2-(1,3-Thiazol-2-ylmethyl)benzonitrile

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(1,3-Thiazol-2-ylmethyl)benzonitrile
• 英文别名: 2-(1,3-thiazol-2-ylmethyl)benzonitrile
• 化学式: C₁₁H₈N₂S
• 分子量: 200.26
• InChiKey: DAUSFRNLKKVTPB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  64.9
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• Precursor molecule for the synthesis of D-luciferin
  申请人：Ecole Polytechnique Fédérale de Lausanne (EPFL)

  公开号：EP2719703A1

  公开（公告）日：2014-04-16

  The present invention relates to precursor molecules for the synthesis of D-luciferin, or blocked D-luciferin, which are functionalised in different positions. Further, the use of functionalised precursor molecules for the synthesis of D-luciferin or blocked D-luciferin and methods of synthesising blocked D-luciferin and D-luciferin are described. Also described is a kit of parts for screening assay comprising said functionalised precursor molecules to D-luciferin or blocked D-luciferin and the uses of such a screening assay for the detection of molecules for the study of molecular uptake and for the detection of a reducing environment. Methods of detection bio- molecules and for determining a sequence within a peptide of protein cleaved by specific enzymes are described. Also a method of determining the cysteine concentration in a cell or tissue sample is described. Precursor molecules of D-luciferin according to the invention are advantageous as they are small and travel easily around live systems and allow tissue cells or organs to be targeted specifically. Further, the methods and screening assays described allow the simultaneous study of multiple biological processes in one experiment only.

  本发明涉及用于合成D-荧光素或封端D-荧光素的前体分子，这些前体分子在不同位置上被官能化。此外，还描述了使用功能化前体分子合成 D-荧光素或封端 D-荧光素的方法，以及合成封端 D-荧光素和 D-荧光素的方法。此外，还介绍了一种用于筛选检测的部件套件，该套件包括上述 D-荧光素或封端 D-荧光素的官能化前体分子，以及这种筛选检测在分子吸收研究和还原环境检测方面的用途。描述了检测生物分子和确定被特定酶裂解的蛋白质肽内序列的方法。此外，还介绍了一种确定细胞或组织样本中半胱氨酸浓度的方法。根据本发明，D-荧光素的前体分子是有利的，因为它们很小，很容易在活的系统中移动，并允许组织细胞或器官被特异性地靶向。此外，所述方法和筛选测定只需一次实验即可同时研究多个生物过程。
• [EN] PRECURSOR MOLECULE FOR THE SYNTHESIS OF D-LUCIFERIN<br/>[FR] MOLÉCULE PRÉCURSEUR POUR LA SYNTHÈSE DE LA D-LUCIFÉRINE
  申请人：ECOLE POLYTECH

  公开号：WO2014057139A2

  公开（公告）日：2014-04-17

  The present invention relates to precursor molecules for the synthesis of D-luciferin, or blocked D-luciferin and derivatives thereof, which are functionalized in different positions. Further, the use of functionalized precursor molecules for the synthesis of D-luciferin or blocked D-luciferin and methods of synthesising blocked D-luciferin and D-luciferin or derivatives thereof are described. Also described is a kit of parts for screening assay comprising said functionalized precursor molecules to D-luciferin or blocked D-luciferin and derivatives thereof and the uses of such a screening assay for the detection of molecules for the study of molecular uptake and for the detection of a reducing environment. Methods of detection of bio- molecules such as metabolites, activity of enzymes and proteases and methods for determining a sequence within a peptide of protein cleaved by specific enzymes are described. Also a method of determining the cysteine and derivatives thereof concentration in a cell or tissue sample is described. Precursor molecules of D-luciferin according to the invention are advantageous as they are small and travel easily around live systems and allow tissue cells or organs to be targeted specifically. Further, the methods and screening assays described allow the simultaneous study of multiple biological processes described above in one experiment only.