crotylamine hydrochloride

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: crotylamine hydrochloride
• 英文别名: but-2-en-1-amine hydrochloride；(E/Z)-but-2-enamine hydrochloride；But-2-enylazanium;chloride；but-2-enylazanium;chloride
• 化学式: C₄H₉N*ClH
• mdl: MFCD21604106
• 分子量: 107.583
• InChiKey: HNVAXILPAPSDDS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.49
• 重原子数：
  6
• 可旋转键数：
  1
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  26
• 氢给体数：
  2
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  crotylamine hydrochloride 、 氯甲酸三氯甲酯 在 甲烷 作用下， 以 乙酸乙酯 为溶剂， 生成 1-isocyanato-2-butene
  参考文献：
  名称：

  N-Alkenyl and cycloalkyl carbamates as dual acting histamine H3 and H4 receptor ligands

  摘要：

  Previous studies have shown that several imidazole derivatives posses affinity to histamine H-3 and H-4 receptors. Continuing our study on structural requirements responsible for affinity and selectivity for H-3/H-4 receptor subtypes, two series of 3-(1H-imidazol-4-yl) propyl carbamates were prepared: a series of unsaturated alkyl derivatives (1-9) and a series possessing a cycloalkyl group different distances to the carbamate moiety (10-13). The compounds were tested for their affinities at the human histamine H3 receptor, stably expressed in CHO-K1 cells. Compounds 1, 2, 5-7, 10-13 were investigated for their affinities at the human histamine H-4 receptor co-expressed with G alpha(i2) and G beta(1)gamma(2) subunits in Sf9 cells. To expand the pharmacological profile, compounds were further tested for their H3 receptor antagonist activity on guinea pig ileum and in vivo after oral administration to mice. All tested compounds exhibited good affinity for the human histamine H-3 receptor with K-i values in the range from 14 to 194 nM. All compounds were active in vivo after peroral administration (p.o.) to Swiss mice, thus demonstrating their ability to cross the blood-brain barrier. The most potent H-3 receptor ligand of these series was compound 5, 3-(1H-imidazol-4-yl) propyl pent-4-enylcarbamate with the highest affinity (K-i = 14 nM). Additionally, compound 3 showed remarkable central nervous system (CNS) H3R activity, increasing the N-tau-methylhistamine levels in mice with an ED50 value of 0.55 mg/kg, p.o. evidencing therefore, a twofold increase of inverse agonist/antagonist potency compared to the reference inverse agonist/antagonist thioperamide. In this study, the imidazole propyloxy carbamate moiety was kept constant. The different lipophilic moieties connected to the carbamate functionality in the eastern part of the molecule had a range of influences on the human H-4 receptor affinity (154-1326 nM). (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2011.03.046
• 作为产物：
  描述：

  1-phthalimidyl-2-butene 在 一水合肼 、 盐酸 作用下， 以 乙醇 、 水 为溶剂， 反应 3.0h， 以98%的产率得到crotylamine hydrochloride
  参考文献：
  名称：

  N-Alkenyl and cycloalkyl carbamates as dual acting histamine H3 and H4 receptor ligands

  摘要：

  Previous studies have shown that several imidazole derivatives posses affinity to histamine H-3 and H-4 receptors. Continuing our study on structural requirements responsible for affinity and selectivity for H-3/H-4 receptor subtypes, two series of 3-(1H-imidazol-4-yl) propyl carbamates were prepared: a series of unsaturated alkyl derivatives (1-9) and a series possessing a cycloalkyl group different distances to the carbamate moiety (10-13). The compounds were tested for their affinities at the human histamine H3 receptor, stably expressed in CHO-K1 cells. Compounds 1, 2, 5-7, 10-13 were investigated for their affinities at the human histamine H-4 receptor co-expressed with G alpha(i2) and G beta(1)gamma(2) subunits in Sf9 cells. To expand the pharmacological profile, compounds were further tested for their H3 receptor antagonist activity on guinea pig ileum and in vivo after oral administration to mice. All tested compounds exhibited good affinity for the human histamine H-3 receptor with K-i values in the range from 14 to 194 nM. All compounds were active in vivo after peroral administration (p.o.) to Swiss mice, thus demonstrating their ability to cross the blood-brain barrier. The most potent H-3 receptor ligand of these series was compound 5, 3-(1H-imidazol-4-yl) propyl pent-4-enylcarbamate with the highest affinity (K-i = 14 nM). Additionally, compound 3 showed remarkable central nervous system (CNS) H3R activity, increasing the N-tau-methylhistamine levels in mice with an ED50 value of 0.55 mg/kg, p.o. evidencing therefore, a twofold increase of inverse agonist/antagonist potency compared to the reference inverse agonist/antagonist thioperamide. In this study, the imidazole propyloxy carbamate moiety was kept constant. The different lipophilic moieties connected to the carbamate functionality in the eastern part of the molecule had a range of influences on the human H-4 receptor affinity (154-1326 nM). (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2011.03.046

文献信息

• A mild and efficient method for the reduction of nitriles
  作者：Stéphane Laval、Wissam Dayoub、Alain Favre-Reguillon、Mikaël Berthod、Patrice Demonchaux、Gérard Mignani、Marc Lemaire

  DOI：10.1016/j.tetlet.2009.09.164

  日期：2009.12

  A simple and useful method for the reduction of nitriles into the corresponding amines using a tetramethyldisiloxane/titanium(IV) isopropoxide reducing system is described. The synthetic approach is straightforward and provides primary amines as hydrochloride salt in almost quantitative yield. Other advantages of this method, such as easy-to-handle hydride source, inert by-products, that is, TiO2 and

  描述了一种使用四甲基二硅氧烷/异丙醇钛（IV）还原体系将腈还原为相应胺的简单而有用的方法。合成方法很简单，几乎可以定量获得伯胺盐酸盐盐。该方法的其他优点，例如易于处理的氢化物源，惰性副产物（即TiO 2和低聚硅氧烷），使得制备伯胺非常有吸引力。
• Synthesis of Cyclic <i>N</i> ‐Hydroxylated Ureas and Oxazolidinone Oximes Enabled by Chemoselective Iodine(III)‐Mediated Radical or Cationic Cyclizations of Unsaturated <i>N</i> ‐Alkoxyureas
  作者：Laure Peilleron、Pascal Retailleau、Kevin Cariou

  DOI：10.1002/adsc.201901135

  日期：2019.11.19

  In this study we describe the reactivity of unsaturated N‐alkoxyureas in the presence of different combinations of a hypervalent iodine(III) reagent and a bromide source or TEMPO. Three complementary cyclizations can be achieved depending on the reaction conditions. On the one hand, PIFA with pyridinium bromide leads to an oxybromination reaction. On the other hand, bis(tert‐butylcarbonyloxy)iodobenzene

  在这项研究中，我们描述了在高价碘（III）试剂和溴化​​物源或TEMPO不同组合存在下不饱和N-烷氧基脲的反应性。取决于反应条件，可以实现三个互补的环化。一方面，PIFA与溴化吡啶鎓导致氧溴化反应。另一方面，双（叔丁基羰氧基）碘苯与四丁基溴化铵或TEMPO分别触发氨基溴化或氨基氧基胺化反应。对照实验表明，这三个反应是通过不同的机理进行的：第一个过程是离子过程，另外两个过程遵循自由基流形。
• A New Route to 7-Substituted Derivatives of <i>N</i>-{4-[2-(2-Amino-3,4-dihydro-4-oxo-7<i>H</i>-pyrrolo[2,3-<i>d</i>]pyrimidin-5-yl)- ethyl]benzoyl}-<scp>l</scp>-glutamic Acid [ALIMTA (LY231514, MTA)]¹
  作者：Edward C. Taylor、Bin Liu

  DOI：10.1021/jo001580l

  日期：2001.6.1

  unexpected redox reaction to the diethyl esters 9 of a series of 7-substituted derivatives of ALIMTA (LY231514, MTA), from which the target analogues 10 were readily prepared by saponification. Attempted deprotection at position 7 was successful in only one case (9d, R = CH(2)C(6)H(3)(OMe)(2)(-3',4'), which resulted in a known pentultimate precursor (9, R = H) of ALIMTA. The 7-substituted derivatives 10 proved

  用巴豆基溴将各种伯胺烷基化，然后用DMAP促进用甲基丙二酰氯酰化为4，然后由三乙酸锰二水合物/乙酸铜诱导的自由基环化，得到1-取代的4-乙烯基-3-羰基甲氧基-2-吡咯烷酮（ 5）。然后对硫代内酰胺6进行硫杂化和胍环化，得到一系列的2-氨基-3,4-二氢-4-氧代-5-乙烯基-7-取代的吡咯并[2,3-d]嘧啶（7）。钯催化的CC与4-碘苯甲酰谷氨酸二乙酯的偶联反应通过意外的氧化还原反应一步一步地与ALIMTA的一系列7-取代衍生物的二乙基酯9（LY231514，MTA）结合，从中可以轻松地制备目标类似物10皂化。仅在一种情况下（9d，R = CH（2）C（6）H（3）（OMe）（2）（-3'，4'），尝试在7位脱保护成功，得到已知的ALIMTA的五倍前体（9，R = H）。7-取代的衍生物10被证明在体外作为细胞分裂的抑制剂是无活性的。
• N-Alkenyl and cycloalkyl carbamates as dual acting histamine H3 and H4 receptor ligands
  作者：Małgorzata Więcek、Tim Kottke、Xavier Ligneau、Walter Schunack、Roland Seifert、Holger Stark、Jadwiga Handzlik、Katarzyna Kieć-Kononowicz

  DOI：10.1016/j.bmc.2011.03.046

  日期：2011.5

  Previous studies have shown that several imidazole derivatives posses affinity to histamine H-3 and H-4 receptors. Continuing our study on structural requirements responsible for affinity and selectivity for H-3/H-4 receptor subtypes, two series of 3-(1H-imidazol-4-yl) propyl carbamates were prepared: a series of unsaturated alkyl derivatives (1-9) and a series possessing a cycloalkyl group different distances to the carbamate moiety (10-13). The compounds were tested for their affinities at the human histamine H3 receptor, stably expressed in CHO-K1 cells. Compounds 1, 2, 5-7, 10-13 were investigated for their affinities at the human histamine H-4 receptor co-expressed with G alpha(i2) and G beta(1)gamma(2) subunits in Sf9 cells. To expand the pharmacological profile, compounds were further tested for their H3 receptor antagonist activity on guinea pig ileum and in vivo after oral administration to mice. All tested compounds exhibited good affinity for the human histamine H-3 receptor with K-i values in the range from 14 to 194 nM. All compounds were active in vivo after peroral administration (p.o.) to Swiss mice, thus demonstrating their ability to cross the blood-brain barrier. The most potent H-3 receptor ligand of these series was compound 5, 3-(1H-imidazol-4-yl) propyl pent-4-enylcarbamate with the highest affinity (K-i = 14 nM). Additionally, compound 3 showed remarkable central nervous system (CNS) H3R activity, increasing the N-tau-methylhistamine levels in mice with an ED50 value of 0.55 mg/kg, p.o. evidencing therefore, a twofold increase of inverse agonist/antagonist potency compared to the reference inverse agonist/antagonist thioperamide. In this study, the imidazole propyloxy carbamate moiety was kept constant. The different lipophilic moieties connected to the carbamate functionality in the eastern part of the molecule had a range of influences on the human H-4 receptor affinity (154-1326 nM). (C) 2011 Elsevier Ltd. All rights reserved.