2-[10,15,20-Tris(2-aminophenyl)porphyrin-5-yl]aniline

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 四吡咯及其衍生物
• 英文名称: 2-[10,15,20-Tris(2-aminophenyl)porphyrin-5-yl]aniline
• 化学式: C₄₄H₃₂N₈
• 分子量: 672.8
• InChiKey: PRGKCXVWHIZSPE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.9
• 重原子数：
  52
• 可旋转键数：
  4
• 环数：
  9.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  154
• 氢给体数：
  4
• 氢受体数：
  8

文献信息

• Electrode for active oxygen species and sensor using the electrode
  申请人：Yuasa Makoto

  公开号：US20050077192A1

  公开（公告）日：2005-04-14

  An electrode for active oxygen species comprising a conductive component with a polymer membrane of a metal porphyrin complex formed on the surface is disclosed. The electrode for active oxygen species can detect active oxygen species such as superoxide anion radicals, hydrogen peroxide, and .OH and other active radical species (NO, ONOO—, etc.) in any environment including in vivo environment as well as in vitro environment. The electrode thus can be used for specifying various diseases and examining active oxygen species in food or in water such as tap water and sewage water.

  本发明公开了一种活性氧物种电极，其包括一个导电组件和形成在其表面上的金属卟啉复合物聚合物膜。该活性氧物种电极可以检测任何环境中的活性氧物种，包括体内环境和体外环境中的超氧阴离子自由基、过氧化氢和.OH等活性自由基物种（NO、ONOO-等）。因此，该电极可用于指定各种疾病，并检查食品或水中的活性氧物种，如自来水和污水。
• ELECTRODE FOR ACTIVE OXYGEN SPECIES AND SENSOR USING THE ELECTRODE
  申请人：YUASA Makoto

  公开号：US20110315551A1

  公开（公告）日：2011-12-29

  An electrode for active oxygen species comprising a conductive component with a polymer membrane of a metal porphyrin complex formed on the surface is disclosed. The electrode for active oxygen species can detect active oxygen species such as superoxide anion radicals, hydrogen peroxide, and .OH and other active radical species (NO, ONOO—, etc.) in any environment including in vivo environment as well as in vitro environment. The electrode thus can be used for specifying various diseases and examining active oxygen species in food or in water such as tap water and sewage water.

  公开了一种用于活性氧物种的电极，其中包括一个导电组分和在其表面形成的金属卟啉复合物的聚合物膜。该电极可以检测任何环境中的活性氧物种，包括体内环境和体外环境中的超氧阴离子自由基、过氧化氢、.OH和其他活性自由基物种（NO、ONOO—等）。因此，该电极可用于指定各种疾病并检查食品或水中的活性氧物种，例如自来水和污水。
• Oxygen-adsorbing and desorbing agent
  申请人：TAIHO PHARMACEUTICAL CO., LTD.

  公开号：EP0066884A2

  公开（公告）日：1982-12-15

  A liposome formed of at least one lipid, or a mixture of at least one lipid and cholesterol and having enclosed therein an iron[II]-5,10,15,20-tetra(α,α,α,α-o-substituted amidophenyl)porphyrin-imidazol complex.

  一种由至少一种脂质或至少一种脂质与胆固醇的混合物形成的脂质体，其中包有铁[II]-5,10,15,20-四(α,α,α,α-o-取代的氨基苯基)卟啉-咪唑络合物。
• Iron-tetraphenylporphine complex having phosphocholine group and oxygen adsorbing and desorbing agent
  申请人：TAIHO PHARMACEUTICAL CO., LTD.

  公开号：EP0110396A2

  公开（公告）日：1984-06-13

  Disclosed is an iron-5,10,15,20-tetra(a,a,a,a,-o-substituted phenyl)porphine complex having one or four substituents with a phosphocholine group at the terminal end thereof. The substituents are positioned ortho of the phenyl group or groups. The complex is particularly useful as an oxygen adsorbing and desorbing agent.

  本发明公开了一种铁-5,10,15,20-四(a,a,a,a,-o-取代苯基)卟吩络合物，该络合物具有一个或四个取代基，其末端具有膦胆碱基团。取代基位于一个或多个苯基的正交位置。这种络合物尤其可用作氧气吸附剂和解吸附剂。
• Porphyrins and cancer treatment
  申请人：EFAMOL LIMITED

  公开号：EP0186962A1

  公开（公告）日：1986-07-09

  This invention provides for therapy of tumours susceptible to nectoris when an appropriate compound is administered followed by illumination with light of a wavelength absorbed by the compound, making use of meso-porphyrins of the formula: where n = 1 to 3 and each substituent R, the same or different and at the same or different position in its respective substituent phenyl ring or other aromatic group replacing that ring, is an hydroxy, amino or sulphydryl group, by association of said meso-porphyrins with a suitable pharmaceutical diluent or carrier.

  本发明提供了利用式中的介卟啉治疗易发生瘤变的肿瘤的方法，即先给药适当的化合物，然后用该化合物吸收的波长的光照射： 其中n＝1至3，每个取代基R（相同或不同且位于其各自取代基苯基环或取代该环的其它芳香基团的相同或不同位置）是羟基、氨基或巯基，通过将所述介卟啉与合适的药物稀释剂或载体结合。