dansyl iodide | 622837-75-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: dansyl iodide
• 英文别名: 5-(Dimethylamino)naphthalene-1-sulfonyl iodide；5-(dimethylamino)naphthalene-1-sulfonyl iodide
• CAS: 622837-75-6
• 化学式: C₁₂H₁₂INO₂S
• 分子量: 361.203
• InChiKey: MXEVRAZBSSAFGG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  45.8
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  乙二醇二甲基丙烯酸酯 、 dansyl iodide 在 三乙胺 作用下， 以 四氯化碳 为溶剂， 反应 48.0h， 以32%的产率得到ethylele glycol 1-methacrylate 2-[2-(dansylmethyl)acrylate]
  参考文献：
  名称：

  Novel Trifunctional Building Blocks for Fluorescent Polymers

  摘要：

  [GRAPHICS]Herein, we describe the synthesis of fluorescent 2-(arylsulfonyl)methacrylates and its polymers. These novel trifunctional monomers, possessing a fluorescent arylsulfonyl (ArSO2) group, an alkyl group (R), and a polymerizable olefin, serve as useful building blocks for functionalized fluorescent polymers.

  DOI：

  10.1021/ol035500m
• 作为产物：
  描述：

  丹酰氯 在 碘 、 碳酸氢钠 、 sodium sulfite 作用下， 以 乙醇 、 水 为溶剂， 反应 15.0h， 生成 dansyl iodide
  参考文献：
  名称：

  Novel Trifunctional Building Blocks for Fluorescent Polymers

  摘要：

  [GRAPHICS]Herein, we describe the synthesis of fluorescent 2-(arylsulfonyl)methacrylates and its polymers. These novel trifunctional monomers, possessing a fluorescent arylsulfonyl (ArSO2) group, an alkyl group (R), and a polymerizable olefin, serve as useful building blocks for functionalized fluorescent polymers.

  DOI：

  10.1021/ol035500m

文献信息

• METHOD FOR PREPARING SITE-SPECIFICALLY MODIFIED PROTEIN BASED ON NOVEL CARBON-CARBON BOND FORMATION
  申请人：Korea Advanced Institute of Science and Technology

  公开号：US20180066011A1

  公开（公告）日：2018-03-08

  A method for producing a site-specifically modified protein based on new carbon-carbon bond formation is disclosed, including the following three steps (marking, activation, and coupling steps): (a) marking of the modification site by incorporating a specific amino acid into a selected position of a target protein; (b) activation of the marked site; and (c) coupling of various post-translational modification (PTM) moieties or other chemical groups onto the activated site to obtain a site-specifically modified protein. The method for producing a site-specifically modified protein can incorporate desired diverse chemical groups including post-translational modification (PTM) moieties into a designated site in a target protein through a new carbon-carbon bond. Furthermore, the modified protein having a site-specific PTM exhibits the same chemical and functional properties as that of a target protein present in cells. Thus, the present invention is useful for studies of cellular proteins, human diseases including cancers and neurodegenerative diseases, and new drug discovery.

  揭示了一种基于新的碳-碳键形成的方法，用于产生具有特定位点修饰的蛋白质，包括以下三个步骤（标记、激活和偶联步骤）：(a) 通过将特定氨基酸纳入目标蛋白质的选定位置来标记修饰位点；(b) 激活标记的位点；以及(c) 将各种翻译后修饰（PTM）基团或其他化学基团偶联到激活位点，从而获得具有特定位点修饰的蛋白质。用于产生具有特定位点修饰的蛋白质的方法可以通过新的碳-碳键将所需的多样化化学基团，包括翻译后修饰（PTM）基团，纳入目标蛋白质的指定位点。此外，具有特定位点PTM的修饰蛋白质表现出与细胞中存在的目标蛋白质相同的化学和功能特性。因此，本发明对于细胞蛋白质、包括癌症和神经退行性疾病在内的人类疾病的研究以及新药物发现是有用的。
• [EN] IMMOLATIVE CELL-PENETRATING COMPLEXES FOR NUCLEIC ACID DELIVERY<br/>[FR] COMPLEXES DE PÉNÉTRATION CELLULAIRE IMMOLATEURS POUR L'ADMINISTRATION D'ACIDES NUCLÉIQUES
  申请人：UNIV LELAND STANFORD JUNIOR

  公开号：WO2018022930A1

  公开（公告）日：2018-02-01

  There are provided herein, inter alia, complexes, compositions and methods for the delivery of therapeutic, diagnostic and imaging agents, including nucleic acid, into a cell. The complexes, compositions and methods may facilitate complexation, protection, delivery and release of oligonucleotides and polyanionic cargos into target cells, tissues, and organs both in vitro and in vivo.

  本文提供了用于将治疗性、诊断性和成像剂（包括核酸）输送到细胞内的复合物、组合物和方法。这些复合物、组合物和方法可以促进寡核苷酸和多阴离子载体与靶细胞、组织和器官的复合、保护、传递和释放，无论是在体外还是体内。
• Novel Labelled Cannabinergic Ligands and Related Analogs
  申请人：Makriyannis Alexandros

  公开号：US20210300937A1

  公开（公告）日：2021-09-30

  Novel cannabinoid ligands represented by the general formulas I, II, and III and methods for preparation and use within which one or more of a fluorescent ligand, nitroxide spin label, metal chelate, biotin moiety, or group with enhanced polarity may be incorporated. The compounds can bind to and modulate the cannabinoid CB1 and CB2 receptors and thereby considered specific ligands for these receptors. Some of the disclosed compounds that bind to cannabinoid CB1 and CB2 receptors can exhibit tight or irreversible binding characteristics for these receptors. Due to the presence of the imaging/diagnostic and/or therapeutic functional groups including fluorescent groups, nitroxide spin labels, metal chelates, biotin moieties, and groups with enhanced polarity, the disclosed compounds may be useful as imaging/diagnostic tools and/or therapeutic agents.

  新型大麻素配体由一般公式I、II和III表示，以及用于制备和使用的方法，其中可以包含一个或多个荧光配体、亚硝基自旋标记、金属螯合物、生物素基团或具有增强极性的基团。这些化合物可以结合并调节大麻素CB1和CB2受体，因此被认为是这些受体的特异性配体。一些公开的结合到大麻素CB1和CB2受体的化合物可能表现出对这些受体的紧密或不可逆结合特性。由于含有成像/诊断和/或治疗功能基团，包括荧光基团、亚硝基自旋标记、金属螯合物、生物素基团和具有增强极性的基团，公开的这些化合物可能作为成像/诊断工具和/或治疗剂而有用。
• Method for preparing site-specifically modified protein based on novel carbon-carbon bond formation
  申请人：Korea Advanced Institute of Science and Technology

  公开号：US10723760B2

  公开（公告）日：2020-07-28

  A method for producing a site-specifically modified protein based on new carbon-carbon bond formation is disclosed, including the following three steps (marking, activation, and coupling steps): (a) marking of the modification site by incorporating a specific amino acid into a selected position of a target protein; (b) activation of the marked site; and (c) coupling of various post-translational modification (PTM) moieties or other chemical groups onto the activated site to obtain a site-specifically modified protein. The method for producing a site-specifically modified protein can incorporate desired diverse chemical groups including post-translational modification (PTM) moieties into a designated site in a target protein through a new carbon-carbon bond. Furthermore, the modified protein having a site-specific PTM exhibits the same chemical and functional properties as that of a target protein present in cells. Thus, the present invention is useful for studies of cellular proteins, human diseases including cancers and neurodegenerative diseases, and new drug discovery.

  本发明公开了一种基于新碳-碳键形成的位点特异性修饰蛋白质的生产方法，包括以下三个步骤（标记、活化和耦合步骤）：(a) 通过将特定氨基酸加入目标蛋白质的选定位置来标记修饰位点；(b) 激活标记位点；(c) 将各种翻译后修饰（PTM）分子或其他化学基团偶联到激活位点上，以获得位点特异性修饰蛋白质。生产位点特异性修饰蛋白质的方法可以通过新的碳-碳键将所需的各种化学基团（包括翻译后修饰（PTM）分子）结合到目标蛋白质的指定位点上。此外，具有位点特异性 PTM 的修饰蛋白与细胞中的目标蛋白具有相同的化学和功能特性。因此，本发明可用于研究细胞蛋白质、人类疾病（包括癌症和神经退行性疾病）以及新药研发。
• US9580721B2
  申请人：——

  公开号：US9580721B2

  公开（公告）日：2017-02-28