2,4-Bis[2-(prop-2-enoylamino)ethyl]pyridine-3,5-dicarboxamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2,4-Bis[2-(prop-2-enoylamino)ethyl]pyridine-3,5-dicarboxamide
• 英文别名: 2,4-bis[2-(prop-2-enoylamino)ethyl]pyridine-3,5-dicarboxamide
• 化学式: C₁₇H₂₁N₅O₄
• 分子量: 359.4
• InChiKey: BLGVXWQJQVLCOB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1
• 重原子数：
  26
• 可旋转键数：
  10
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  157
• 氢给体数：
  4
• 氢受体数：
  5

文献信息

• NOVEL CROSS-LINKERS FOR HYDROGELS, HYDROGELS INCLUDING THESE CROSS-LINKERS AND APPLICATIONS THEREOF
  申请人：MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V.

  公开号：US20150240037A1

  公开（公告）日：2015-08-27

  The present invention relates to novel cross-linkers for hydrogels, in particular for hyaluronan hydrogels, corresponding hydrogels including said cross-linkers and various applications thereof. The cross linker of the invention is a bi- or multifunctional cross-linker comprising or consisting of an aromatic or heteroaromatic ring system with 3-6 C atoms which is coupled via functional groups on at least 2 ring positions with at least 2 terminal groups capable to form a covalent bond with thiol or amino groups, in particular with thiol groups in a thiol-en reaction. The cross-linker may be charged or uncharged. In a specific embodiment, the terminal groups are coupled to carboxy groups of the aromatic or heteroaromatic ring system via an ester or amide bond. More specifically, the cross-linker of the invention is a derivative of pyridine-3,5-dicarboxylic acid or a corresponding pyridinium salt thereof wherein 2 terminal groups are coupled to the carboxy groups of the pyridine or pyridinium core via an ester or amide amidoethyl)carbamoyl)-1-methylpyridin-1-ium-halogenide.

  本发明涉及新型的交联剂，特别是用于透明质酸水凝胶的交联剂，包括所述交联剂的对应水凝胶及其各种应用。该发明的交联剂是一种双或多功能的交联剂，包括或由具有3-6个碳原子的芳香或杂芳环系统组成，该环系统通过至少2个环位置的功能基团与至少2个末端基团耦合，能够与巯基或氨基形成共价键，特别是与巯基在巯基-烯丙基反应中形成共价键。交联剂可以带电或不带电。在特定的实施例中，末端基团通过酯或酰胺键与芳香或杂芳环系统的羧基耦合。更具体地说，该发明的交联剂是吡啶-3,5-二羧酸或其相应的吡啶盐衍生物，其中2个末端基团通过酯或酰胺键与吡啶或吡啶核心的羧基耦合，例如（2-氨基乙基）-氨基甲酰基）-1-甲基吡啶-1-ium-卤化物。
• Intraocular device and method for preparing the same
  申请人：Max-Planck-Gesellschaft zur Foerderung der Wissenschaften e. V.

  公开号：US10898619B2

  公开（公告）日：2021-01-26

  The present invention relates to an ocular device for regulating intraocular fluid pressure comprising or consisting of a tubular body wherein the inner surface of the tubular body or the inner and outer surface is/are coated with covalently immobilized hyaluronic acid (HA). In more specific embodiments, the tubular body comprises or consists of a biocompatible material selected from the group comprising a biocompatible metal such as titanium, ceramics, glass, polymers and composites thereof, and the immobilized hyaluronic acid molecules are linked with further HA molecules to form a HA hydrogel. The ocular device is a stent free from mechanical valves or other mechanical means for actively regulating the flow of intraocular fluid.

  本发明涉及一种用于调节眼内液压力的眼部装置，该装置包括或由管状体组成，其中管状体的内表面或内外表面涂有共价固定的透明质酸（HA）。在更具体的实施方案中，管状体包括或由选自生物相容性金属（如钛）、陶瓷、玻璃、聚合物及其复合材料组的生物相容性材料组成，固定化透明质酸分子与其他 HA 分子连接形成 HA 水凝胶。该眼科装置是一种支架，不含机械阀门或其他用于主动调节眼内液体流动的机械装置。
• "NOVEL CROSS-LINKERS FOR HYDROGELS, HYDROGELS INCLUDING THESE CROSS-LINKERS AND APPLICATIONS THEREOF"
  申请人：Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.

  公开号：EP2900636A1

  公开（公告）日：2015-08-05
• INTRAOCULAR DEVICE AND METHOD FOR PREPARING THE SAME
  申请人：Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.

  公开号：EP3115031B1

  公开（公告）日：2021-12-22
• US9644076B2
  申请人：——

  公开号：US9644076B2

  公开（公告）日：2017-05-09