1-[2-(2-furanyl)-3-hydroxy-4-oxo-4H-1-benzopyran-6-yl]-1H-pyrrole-2,5-dione | 1229030-44-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 1-[2-(2-furanyl)-3-hydroxy-4-oxo-4H-1-benzopyran-6-yl]-1H-pyrrole-2,5-dione
• 英文别名: MCF；1-[2-(Furan-2-yl)-3-hydroxy-4-oxochromen-6-yl]pyrrole-2,5-dione；1-[2-(furan-2-yl)-3-hydroxy-4-oxochromen-6-yl]pyrrole-2,5-dione
• CAS: 1229030-44-7
• 化学式: C₁₇H₉NO₆
• 分子量: 323.262
• InChiKey: PKNXHKBVDDNRTN-UHFFFAOYSA-N

物化性质

• 沸点：
  567.0±50.0 °C(predicted)
• 密度：
  1.633±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  24
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  97
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  N-乙酰-L-半胱氨酸 、 1-[2-(2-furanyl)-3-hydroxy-4-oxo-4H-1-benzopyran-6-yl]-1H-pyrrole-2,5-dione 以 N,N-二甲基甲酰胺 为溶剂， 以100%的产率得到AcCys-MCF
  参考文献：
  名称：

  Fluorescent Ratiometric MFC Probe Sensitive to Early Stages of α-Synuclein Aggregation

  摘要：

  We introduce a sensor molecule, AS140-MFC, consisting of a covalent adduct of an Ala-to-Cys mutant of alpha-synuclein with the 3-hydroxychromone dual emission dye MFC. We show that the AS140-MFC construct is a multiparametric fluorescent probe suitable for the continuous monitoring of protein aggregation and is sensitive to the early and intermediate stages of alpha-synuclein aggregation, a process associated with Parkinson's disease.

  DOI：

  10.1021/ja102838n
• 作为产物：
  描述：

  4-[[2-(2-furanyl)-3-hydroxy-4-oxo-4H-1-benzopyran-6-yl]amino]-4-oxo-2-butenoic acid 在 1-羟基苯并三唑 、 N,N'-二异丙基碳二亚胺 作用下， 以 水 、 N,N-二甲基甲酰胺 为溶剂， 以42%的产率得到1-[2-(2-furanyl)-3-hydroxy-4-oxo-4H-1-benzopyran-6-yl]-1H-pyrrole-2,5-dione
  参考文献：
  名称：

  Fluorescent Ratiometric MFC Probe Sensitive to Early Stages of α-Synuclein Aggregation

  摘要：

  We introduce a sensor molecule, AS140-MFC, consisting of a covalent adduct of an Ala-to-Cys mutant of alpha-synuclein with the 3-hydroxychromone dual emission dye MFC. We show that the AS140-MFC construct is a multiparametric fluorescent probe suitable for the continuous monitoring of protein aggregation and is sensitive to the early and intermediate stages of alpha-synuclein aggregation, a process associated with Parkinson's disease.

  DOI：

  10.1021/ja102838n

文献信息

• Fluorescent Ratiometric MFC Probe Sensitive to Early Stages of α-Synuclein Aggregation
  作者：Dmytro A. Yushchenko、Jonathan A. Fauerbach、Shyamala Thirunavukkuarasu、Elizabeth A. Jares-Erijman、Thomas M. Jovin

  DOI：10.1021/ja102838n

  日期：2010.6.16

  We introduce a sensor molecule, AS140-MFC, consisting of a covalent adduct of an Ala-to-Cys mutant of alpha-synuclein with the 3-hydroxychromone dual emission dye MFC. We show that the AS140-MFC construct is a multiparametric fluorescent probe suitable for the continuous monitoring of protein aggregation and is sensitive to the early and intermediate stages of alpha-synuclein aggregation, a process associated with Parkinson's disease.