N-甲酸基脲 | 1190-24-5

• 物质功能分类: 化学试剂 - 有机试剂 - 脲
• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机碳酸及其衍生物
• 中文名称: N-甲酸基脲
• 中文别名: 甲酰尿素；N-甲酰基脲
• 英文名称: formylurea
• 英文别名: Formyl-harnstoff；N-formyl urea；N-Formylharnstoff；N-carbamoylformamide
• CAS: 1190-24-5
• 化学式: C₂H₄N₂O₂
• mdl: MFCD00039769
• 分子量: 88.066
• InChiKey: JOWMUPQBELRFRZ-UHFFFAOYSA-N

物化性质

• 熔点：
  170-173 °C
• 沸点：
  162.99°C (rough estimate)
• 密度：
  1.4371 (rough estimate)
• 稳定性/保质期：
  如果按照规格使用和储存，则不会分解，也未有已知危险反应。请避免接触氧化物。

计算性质

• 辛醇/水分配系数(LogP)：
  -0.7
• 重原子数：
  6
• 可旋转键数：
  0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  72.2
• 氢给体数：
  2
• 氢受体数：
  2

安全信息

• 安全说明：
  S24/25
• 危险类别码：
  R36/37/38
• 海关编码：
  2924210090
• 储存条件：
  请将贮藏器密封，并存放在阴凉、干燥处。同时，确保工作环境有良好的通风或排气设施。

SDS

Name:	N-Formylurea 99% Material Safety Data Sheet
Synonym:	None Known
CAS:	1190-24-5

Section 1 - Chemical Product MSDS Name:N-Formylurea 99% Material Safety Data Sheet
Synonym:None Known

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Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS

CAS#	Chemical Name	content	EINECS#
1190-24-5	N-Formylurea, 99%	99	214-719-4

Hazard Symbols: None Listed.
Risk Phrases: None Listed.

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Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
The toxicological properties of this material have not been fully investigated.
Potential Health Effects
Eye:
May cause eye irritation.
Skin:
May cause skin irritation.
Ingestion:
May cause irritation of the digestive tract. The toxicological properties of this substance have not been fully investigated.
Inhalation:
May cause respiratory tract irritation. The toxicological properties of this substance have not been fully investigated.
Chronic:
No information found.

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Section 4 - FIRST AID MEASURES
Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:
Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
Ingestion:
Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
Inhalation:
Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:

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Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Runoff from fire control or dilution water may cause pollution.
Extinguishing Media:
In case of fire, use water, dry chemical, chemical foam, or alcohol-resistant foam. Use agent most appropriate to extinguish fire.

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Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Vacuum or sweep up material and place into a suitable disposal container. Clean up spills immediately, observing precautions in the Protective Equipment section. Avoid generating dusty conditions.
Provide ventilation.

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Section 7 - HANDLING and STORAGE
Handling:
Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Use with adequate ventilation. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation.
Storage:
Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.

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Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate general or local exhaust ventilation to keep airborne concentrations below the permissible exposure limits.
Exposure Limits CAS# 1190-24-5: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to minimize contact with skin.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

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Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Powder
Color: white
Odor: None reported.
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: 170.00 - 173.00 deg C
Autoignition Temperature: Not available.
Flash Point: Not available.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water: soluble
Specific Gravity/Density:
Molecular Formula: C2H4N2O2
Molecular Weight: 88.06

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Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Stable under normal temperatures and pressures.
Conditions to Avoid:
Incompatible materials, dust generation, excess heat, strong oxidants.
Incompatibilities with Other Materials:
Oxidizing agents.
Hazardous Decomposition Products:
Nitrogen oxides, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide.
Hazardous Polymerization: Has not been reported.

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Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 1190-24-5 unlisted.
LD50/LC50:
Not available.
Carcinogenicity:
N-Formylurea, 99% - Not listed by ACGIH, IARC, or NTP.

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Section 12 - ECOLOGICAL INFORMATION

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Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.

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Section 14 - TRANSPORT INFORMATION

IATA
Shipping Name: Not regulated.
Hazard Class:
UN Number:
Packing Group:
IMO
Shipping Name: Not regulated.
Hazard Class:
UN Number:
Packing Group:
RID/ADR
Shipping Name: Not regulated.
Hazard Class:
UN Number:
Packing group:

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Section 15 - REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: Not available.
Risk Phrases:
Safety Phrases:
S 24/25 Avoid contact with skin and eyes.
WGK (Water Danger/Protection)
CAS# 1190-24-5: No information available.
Canada
None of the chemicals in this product are listed on the DSL/NDSL list.
CAS# 1190-24-5 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 1190-24-5 is not listed on the TSCA inventory.
It is for research and development use only.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为反应物：
  描述：

  N-甲酸基脲 在 氢氧化钾 、 mercury dichloride 作用下， 生成 formyl-urea; mercury-compound
  参考文献：
  名称：

  Matignon, Bulletin de la Societe Chimique de France, 1894, vol. <3>11, p. 573

  摘要：

  DOI：
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 ozone-containing oxygen 、 溶剂黄146 作用下， 生成 N-甲酸基脲
  参考文献：
  名称：

  RESEARCHES ON PYRIMIDINES. CXXI. THE ACTION OF OZONE ON SOME DERIVATIVES OF URACIL

  摘要：

  DOI：

  10.1021/ja01354a039

文献信息

• Synthesis and characterization of functionalized dihydropyrimidinones via one-pot isocyanide-based three-component reaction of N-formyl urea and dialkyl ACETYLENEDICARBOXYLATES
  作者：A. Naderi、B. Mohtat

  DOI：10.4314/bcse.v31i2.16

  日期：——

  generated by the addition of alkyl isocyanides to dialkyl acetylenedicarboxylates was trapped by N-formyl urea to produce highly functionalized dihydropyrimidinones in fairly good yields. KEY WORDS : Alkyl isocyanides, Dialkyl acetylenedicarboxylate, N-Formyl urea, Three-component reaction, Dihydropyrimidinones Bull. Chem. Soc. Ethiop. 2017 , 31(2), 345-350. DOI: http://dx.doi.org/10.4314/bcse.v31i2.16

  通过将烷基异氰化物加成乙炔基二羧酸二烷基酯生成的反应性中间体被N-甲酰脲捕获，以相当好的收率生产高度官能化的二氢嘧啶酮。关键词：烷基异氰化物，乙炔二羧酸二烷基酯，N-甲酰脲，三组分反应，二氢嘧啶酮。化学 Soc。埃塞俄比亚。2017，31（2），345-350。DOI：http：//dx.doi.org/10.4314/bcse.v31i2.16
• An Efficient Synthesis of Functionalised Hexahydropyrimidines via the Reaction of <i>N</i>-Formyl Ureas/Thioureas with an Acetylenic Ester in the Presence of an Aryl Phosphine
  作者：Nasim Shams、Mohammad Hossein Mosslemin、Afshin Yazdani、Hossein Anaraki-Ardakani、Javad Ghane

  DOI：10.3184/174751916x14627910569540

  日期：2016.6

  The synthesis of eight functionalised hexahydropyrimidines in good to excellent yields has been achieved via a three-component 1:1:1 reaction of a triarylphosphine, a dialkyl acetylenedicarboxylate and a N-formylurea or N-formylthiourea at room temperature.

  通过三芳基膦、乙炔二羧酸二烷基酯和 N-甲酰脲或 N-甲酰硫脲的三组分 1:1:1 反应，在室温下合成了八种功能化的六氢嘧啶，收率良好到极好。
• US2826580
  申请人：——

  公开号：——

  公开（公告）日：——
• THE SYNTHESIS OF ETHYL-(1-METHYLBUTYL)- AND ETHYLISOAMYL-MALONURIC ACIDS¹
  作者：E. W. MAYNERT、ELIZABETH WASHBURN

  DOI：10.1021/jo01148a008

  日期：1950.3
• v.Gorski, Chemische Berichte, 1896, vol. 29, p. 2048
  作者：v.Gorski

  DOI：——

  日期：——

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