请人：Du Jie

  公开号：US20090325999A1

  公开（公告）日：2009-12-31

  This invention relates to personalized pharmaceutical kits, packaging, compositions, and methods for treatment of a mammal, comprising at least one antihistamine for treating an allergic disease or condition in a mammal, in combination with at least one wakefulness promoting agent for preventing sedative effects during day time use, while promoting the antihistamine and sedating effect during evening use.

表征谱图