N-甲基-N-(2-羟乙基)-1,3-丙二胺 | 41999-70-6

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: N-甲基-N-(2-羟乙基)-1,3-丙二胺
• 中文别名: N-(2-羟乙基)-N-甲基-1,3-丙二胺；2-[(3-氨基丙基)甲基氨基]乙醇；N-甲基-N-羟乙基-1,3-丙撑二胺；N-甲基-N-羟乙基-1,3-丙二胺；APMMEA
• 英文名称: N-(2-hydroxyethyl)-N-methyl-1,3-propanediamine
• 英文别名: 2-[(3-Aminopropyl)methylamino]ethanol；2-[3-aminopropyl(methyl)amino]ethanol
• CAS: 41999-70-6
• 化学式: C₆H₁₆N₂O
• 分子量: 132.206
• InChiKey: UOQYWMZLTNEIFI-UHFFFAOYSA-N

物化性质

• 沸点：
  229℃
• 密度：
  0.971
• 闪点：
  92℃
• LogP：
  -1.23 at 21℃

计算性质

• 辛醇/水分配系数(LogP)：
  -1
• 重原子数：
  9
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  49.5
• 氢给体数：
  2
• 氢受体数：
  3

安全信息

• 海关编码：
  2922199090

反应信息

• 作为反应物：
  描述：

  N-甲基-N-(2-羟乙基)-1,3-丙二胺 在 氯化亚砜 作用下， 反应 1.5h， 生成 1, N-(2-chloroethyl)-N'-(2-methoxy-9-acridinyl)-N-methyl-, dihydrochloride
  参考文献：
  名称：

  Synthesis and DNA-sequence selectivity of a series of mono- and difunctional 9-aminoacridine nitrogen mustards

  摘要：

  The aim of this work was to identify nitrogen mustards that would react selectively with DNA, particularly in G-rich regions. A sei ies of mono- and difunctional nitrogen mustards was synthesized in which the (2-chloroethyl)amino functions were connected to the N-9 of 9-aminoacridine by way of a spacer chain consisting of two to six methylene units. The length of the spacer chain connecting the alkylating and putative DNA-intercalating groups was found to affect the preference for the alkylation of different guanine-N-7 positions in a DNA sequence. All of the compounds reacted preferentially at G's that are followed by G as do most other types of nitrogen mustards, but the degree of selectivity was greater. The compounds reacted at much lower concentrations than were required for comparable reaction by mechlorethamine (HN2), consistent with initial noncovalent binding to DNA prior to guanine-N-7 alkylation. The degree of DNA-sequence selectivity increased as the spacer-chain length decreased below four methylene units. Most strikingly, long spacer compounds reacted strongly at 5'-GT-3' sequences, Whereas this reaction was almost completely suppressed when-the spacer length was reduced to two or three methylenes. Mono- and difunctional compounds of a given spacer length showed no consistent difference in DNA-sequence preference.

  DOI：

  10.1021/jm00027a008
• 作为产物：
  描述：

  3-[(2-羟基乙基)氨基]丙腈 在 甲酸 、 乙醇 、 氨 、 镍 作用下， 120.0 ℃ 、8.83 MPa 条件下， 生成 N-甲基-N-(2-羟乙基)-1,3-丙二胺
  参考文献：
  名称：

  Ishiguro; Matsumura, Yakugaku Zasshi/Journal of the Pharmaceutical Society of Japan, 1959, vol. 79, p. 153,156

  摘要：

  DOI：

文献信息

• Softener composition
  申请人：Ushio Noriaki

  公开号：US20050090423A1

  公开（公告）日：2005-04-28

  A softener composition that can impart a high softening effect to clothes irrespective of the state of rinsing water, which contains (a) a compound of formula (1) below, (b) a compound of formula (3) below, and (c) a specific anionic surfactant, wherein the mole ratios between the components (a), (b) and (c) satisfy the following relationship: [(a)+(b)]/(c)=9/1 to 4/6; and wherein R 1 represents a C 13-36 alkyl group or the like, R 10 and R 12 respectively represent a C 8-36 alkyl group or the like, R 2 , R 11 and R 13 respectively represent a C 1-6 alkylene group, R 3 , R 4 , and R 14 respectively represent a C 1-3 alkyl group or the like, A, D and E respectively represent —COO—, —CONH— or the like, and “a”, “c” and “d” respectively denote 0 or 1.

  一种软化剂组合物，可以在漂洗水的状态不同的情况下赋予衣物高度的柔软效果，该组合物包含以下的化合物：(a) 下式的化合物，(b) 下式的化合物，以及(c) 特定的阴离子表面活性剂，其中组分(a)、(b)和(c)之间的摩尔比满足以下关系：[(a)+(b)]/(c)=9/1至4/6；其中R1代表C13-36烷基基团或类似物，R10和R12分别代表C8-36烷基基团或类似物，R2、R11和R13分别代表C1-6烷基烯基基团，R3、R4和R14分别代表C1-3烷基基团或类似物，A、D和E分别代表—COO—、—CONH—或类似物，“a”、“c”和“d”分别表示0或1。
• N,N,N’-三甲基-N’-氨丙基双胺基乙基醚
  申请人：史小鸣

  公开号：CN105884629A

  公开（公告）日：2016-08-24

  本技术提供了二种工艺生产新型聚氨酯催化剂N，N，N’-三甲基-N’-氨丙基双胺基乙基醚的合成方法。方法一：是以三甲基双胺基乙基醚为原料，与丙烯晴反应，产物再在催化剂骨架镍、钯炭、铂炭、钌炭等条件下加氢，经分离后即可得目的产品。方法二：是以二甲基乙醇胺与N-甲基-N-氨丙基乙醇胺缩合，经分离获得。
• (3-oxo)pyridazin-4-ylurea derivatives as PDE4 inhibitors
  申请人：Almirall, S.A.

  公开号：EP2196465A1

  公开（公告）日：2010-06-16

  New (3-oxo)pyridazin-4-ylurea derivatives having the chemcial structure of formula (I) are disclosed; as well as process for their preparation, pharmaceutical compositions comprising them and their use in therapy as inhibitors of the phosphodiesterase IV (PDE4).

  揭示了具有化学结构式（I）的新（3-氧代）吡啶并嘧啶-4-基脲衍生物；以及它们的制备方法，包含它们的药物组合物以及它们作为磷酸二酯酶IV（PDE4）抑制剂在治疗中的用途。
• Raney copper
  申请人：Degussa-Huls AG

  公开号：US20020038051A1

  公开（公告）日：2002-03-28

  Raney copper which is doped with at least one metal from the group comprising iron and/or noble metals is used as a catalyst in the dehydrogenation of alcohols.

  含有铁和/或贵金属中至少一种金属的Raney铜被用作醇脱氢反应的催化剂。
• FUNCTIONAL SUBSTANCE-RELEASING AGENT
  申请人：Abe Hideyuki

  公开号：US20110015421A1

  公开（公告）日：2011-01-20

  The present invention relates to a functional substance-releasing agent containing a silicic acid ester compound represented by formula (1) below, a process for producing the functional substance-releasing agent, and a composition containing the functional substance-releasing agent. wherein R 1 represents a residue of an alcohol which results from removal of one hydroxyl group therefrom, the alcohol being selected from a functional alcohol having a log P value of 2.0 or less and an alcohol having a log P value of 2.1 or more, a plurality of R 1 s may be the same or different, provided that the silicic acid ester compound has, in one molecule, at least one residue resulting from removal of one hydroxyl group from a functional alcohol having a log P value of 2.0 or less and at least one residue resulting from removal of one hydroxyl group from an alcohol having a log P value of 2.1 or more.

  本发明涉及一种含有下式（1）所表示的硅酸酯化合物的功能性物质释放剂，以及制备该功能性物质释放剂的方法和含有该功能性物质释放剂的组合物。其中，R1代表从醇中除去一个羟基后得到的残基，所述醇被选择为具有2.0或以下的log P值的功能性醇和具有2.1或以上的log P值的醇之一，多个R1可以相同或不同，但所述硅酸酯化合物在一个分子中至少有一个残基是从具有2.0或以下的log P值的功能性醇中除去一个羟基得到的，至少有一个残基是从具有2.1或以上的log P值的醇中除去一个羟基得到的。