3-Anilino-1-(4-t-butyl-phenoxy)-propan-2-ol | 42313-66-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-Anilino-1-(4-t-butyl-phenoxy)-propan-2-ol
• 英文别名: 2-Propanol, 1-[4-(1,1-dimethylethyl)phenoxy]-3-(phenylamino)-；1-anilino-3-(4-tert-butylphenoxy)propan-2-ol
• CAS: 42313-66-6
• 化学式: C₁₉H₂₅NO₂
• 分子量: 299.413
• InChiKey: KLSWWJZNCOFFAH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  22
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  41.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  苯胺 、 对叔丁基苯基1-(2,3-环氧)丙基醚 在 sulfated zirconia 作用下， 以 neat (no solvent) 为溶剂， 反应 0.5h， 以98%的产率得到3-Anilino-1-(4-t-butyl-phenoxy)-propan-2-ol
  参考文献：
  名称：

  Solvent-free aminolysis of aliphatic and aryloxy epoxides with sulfated zirconia as solid acid catalyst

  摘要：

  Single-step and two-steps synthetic procedure for the synthesis of sulfated zirconia (SZ) was developed, which were calcined at 500, 600 and 700 degrees C and characterized by various physico-chemical methods such as PXRD, FTIR, surface area, microanalysis, NH3-TPD and DRIFT analysis. These SZ materials were then employed as solid acid catalysts for the aminolysis of different aliphatic/aromatic terminal, aryloxy and meso epoxides with aromatic and aliphatic amines under ambient conditions. Amongst the catalyst prepared, SZ-2-600 prepared in two-steps and 600 degrees C calcined was found to be the most efficient catalyst to give beta-amino alcohols in up to 98% yield and >99% regioselectivity. The SZ catalyst was successfully recycled and reused up to six catalytic runs with intact efficiency. (C) 2014 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.apcata.2014.08.024

文献信息

• Fe(OH)3 nano solid material: An efficient catalyst for regioselective ring opening of aryloxy epoxide with amines under solvent free condition
  作者：Arpan K. Shah、K. Jeya Prathap、Manish Kumar、Sayed H.R. Abdi、Rukhsana I. Kureshy、Noor-ul H. Khan、Hari C. Bajaj

  DOI：10.1016/j.apcata.2013.10.003

  日期：2014.1

  Iron hydroxide-Fe(OH)(3) and iron oxides (Fe3O4 and Fe2O3) were successfully prepared and characterized. These materials were employed as efficient and environmentally benign heterogeneous catalysts for the epoxide ring opening reaction of various alyloxy, terminal and meso epoxides with aromatic and aliphatic amines under solvent free condition at room temperature. Out of these, nano-sized Fe(OH)(3) (IH-1) showed better catalytic activity to give the product beta-amino alcohols in excellent yield (up to similar to 96%) and high regioselectivity in 10-360 min. The catalyst was successfully recycled and reused eight times with no loss in catalytic activity. (C) 2013 Published by Elsevier B.V.