[2-Amino-5-(3,4-dimethoxyphenyl)-4-oxofuran-3-yl] benzenesulfonate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: [2-Amino-5-(3,4-dimethoxyphenyl)-4-oxofuran-3-yl] benzenesulfonate
• 英文别名: [2-amino-5-(3,4-dimethoxyphenyl)-4-oxofuran-3-yl] benzenesulfonate
• 化学式: C₁₈H₁₇NO₇S
• 分子量: 391.4
• InChiKey: USJCDHLBHAYGSR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  27
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  123
• 氢给体数：
  1
• 氢受体数：
  8

文献信息

• 2, 6-Dinitrogen-Containing Substituted Purine Derivatives, The Preparation And Uses Thereof
  申请人：Wu Zhanggui

  公开号：US20100144663A1

  公开（公告）日：2010-06-10

  The present invention provides 2,6-dinitrogen-containing substituted purine compounds of formula (A) or salts or solvates thereof or the solvates of salts thereof, as well as pharmaceutical compositions containing such compounds. The compounds of the present invention have the characteristics of lower toxicity, broad anticancer spectrum, higher anticancer activity, good stability and the like. The compounds are useful for the manufacture of an antitumor medicament. The present invention also provides a process for preparing these compounds.

  本发明提供了具有式(A)的2,6-二氮代取代嘌呤化合物或其盐或溶剂合物或其盐的溶剂，以及含有这种化合物的药物组合物。本发明的化合物具有低毒性、广泛的抗癌谱、较高的抗癌活性、良好的稳定性等特点。这些化合物可用于制造抗肿瘤药物。本发明还提供了制备这些化合物的方法。
• Inhibitors of beta-hydroxylase for treatment of cancer
  申请人：MIDWESTERN UNIVERSITY

  公开号：US10106532B2

  公开（公告）日：2018-10-23

  The present invention relates to compounds which modulate (e.g., inhibit) the activity of beta-hydrolase (e.g., ASPH), including novel 2-aryl-5-amino-3(2H)-furanone and 2-heteroaryl-5-amino-3(2H)-furanone compounds, pharmaceutical compositions thereof, methods for their synthesis, and methods of using these compounds to modulate the activity of ASPH in an a cell-free sample, a cell-based assay, and in a subject. Other aspects of the invention relate to use of the compounds disclosed herein to ameliorate or treat cell proliferation disorders.

  本发明涉及调节（如抑制）β-水解酶（如ASPH）活性的化合物，包括新型2-芳基-5-氨基-3(2H)-呋喃酮和2-杂芳基-5-氨基-3(2H)-呋喃酮化合物、其药物组合物、其合成方法以及使用这些化合物调节无细胞样本、基于细胞的测定和受试者体内ASPH活性的方法。本发明的其他方面涉及使用本文公开的化合物来改善或治疗细胞增殖障碍。
• INHIBITORS OF BETA-HYDROLASE FOR TREATMENT OF CANCER
  申请人：Rhode Island Hospital

  公开号：EP2897607A2

  公开（公告）日：2015-07-29
• Inhibitors of Beta-Hydroxylase for Treatment of Cancer
  申请人：MIDWESTERN UNIVERSITY

  公开号：US20180009798A1

  公开（公告）日：2018-01-11

  The present invention relates to compounds which modulate (e.g., inhibit) the activity of beta-hydrolase (e.g., ASPH), including novel 2-aryl-5-amino-3(2H)-furanone and 2-heteroaryl-5-amino-3(2H)-furanone compounds, pharmaceutical compositions thereof, methods for their synthesis, and methods of using these compounds to modulate the activity of ASPH in an a cell-free sample, a cell-based assay, and in a subject. Other aspects of the invention relate to use of the compounds disclosed herein to ameliorate or treat cell proliferation disorders.
• [EN] INHIBITORS OF BETA-HYDROLASE FOR TREATMENT OF CANCER<br/>[FR] INHIBITEURS DE BÊTA-HYDROLASE POUR LE TRAITEMENT DU CANCER
  申请人：RHODE ISLAND HOSPITAL

  公开号：WO2014047519A2

  公开（公告）日：2014-03-27

  The present invention relates to compounds which modulate (e.g., inhibit) the activity of beta-hydrolase (e.g., ASPH), including novel 2-aryl-5-amino-3(2H)-furanone and 2- heteroaryl-5-amino-3(2H)-furanone compounds, pharmaceutical compositions thereof, methods for their synthesis, and methods of using these compounds to modulate the activity of ASPH in an a cell-free sample, a cell-based assay, and in a subject. Other aspects of the invention relate to use of the compounds disclosed herein to ameliorate or treat cell proliferation disorders.