Ethylene dichloride and carbon tetrachloride (7:3) | 8003-06-3

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 卤代烷
• 英文名称: Ethylene dichloride and carbon tetrachloride (7:3)
• 英文别名: 1,2-dichloroethane;tetrachloromethane
• CAS: 8003-06-3
• 化学式: C3H4Cl6
• 分子量: 252.8
• InChiKey: SPZCXVPOFSVCFS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.02
• 重原子数：
  9
• 可旋转键数：
  1
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为试剂：
  描述：

  甲基甲基硫代甲砜 、 sodium;hydride 、 苯甲腈 、 水 在 ice 、 Sodium sulfate-III 、 Ethylene dichloride and carbon tetrachloride (7:3) 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 20.0h， 以Thus 2.391 g of 1-methylsulfinyl-1-methylthio-2-amino-2-phenylethylene was obtained的产率得到1-Methylsulfinyl-1-methylthio-2-amino-2-phenylethylene
  参考文献：
  名称：

  Aromatic enaminosulfoxide derivatives

  摘要：

  式为##STR1##的Enaminosulfoxides，其中R.sup.1是烷基，二烷氧基烷基，苯基烷基，苯基，卤代苯基，烷基苯基，烷氧基苯基或二烷氧基苯基基团，所述烷基和烷氧基每个含有1至4个碳原子，每个R.sup.2分别独立地是1至4个碳原子的烷基，苯基，甲苯基或氯苯基基团，其中至少一个R.sup.1和R.sup.2是芳香族的。这些化合物可用于合成已知有用途的酮酸衍生物和酰基氨基酸酯。

  公开号：

  US04002682A1

文献信息

• Novel 6-chloro-2-(4,6-dimethoxypyrimidin-2-yl) oxybenzoic acid ester derivatives, processes for their production an a method for their application as herbicides
  申请人：LUCKY LTD.

  公开号：EP0608862A1

  公开（公告）日：1994-08-03

  The present invention relates to novel 6-chloro-2-(4,6-dimethoxypyrimidin-2-yl)oxybenzoic acid iminoester derivative of the general formula(I); processes for their preparation and a method for their application as herbicides:    Therein, Q represents a straight or branched alkyl, alkenyl or cycloalkyl group having from 1 to 10 carbon atoms, preferably from 1 to 8 carbon atoms, which may be substituted with a (C₁-C₄)alkoxy or (C₁-C₄)alkylthio group; a (C₁-C₄)alkyl or (C₂-C₄)alkenylthio group; a phenylthio group; a phenyl(C₁-C₄)alkyl or phenyl(C₂-C₄)alkenylthio group; or a radical of the following formula:    [wherein R¹ and R² are same or different each other and represent hydrogen or a halogen atom; or a group selected from the groups which comprised with a (C₁-C₄)alkyl, a (C₂-C₄)alkenyl, an acyl, an acyloxy, a (C₁-C₄)alkylthio, a nitro, a cyano, a phenyl and a phenoxy group, and which, if necessary, may be substituted with a halogen atom, a (C₁-C₄)alkyl, a (C₁-C₄)alkoxy or an acetal group; or R¹ and R² may constitute an acetal structure with carbon atoms to which R1 and R² are linked.; and, n is 0 or 1.]; or a 5-6 membered ring system containing one or more hetero atoms such as oxygen, sulfur or nitrogen atom in the ring system, which may have one or more proper substituents such as a halogen atom, a (C₁-C₄)alkyl, a hydroxy, a nitro or a cyano group on its certain positions.; and,    R represents a hydrogen or a halogen atom, a cyano group, or -Z -R³ [wherein, R³ represents a (C₁-C₄)alkyl, an alkoxy or alkenyloxyl group having from 1 to 8 carbon atoms, or a phenyl, a phenoxy or an amino group, or 5-6 membered hetero or aromatic ring system connecting to Z through out a (C₁-C₂)alkyl or alkoxy bridge, such as a phenyl, a furyl, a thienyl, pyrrolyl or pyranyl group, and which may have one or more proper substituents such as a halogen atom, a (C₁-C₄)alkyl, a hydroxy, a nitro or a cyano group on its certain positions, or R³ may be cyclized with Z and Q in some cases.; and, Z represents -O-, -S-, [wherein, R⁴ is a hydrogen atom, a (C₁-C₄)alkyl or a phenyl group, or constitutes a cyclic system containing an oxygen atom with R³]].

  本发明涉及一种新型的一般式(I)的6-氯-2-(4,6-二甲氧基嘧啶-2-基)氧基苯甲酸亚氨酯衍生物；它们的制备方法以及作为除草剂的应用方法：其中，Q代表具有1至10个碳原子的直链或支链烷基、烯基或环烷基，最好为具有1至8个碳原子的烷基，可以用(C₁-C₄)烷氧基或(C₁-C₄)烷硫基取代；(C₁-C₄)烷基或(C₂-C₄)烯基硫基；苯硫基；苯(C₁-C₄)烷基或苯(C₂-C₄)烯基硫基；或以下式的基团：[其中R¹和R²相同或不同，分别代表氢或卤素原子；或从由(C₁-C₄)烷基、(C₂-C₄)烯基、酰基、酰氧基、(C₁-C₄)烷硫基、硝基、氰基、苯基和苯氧基组成的群中选取的一种群，必要时可以用卤素原子、(C₁-C₄)烷基、(C₁-C₄)烷氧基或缩醛基取代；或R¹和R²可以构成与R1和R²连接的碳原子的缩醛结构；n为0或1]；或在环系统中含有一个或多个杂原子（如氧、硫或氮原子）的5-6元环系统，可以在其特定位置上具有一个或多个适当的取代基，如卤素原子、(C₁-C₄)烷基、羟基、硝基或氰基；R代表氢或卤素原子、氰基，或-Z-R³；其中，R³代表具有1至8个碳原子的(C₁-C₄)烷基、烷氧基或烯氧基，或苯、苯氧基或氨基，或通过(C₁-C₂)烷基或烷氧基桥连接到Z的5-6元杂原子或芳香环系统，如苯基、呋喃基、噻吩基、吡咯基或吡喃基，并且可以在其特定位置上具有一个或多个适当的取代基，如卤素原子、(C₁-C₄)烷基、羟基、硝基或氰基；或在某些情况下，R³可以与Z和Q环化；Z代表-O-、-S-，其中R⁴为氢原子、(C₁-C₄)烷基或苯基，或构成含氧原子的环系统与R³结合。
• Indole derivatives as serotonin reuptake inhibitors
  申请人：Heinrich Timo

  公开号：US20070099933A1

  公开（公告）日：2007-05-03

  Compounds of the formula (I), the use thereof for the preparation of a medicament for the treatment of diseases associated with the serotonin receptor and/or serotonin reuptake, in particular for the preparation of a medicament as anxiolytic, antidepressant, neuroleptic and/or antihypertonic and/or for positively influencing obsessive-compulsive disorder (OCD), sleeping disorders, tardive dyskinesia, learning disorders, age-dependent memory disorders, eating disorders, such as bulimia, and/or sexual dysfunctions. The compounds bind to the 5-HT 1A receptor

  公式（I）的化合物，其用途为制备用于治疗与血清素受体和/或血清素再摄取有关的疾病的药物，特别是用于制备抗焦虑、抗抑郁、神经病理和/或抗高血压的药物，以及/或用于积极影响强迫症、睡眠障碍、迟发性运动障碍、学习障碍、年龄相关的记忆障碍、进食障碍，如暴食症，以及/或性功能障碍。这些化合物与5-HT1A受体结合。
• Pyridinamide derivatives as kinase inhibitors
  申请人：Burgdorf Lars

  公开号：US20070142440A1

  公开（公告）日：2007-06-21

  The invention relates to substituted arylamide derivatives of the formula I, the preparation and use thereof for the preparation of a medicament for the treatment of diseases, in particular tumours and/or diseases that are caused, mediated and/or propagated by angiogenesis. Compounds of the formula I are effective inhibitors of tyrosine kinases, in particular TIE-2 and VEGFR, and of Raf kinases.

  本发明涉及公式I的取代芳基酰胺衍生物，其制备和用途，用于制备治疗疾病的药物，特别是治疗肿瘤和/或由血管生成引起、介导和/或传播的疾病。公式I的化合物是有效的酪氨酸激酶抑制剂，特别是TIE-2和VEGFR以及Raf激酶。
• Process for producing phospholipid-containing drug
  申请人：——

  公开号：US20030185878A1

  公开（公告）日：2003-10-02

  The present invention provides a pharmaceutical preparation which is safe, little irritate subjects and comprises a water-insoluble or hardly water-soluble drug at a high level, and a simple and convenient process for producing the preparation. A process for producing a pharmaceutical composition comprising a water-insoluble or hardly water-soluble drug coated with phospholipid, said process comprising mixing a solution containing the water-insoluble or hardly water-soluble drug and phospholipid in an organic solvent with an aqueous solvent, emulsifying the resultant mixture and removing the organic solvent from the emulsion thus obtained to form a phospholipid coating film on the surface of the water-insoluble or hardly water-soluble drug.

  本发明提供了一种制药制剂，该制剂安全、对受试者刺激小，并且包含高水平的难溶于水或几乎不溶于水的药物，以及一种简单方便的制备过程。一种制备含有磷脂质包被的难溶于水或几乎不溶于水的药物的制药组合物的方法，该方法包括将含有难溶于水或几乎不溶于水的药物和磷脂质的溶液与有机溶剂混合后与水溶液乳化，然后从所得乳液中去除有机溶剂，以在难溶于水或几乎不溶于水的药物表面形成磷脂质包被膜。
• Process for the preparation of active-type vitamin D3 compounds and of the cholesta-5,7-diene precursors, and products so obtained
  申请人：TEIJIN LIMITED

  公开号：EP0028484A1

  公开（公告）日：1981-05-13

  The present invention relates to a novel process for the preparation of active-type vitamin D3 compounds and their intermediates. In accordance with the present invention, a large amount of an active-type vitamin D3 compound, for example 1α-hydroxycholecalciferol, 1α,25-dihydrox- ycholecalciferol and the like, is efficiently prepared with high industrial advantage by a novel process which comprises (i) reacting hydroxycholesta-5-enes having the hydroxyl groups protected with lower alkoxycarbonyl groups as a starting material with an allylic brominating agent and a dehydrobrominating agent to prepare the corresponding hydroxycholesta-5,7-dienes, (ii) exposing the hydroxycholesta-5,7-dienes to ultraviolet irradiation or to a combination of the irradiation with thermal isomerization to obtain a mixture of the unreacted hydroxycholesta-5,7-dienes and previtamin D3 compounds or a mixture of the unreacted hydroxycholesta-5,7-dienes and the protected active-type vitamin D, compounds, (iii) separating the mixture into the unreacted hydroxycholesta-5,7-dienes and previtamin D3 compounds or the protected active-type vitamin D3 compounds, (iv) recycling the unreacted hydroxycholesta-5,7-dienes for reuse and (v) thermally isomerizing the remaining compounds and/or splitting off the protective groups. The process of the invention is of very high industrial value, capable of simple operation and adaptable to large scale commercial production.

  本发明涉及一种制备活性型维生素 D3 化合物及其中间体的新工艺。根据本发明，大量活性型维生素 D3 化合物，例如 1α-羟基胆钙化醇、1α,25-二羟基胆钙化醇等、该工艺包括：(i) 以羟基被低级烷氧羰基保护的羟基胆甾烷-5-烯为起始原料，与烯丙基溴化剂和脱氢溴化剂反应，制备相应的羟基胆甾烷-5,7-二烯；(ii) 将羟基胆甾烷-5、(ii) 将羟基胆甾烷-5,7-二烯置于紫外线辐照下，或将辐照与热异构化相结合，以获得未反应的羟基胆甾烷-5,7-二烯与前维生素 D3 化合物的混合物，或未反应的羟基胆甾烷-5,7-二烯与受保护的活性型维生素 D 化合物的混合物、(iii) 将混合物分离为未反应的羟基胆甾烷-5,7-二烯和前维生素 D3 化合物或受保护的活性型维生素 D3 化合物， (iv) 回收未反应的羟基胆甾烷-5,7-二烯以供再利用， (v) 对剩余化合物进行热异构化和/或分离保护基团。本发明的工艺具有极高的工业价值，操作简单，可适应大规模商业生产。