N,N-二异丙基羟胺 | 5765-61-7

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: N,N-二异丙基羟胺
• 英文名称: N,N-diisopropylhydroxylamine
• 英文别名: di-isopropyl-hydroxylamine；N-hydroxydiisopropylamine；N,N-di(propan-2-yl)hydroxylamine
• CAS: 5765-61-7
• 化学式: C₆H₁₅NO
• 分子量: 117.191
• InChiKey: OQAIUHLITJGRMM-UHFFFAOYSA-N

物化性质

• 沸点：
  152.4±9.0 °C(Predicted)
• 密度：
  0.880±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  8
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  23.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N,N-二异丙基羟胺 在 盐酸 、 tin 作用下， 生成 二异丙胺
  参考文献：
  名称：

  Bewad, Zhurnal Russkago Fiziko-Khimicheskago Obshchestva, 1907, vol. 39, p. 953

  摘要：

  DOI：
• 作为产物：
  描述：

  二异丙氨基乙基氯盐酸盐 在 Adogen-464 、 potassium tert-butylate 、 3-(4-nitrophenyl)-2-(phenylsulfonyl)-1,2-oxaziridine 作用下， 以 氘代氯仿 为溶剂， 反应 15.0h， 生成 N,N-二异丙基羟胺
  参考文献：
  名称：

  .beta.-(N,N-Dialkylamino)ethyl arylthiosulfonates: new simulants for O-ethyl S-[2-(diisopropylamino)ethyl] methylphosphonothioate

  摘要：

  Beta-(N,N-Dialkylamino)ethyl arylthiosulfonates 2, new simulants for the hydrolysis and oxidation chemistry of VX (1), are prepared in good yield by reaction of a potassium arylthiosulfonate with a 2-chloroethylamine. Alkaline hydrolysis of 2 results in cleavage of the S-S bond to give sulfinic acids and disulfides. Like VX, oxidation of 2 by N-sulfonyloxaziridine 12 occurs exclusively on nitrogen to give the corresponding amine oxide which subsequently undergoes a Cope elimination reaction affording the vinyl sulfide 14.

  DOI：

  10.1021/jo00035a013

文献信息

• Oxidative detoxification of phosphonothiolates
  作者：Yu Chu Yang、Linda L. Szafraniec、William T. Beaudry、Dennis K. Rohrbaugh

  DOI：10.1021/ja00174a025

  日期：1990.8

  The chemical nerve agent O-ethyl S-[2-(diisopropylamino) ethyl] methylphosphonothiolate (VX) is an unusually selective oxidation substrate. Relative to the thiolo sulfur, the amino nitrogen was a more reactive oxidation site. The oxidation of VX and a phosphonothiolate derivative by a broad range of peroxygen compounds was examined in organic, polar organic, and aqueous solvents

  化学神经毒剂 O-乙基 S-[2-(二异丙基氨基) 乙基] 甲基硫代膦酸酯 (VX) 是一种不寻常的选择性氧化底物。相对于硫醇硫，氨基氮是更具反应性的氧化位点。在有机、极性有机和水性溶剂中，研究了多种过氧化合物对 VX 和硫代膦酸酯衍生物的氧化
• Methyltrioxorhenium-catalysed oxidation of secondary amines to nitrones in ionic liquids
  作者：Mária Mečiarová、Melinda Mojzesová、Radovan Šebesta

  DOI：10.2478/s11696-012-0208-5

  日期：2013.1.1

  Nitrones serve as starting materials for the synthesis of many heterocycles. Oxidation of secondary amines using hydrogen peroxide and the catalytic amount of methyltrioxorhenium in ionic liquids is a useful method for the preparation of nitrones. Ultrasonic irradiation and ionic liquids have a positive influence on the reaction. The nitrones required were isolated in good yields. Corresponding hydroxylamines

  氮用作合成许多杂环的起始原料。使用过氧化氢氧化仲胺和在离子液体中催化量的甲基三氧or鎓是制备硝酮的有用方法。超声波辐射和离子液体对反应有积极影响。所需的硝酮以高收率分离。相应的羟胺很容易被氧化成硝酮，通常伴随着主要产物。离子液体中的甲基三氧or可在多个反应循环中重复使用，而对反应过程没有任何恶化的影响。
• [EN] NO-RELEASING NITROOXY-CHROMENE CONJUGATES<br/>[FR] CONJUGUÉS NITROOXY-CHROMÈNE À LIBÉRATION DE NO
  申请人：EUCLISES PHARMACEUTICALS INC

  公开号：WO2015109011A1

  公开（公告）日：2015-07-23

  The present invention provides NO-releasing nitrooxy-alkylenyl-linked-chromene conjugates, having the structure of Formula (1 ) wherein R1, R2, R3, R4, X, and L are as defined in the detailed description; pharmaceutical compositions comprising at least one compound o Formula (I); and methods useful for healing wounds, preventing and treating cancer and treating actinic keratosis, cystic fibrosis, and acne, using a compound of Formula (1).

  本发明提供了NO释放的硝基氧烷基连接的香豆素共轭物，其具有如下式（1）的结构，其中R1、R2、R3、R4、X和L如详细描述中所定义；包含至少一种Formula（I）化合物的药物组合物；以及使用Formula（1）化合物有益于愈合伤口、预防和治疗癌症以及治疗日光性角化症、囊性纤维化和痤疮的方法。
• Different modes of aggregation in organoaluminium and -gallium hydroxylamides
  作者：Norbert W. Mitzel、Christian Lustig、Markus Woski

  DOI：10.1039/b311781b

  日期：——

  The organoaluminium and -gallium hydroxylamides (Me2GaONMe2)2, (tBu2AlONMe2)2, (tBu2GaONMe2)2 and (Me2AlONiPr2)2 have been prepared by the reaction of the hydroxylamines Me2NOH and iPr2NOH with the trialkylmetal compounds trimethylgallium, tri-tbutylaluminium and tri-tbutylgallium, respectively. All compounds have been characterised by NMR spectroscopy (1H, 13C, 15N, 17O and 27Al), by mass spectrometry and elemental analyses. The crystal structures of the four compounds have been determined, showing that they all form dimers but with different modes of aggregation: (Me2GaONMe2)2 has a Ga2O2N2 six-membered ring, (tBu2AlONMe2)2 and (Me2AlONiPr2)2 have Al2O2 four-membered rings, (tBu2GaONMe2)2 forms a Ga2O2N five-membered ring.

  通过羟胺Me2NOH和iPr2NOH分别与三甲基镓、三叔丁基铝和三叔丁基镓反应，制备了有机铝和镓的羟胺盐(Me2GaONMe2)2、(tBu2AlONMe2)2、(tBu2GaONMe2)2和(Me2AlONiPr2)2。所有化合物均通过NMR光谱（1H、13C、15N、17O和27Al）、质谱和元素分析进行了表征。四个化合物的晶体结构已经确定，显示它们都以二聚体形式存在，但聚集模式不同：(Me2GaONMe2)2具有六元环Ga2O2N2，(tBu2AlONMe2)2和(Me2AlONiPr2)2具有四元环Al2O2，而(tBu2GaONMe2)2则形成五元环Ga2O2N。
• [EN] NO-RELEASING NONOATE(OXYGEN-BOUND)CHROMENE CONJUGATES<br/>[FR] CONJUGUÉS DE NONOATE(LIÉ À L'OXYGÈNE)CHROMÈNE LIBÉRANT DE L'OXYDE NITRIQUE
  申请人：EUCLISES PHARMACEUTICALS INC

  公开号：WO2015109014A1

  公开（公告）日：2015-07-23

  The present invention provides NO-releasing NONOate(oxygen bound)chromene conjugates, having the structure of Formula (I): wherein Z, R1, R2, R3, R4, R5, R6, and R7 are as defined in the detailed description; pharmaceutical compositions comprising at least one compound of Formula (I); and methods useful for healing wounds, preventing and treating cancer, or treating actinic keratosis, cystic fibrosis, or acne, using a compound of Formula (I).

  本发明提供了释放NO的NONOate（氧结合）香豆素共轭物，其具有如下结构（I）的结构：其中Z、R1、R2、R3、R4、R5、R6和R7如详细描述中所定义；包括至少一种化合物的制药组合物（I）；以及使用化合物（I）有益于愈合伤口、预防和治疗癌症，或治疗光老化性角化症、囊性纤维化或痤疮的方法。