1,3-dimethyl-6-phenyl-1H,8H-pteridine-2,4,7-trione | 50996-40-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 蝶啶及其衍生物
• 英文名称: 1,3-dimethyl-6-phenyl-1H,8H-pteridine-2,4,7-trione
• 英文别名: 7-hydroxy-1,3-dimethyl-6-phenyllumazine；7-hydroxy-1,3-dimethyl-6-phenyl-2,4(1H,3H)-pteridinedione；1,3-dimethyl-6-phenyl-8H-pteridine-2,4,7-trione
• CAS: 50996-40-2
• 化学式: C₁₄H₁₂N₄O₃
• 分子量: 284.274
• InChiKey: HWRZOCLCLPASEE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  21
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  82.1
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1,3-dimethyl-6-phenyl-1H,8H-pteridine-2,4,7-trione 在 硫酸二甲酯 作用下， 以 甲醇 、 sodium hydroxide 为溶剂， 以1.26 g (81%)的产率得到7-ethoxy-1,3-dimethyl-6-phenyllumazine
  参考文献：
  名称：

  Immunosuppressive effects of pteridine derivatives

  摘要：

  新型多取代的嘌呤二酮（ luminazenes ），以及单取代或多取代的2-噻唑嘌呤、4-噻唑嘌呤或2,4-二噻唑嘌呤，其嘌呤环的1、3、6和7位上具有已披露的取代基，以及它们的药用可接受盐，由通用公式（I）表示。 它们作为生物活性成分在制备药物组合物中特别有用，用于治疗或预防中枢神经系统疾病、细胞增殖性疾病、病毒感染、免疫或自身免疫性疾病或移植排斥。还披露了嘌呤衍生物与免疫抑制剂或免疫调节剂药物、抗肿瘤药物或抗病毒剂的组合，这些组合可能提供潜在的协同效应。

  公开号：

  US06946465B2
• 作为产物：
  描述：

  苯胺 、 1,3-Dimethylpteridin-2,4,7-trion 在 盐酸 、 sodium carbonate 、 sodium nitrite 作用下， 生成 1,3-dimethyl-6-phenyl-1H,8H-pteridine-2,4,7-trione 、 1,3-dimethyl-6-phenyl-7-phenoxylumazine
  参考文献：
  名称：

  Arylation of 1,3-Dimethyllumazines by Arenediazonium Salts

  摘要：

  Reaction of 7-methoxy-1,3-dimethyllumazine with benzenediazonium chloride in an alkaline aqueous solution afforded 6-phenyl- and 6-biphenyl-7-methoxy-1,3-dimethyllumazines. Treatment of 7-dimethylamino-1,3-dimethyllummazine with benzenediazonium chloride similarly gave the 6-phenyl and 6-biphenyl derivatives of the substrate together with 7-methylamino-6-phenyl-1,3-dimethyllumazine. Analogous reactions of 7-substituted 1,3-dimethyllumazines with several arenediazonium chlorides are described.

  DOI：

  10.3987/com-97-7748

文献信息

• Immunosuppresive effects of pteridine derivatives
  申请人：Waer Jozef Albert Mark

  公开号：US20070043000A1

  公开（公告）日：2007-02-22

  Novel poly-substituted pteridinediones (lumazines), and mono- or polysubstituted 2-thiolumazines, 4-thiolumazines or 2,4-dithiolumazines, having disclosed substituents in positions 1, 3, 6 and 7 of the pteridine ring, and pharmaceutically acceptable salts thereof, are useful as biologically active ingredients in preparing pharmaceutical compositions especially for the treatment or prevention of a CNS disorder, a cell proliferative disorder, a viral infection, an immune or auto-immune disorder or a transplant rejection. Combinations of the pteridine derivatives of the invention with an immunosuppressant or immunomodulator drug, an antineoplastic drug or an antiviral agent, providing potential synergistic effects, are also disclosed.

  新型多取代噻唑并二酮（吕马嗪），以及单取代或多取代的2-硫吕马嗪、4-硫吕马嗪或2,4-二硫吕马嗪，在噻嗪环的1、3、6和7位上具有已披露的取代基，以及其药学上可接受的盐，可用作制备药物组合物的活性成分，尤其适用于治疗或预防中枢神经系统疾病、细胞增殖紊乱、病毒感染、免疫或自身免疫性疾病或移植排斥。本发明的噻唑衍生物与免疫抑制剂或免疫调节剂、抗肿瘤药物或抗病毒药物的组合，提供潜在的协同作用。
• US6946465B2
  申请人：——

  公开号：US6946465B2

  公开（公告）日：2005-09-20
• Immunosuppressive effects of pteridine derivatives
  申请人：——

  公开号：US20030236255A1

  公开（公告）日：2003-12-25

  Novel poly-substituted pteridinediones (lumazines), and mono- or polysubstituted 2-thiolumazines, 4-thiolumazines or 2,4-dithiolumazines, having disclosed substituents in positions 1, 3, 6 and 7 of the pteridine ring, and pharmaceutically acceptable salts thereof, are useful as biologically active ingredients in preparing pharmaceutical compositions especially for the treatment or prevention of a CNS disorder, a cell proliferative disorder, a viral infection, an immune or auto-immune disorder or a transplant rejection. Combinations of the pteridine derivatives of the invention with an immunosuppressant or immunomodulator drug, an antineoplastic drug or an antiviral agent, providing potential synergistic effects, are also disclosed.

  新型多取代的喹啉二酮（卢马嗪），以及单取代或多取代的2-硫代卢马嗪，4-硫代卢马嗪或2,4-二硫代卢马嗪，在喹啉环的1、3、6和7位上具有已披露的取代基，并且其药学上可接受的盐，在制备药物组合物中作为生物活性成分特别用于治疗或预防中枢神经系统疾病、细胞增殖障碍、病毒感染、免疫或自身免疫障碍或移植排斥。本发明的喹啉衍生物与免疫抑制剂或免疫调节剂药物、抗肿瘤药物或抗病毒药物的组合，提供潜在的协同效应。
• Arylation of 1,3-Dimethyllumazines by Arenediazonium Salts
  作者：Takashi Sugimoto、Wolfgang Pfleiderer

  DOI：10.3987/com-97-7748

  日期：——

  Reaction of 7-methoxy-1,3-dimethyllumazine with benzenediazonium chloride in an alkaline aqueous solution afforded 6-phenyl- and 6-biphenyl-7-methoxy-1,3-dimethyllumazines. Treatment of 7-dimethylamino-1,3-dimethyllummazine with benzenediazonium chloride similarly gave the 6-phenyl and 6-biphenyl derivatives of the substrate together with 7-methylamino-6-phenyl-1,3-dimethyllumazine. Analogous reactions of 7-substituted 1,3-dimethyllumazines with several arenediazonium chlorides are described.