甲基硫酸乙酯 | 814-40-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机硫酸及其衍生物
• 中文名称: 甲基硫酸乙酯
• 英文名称: Ethyl-methyl-sulfat
• 英文别名: Sulfuric acid, ethyl methyl ester；ethyl methyl sulfate
• CAS: 814-40-4
• 化学式: C₃H₈O₄S
• 分子量: 140.16
• InChiKey: JKLNYGDWYRKFKR-UHFFFAOYSA-N

物化性质

• 沸点：
  199.27°C (estimate)
• 密度：
  1.2250

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  8
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  61
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  甲基硫酸乙酯 生成 硫酸二乙酯 、 硫酸二甲酯
  参考文献：
  名称：

  Levaillant, Annales de Chimie (Cachan, France), 1936, vol. <11>6, p. 524,525

  摘要：

  DOI：
• 作为产物：
  描述：

  乙基甲基亚硫酸酯 在 三氧化硫 作用下， 生成 甲基硫酸乙酯
  参考文献：
  名称：

  Pavlov,V.M. et al., Journal of general chemistry of the USSR, 1971, vol. 41, p. 2559 - 2561

  摘要：

  DOI：

文献信息

• Poly(4-vinylpyridine)-supported cationic bis(cyclopentadienyl)zirconocene catalyst: Development of a new simple method to prepare polymer-supported cationic zirconocene and its application to ethylene polymerization
  作者：Kittichote Musikabhumma、Toshiya Uozumi、Tsuneji Sano、Kazuo Soga

  DOI：10.1002/1521-3927(20000601)21:10<675::aid-marc675>3.0.co;2-i

  日期：2000.6.1

  Bis(cyclopentadienyl) zirconocene dimethyl (Cp 2 ZrMe 2 ) combined with triphenylcabenium tetrakis(pentafluorophenyl) borate ([Ph 3 C][B(C 6 F 5 ) 4 ]) was brought into contact with a suspension of 2% cross-linked poly(4-vinylpyridine) to give a new type of poilymer-supported cationic zirconocene catalyst. The resulting polymer-supported catalyst system combined with Al(i-Bu 3 ) showed markedly high

  双(环戊二烯基)锆茂二甲基(Cp 2 ZrMe 2 )与四(五氟苯基)硼酸三苯基卡宾鎓([Ph 3 C][B(C 6 F 5 ) 4 ])与2％交联的悬浮液接触聚（4-乙烯基吡啶），得到一种新型的聚合物负载的阳离子锆茂催化剂。所得聚合物负载的催化剂体系与 Al(i-Bu 3 ) 结合，即使在 25-60°C 和 [A1]/[Zr] 摩尔比为 40- 的非极性溶剂（如己烷）中也显示出显着的高乙烯聚合活性。 200。通过分析己烷溶液的ZR含量，发现溶液中没有检测到Zr，即没有阳离子催化剂浸出到己烷介质中。发现催化活性随着聚合温度的升高而增加，并在 [A1]/[Zr] = 100 时表现出最高。分子量，
• Dietary fatty acid modulation of mucosally-induced tolerogenic immune responses
  作者：Laurence S. Harbige、Benjamin A. C. Fisher

  DOI：10.1079/pns2001123

  日期：2001.11

  Immunological unresponsiveness or hyporesponsiveness (tolerance) can be induced by feeding protein antigens to naïve animals. Using a classical oral ovalbumin gut-induced tolerance protocol in BALB/c mice we investigated the effects of dietaryn-6 andn-3 polyunsaturated fatty acids (PUFA) on high-and low-dose oral tolerance (and in non-tolerised animals, i.e. effects of antigen challenge alone) in relation to lymphoproliferative, cytokine and antibody responses. Fish oil rich in long-chainn-3 fatty acids decreased both T-helper (Th) 1- and Th2-like responses. In contrast, borage (Borago officinalis) oil rich inn-6 PUFA, of which γ-linolenic acid is rapidly metabolised to longer-chainn-6 PUFA, increased Th1-like responses and decreased Th2-like responses, and possibly enhanced suppressor cell or Th3-like activity. These findings are in general agreement with other studies on the effects of long chainn-3 PUFA on immune system functions, and characterise important differences between long-chainn-3 andn-6 PUFA, defining more precisely and broadly the immunological regulatory mechanisms involved. They are also discussed in relation to autoimmune disease.

  免疫无反应性或低反应性（耐受性）可通过给天真动物喂食蛋白质抗原来诱导。我们在 BALB/c 小鼠中采用经典的口服卵清蛋白肠道诱导耐受方案，研究了膳食中 6 和 n-3 多不饱和脂肪酸（PUFA）对高剂量和低剂量口服耐受（以及对非耐受动物，即单独抗原挑战的影响）的影响，这些影响与淋巴细胞增殖、细胞因子和抗体反应有关。富含长链n-3脂肪酸的鱼油可降低T-辅助细胞（Th）1-和Th2-样反应。相反，富含inn-6 PUFA的琉璃苣（Borago officinalis）油（其中的γ-亚麻酸可迅速代谢为长链n-6 PUFA）则增加了Th1样反应，减少了Th2样反应，并可能增强了抑制细胞或Th3样活性。这些发现与其他关于长链 n-3 PUFA 对免疫系统功能影响的研究结果基本一致，并描述了长链 n-3 和 n-6 PUFA 之间的重要差异，更准确、更广泛地定义了其中涉及的免疫调节机制。还讨论了它们与自身免疫疾病的关系。
• 1,2-Dialkoxyacenaphthylenes and 2,3,11,12-bis-(1,2-acenaphtho)-[18]crown-6
  作者：A. Merz、F. Dietl、R. Tomahogh、G. Weber、G.M. Sheldrick

  DOI：10.1016/s0040-4020(01)91094-4

  日期：1984.1

  A general synthesis of 1,2-dialkoxyacenaphthylenes by dehydrogenation of the corresponding acenaphthene derivatives with high potential quinones is described. The new crown ether, 2,3,11,12-bis(1,2-acenaphtho)-[18]crown-6, 1, is obtained by this route. The surprisingly poor complexing ability of 1 is ascribed to electronic and geometrical effects of the acenaphthylene rings as shown by spectroscopic

  描述了通过用高电势醌将相应的衍生物进行脱氢来一般合成1，2-二烷氧基ac。通过该途径获得新的冠醚2,3,11,12-双（1,2-ac）-[18]冠-6-1。如光谱和伏安数据以及游离配体1的晶体结构所示，of 1的令人惊讶的较差的络合能力归因于the环的电子和几何效应。
• Sokol'skii,G.A., Journal of general chemistry of the USSR, 1966, vol. 36, p. 817 - 819
  作者：Sokol'skii,G.A.

  DOI：——

  日期：——
• Peroxisome Proliferator-Activated Receptor-γ Gene Expression in Orbital Adipose/Connective Tissues is Increased During the Active Stage of Graves' Ophthalmopathy
  作者：Lídia Y. Mimura、Sandra M.F. Villares、Mário L.R. Monteiro、Isabel C. Guazzelli、Walter Bloise

  DOI：10.1089/105072503322401032

  日期：2003.9

  The mechanisms involved in the increase of orbital retro-ocular adipose tissue that occurs in Graves' ophthalmopathy (GO) are still unclear. In this condition, the orbital tissue shows glycosaminoglycans deposition produced by activated fibroblasts capable of undergoing adipocytic differentiation. Many genes are involved in adipogenic mechanisms including the transcription factor peroxisome proliferator-activated receptor-gamma (PPAR-gamma). We evaluated the level of expression of the PPAR-gamma gene in normal and GO orbital adipose/connective tissue specimens using a quantitative and sensitive reverse transcription (RT) competitive polymerase chain reaction (PCR) assay. Our results show that the expression of PPAR-gamma was significantly greater in adipose/connective tissue from patients in the active stage of GO than in controls (150.8 +/- 103.9 and 24.0 +/- 4.9 amol/micro g of total RNA respectively, p < 0.05), while there was no significant difference between patients with inactive GO (58.8 +/- 40.6 aM/mug total RNA) and controls. These results suggest that increased PPAR-gamma gene expression in the active stage of GO may be dependent on the inflammatory process in this disease. We speculate that the increased orbital fat tissue observed in GO may be a consequence of the anti-inflammatory PPAR-gamma action.