ethyl 6-amino-5-cyano-2-(2,6-dichloro-5-fluoropyridin-3-yl)-4-(2-fluoro-4-methylphenyl)-4H-pyran-3-carboxylate | 1248444-41-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: ethyl 6-amino-5-cyano-2-(2,6-dichloro-5-fluoropyridin-3-yl)-4-(2-fluoro-4-methylphenyl)-4H-pyran-3-carboxylate
• CAS: 1248444-41-8
• 化学式: C₂₁H₁₅Cl₂F₂N₃O₃
• 分子量: 466.271
• InChiKey: AIKOFTVHNZTNSD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  31
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  98.2
• 氢给体数：
  1
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  2-(2-fluoro-4-methylbenzylidene)malononitrile 、 ethyl 3-(2,6-dichloro-5-fluoropyridin-3-yl)-3-oxopropanoate 在 哌啶 作用下， 以 乙醇 为溶剂， 反应 0.03h， 以85%的产率得到ethyl 6-amino-5-cyano-2-(2,6-dichloro-5-fluoropyridin-3-yl)-4-(2-fluoro-4-methylphenyl)-4H-pyran-3-carboxylate
  参考文献：
  名称：

  One-pot synthesis of polyfunctionalized 4H-pyran derivatives bearing fluorochloro pyridyl moiety

  摘要：

  Polyfunctionalized 4H-pyran derivatives bearing fluorochloro pyridyl moiety were readily prepared in high yields via one-pot multicomponent reaction catalyzed by piperidine. This present protocol provides an efficient synthetic route to the target compounds with the characteristics of short reaction time, high yield, and easy separation of the products. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.07.065

文献信息

• One-pot synthesis of polyfunctionalized 4H-pyran derivatives bearing fluorochloro pyridyl moiety
  作者：Zhenjun Ye、Renbo Xu、Xusheng Shao、Xiaoyong Xu、Zhong Li

  DOI：10.1016/j.tetlet.2010.07.065

  日期：2010.9

  Polyfunctionalized 4H-pyran derivatives bearing fluorochloro pyridyl moiety were readily prepared in high yields via one-pot multicomponent reaction catalyzed by piperidine. This present protocol provides an efficient synthetic route to the target compounds with the characteristics of short reaction time, high yield, and easy separation of the products. (C) 2010 Elsevier Ltd. All rights reserved.