N-[3-[[6-(3-methylanilino)pyrimidin-4-yl]amino]phenyl]cyclopropanecarboxamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-[3-[[6-(3-methylanilino)pyrimidin-4-yl]amino]phenyl]cyclopropanecarboxamide
• 化学式: C₂₁H₂₁N₅O
• 分子量: 359.4
• InChiKey: RGYMWEDCVGWMFZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  27
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  78.9
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• CARDIAC GLYCOSIDES ARE POTENT INHIBITORS OF INTERFERON-BETA GENE EXPRESSION
  申请人：Ye Junqiang

  公开号：US20140088056A1

  公开（公告）日：2014-03-27

  The invention provides for a method of inhibiting interferon-beta gene expression and/or reducing the level of interferon-beta in a cell by contacting the cell with a Na + , Ca 2+ , or K + ion-channel modulator. The invention also provides for a method of treating a disease or disorder characterized by elevated interferon beta levels or elevated levels of interferon-beta gene expression. Additionally, the invention provides a method for treating pathogenic or non-pathogenic infections.