N-(4-hydroxy-3-methoxyphenethyl)octanamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: N-(4-hydroxy-3-methoxyphenethyl)octanamide
• 英文别名: N-[2-(4-hydroxy-3-methoxyphenyl)ethyl]octanamide
• 化学式: C₁₇H₂₇NO₃
• 分子量: 293.406
• InChiKey: CELHBAMWJAJIRF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  21
• 可旋转键数：
  10
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.59
• 拓扑面积：
  58.6
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  辛酸 、 4-(2-氨基乙基)-2-甲氧基苯酚 在 (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate 、 三乙胺 作用下， 以 四氢呋喃 为溶剂， 反应 16.0h， 以95%的产率得到N-(4-hydroxy-3-methoxyphenethyl)octanamide
  参考文献：
  名称：

  Radiofluorinated N-Octanoyl Dopamine ([¹⁸F]F-NOD) as a Tool To Study Tissue Distribution and Elimination of NOD in Vitro and in Vivo

  摘要：

  To mitigate pretransplantation injury in organs of potential donors, N-octanoyl dopamine (NOD) treatment might be considered as it does not affect hemodynamic parameters in braindead (BD) donors. To better assess optimal NOD concentrations for donor treatment, we report on the fast and facile radiofluorination of the NOD-derivative [F-18]F-NOD [F-18]5 for in vivo assessment of NOD's elimination kinetics by means of PET imaging. [F-18]5 was synthesized in reproducibly high radiochemical yields and purity (>98%) as well as high specific activities (>20 GBq/mu mol). Stability tests showed no decomposition of [F-18]5 over a period of 120 min in rat plasma. In-vitro, low cell association was found for [F-18]5, indicating no active transport mechanism into cells. In vivo, [F-18]5 exhibited a fast blood clearance and a predominant hepatobiliary elimination. As these data suggest that also NOD might be cleared fast, further pharmacokinetic evaluation is warranted.

  DOI：

  10.1021/acs.jmedchem.6b01191

文献信息

• BIRDFOOD CONTAINING CAPSAICIN OR ITS DERIVATIVES OR ANALOGUES
  申请人：THE UNITED STATES OF AMERICA as represented by the Secretary UNITED STATES DEPARTMENT OF COMMERCE

  公开号：EP0546078B1

  公开（公告）日：1999-02-24