N,N-diethyl-2-[5-[5-(2-methylpropanoylamino)pyridin-3-yl]-2H-pyrazolo[3,4-b]pyridin-3-yl]-3a,7a-dihydro-3H-imidazo[4,5-c]pyridine-7-carboxamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: N,N-diethyl-2-[5-[5-(2-methylpropanoylamino)pyridin-3-yl]-2H-pyrazolo[3,4-b]pyridin-3-yl]-3a,7a-dihydro-3H-imidazo[4,5-c]pyridine-7-carboxamide
• 化学式: C₂₆H₂₉N₉O₂
• 分子量: 499.6
• InChiKey: OXSIQTRKIDWBHT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  37
• 可旋转键数：
  7
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  141
• 氢给体数：
  3
• 氢受体数：
  7

文献信息

• [EN] 1H-PYRAZOLO[3,4-B]PYRIDINES AND THERAPEUTIC USES THEREOF<br/>[FR] 1H-PYRAZOLO[3,4-B]PYRIDINES ET LEURS UTILISATIONS THÉRAPEUTIQUES
  申请人：SAMUMED LLC

  公开号：WO2013166396A2

  公开（公告）日：2013-11-07

  Provided herein are compounds according to Formulas (I) or (II) and pharmaceutically acceptable salts thereof, and compositions comprising the same, for use in various methods, including treating cancer, abnormal cellular proliferation, angiogenesis, Alzheimer's disease, lung disease, osteoarthritis, idiopathic pulmonary fibrosis and neurological conditions/disorders/diseases. Formula (I) and (II).