2-(5-methoxypyridin-3-yl)-10-[3-(trifluoromethyl)phenyl]-9H-pyrido[3,2-c][1,5]naphthyridin-9-ol

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2-(5-methoxypyridin-3-yl)-10-[3-(trifluoromethyl)phenyl]-9H-pyrido[3,2-c][1,5]naphthyridin-9-ol
• 化学式: C₂₄H₁₇F₃N₄O₂
• 分子量: 450.4
• InChiKey: SHGWBRYGBKDQAM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  33
• 可旋转键数：
  3
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  71.4
• 氢给体数：
  1
• 氢受体数：
  9

文献信息

• PYRIDONAPHTHYRIDINE PI3K/MTOR DUAL INHIBITORS AND PREPARATION AND USE THEREOF
  申请人：Xuanzhu Pharma Co., Ltd.

  公开号：EP2719697A1

  公开（公告）日：2014-04-16

  The present invention relates to a pyridonaphthyridine compound as represented by general formula (I), which has a dual PI3K and mTOR inhibition effect, and its pharmaceutically acceptable salt, stereoisomer and deuteride thereof, wherein R1, R2, R3, R4, R5, R6, R7 and X are as defined in the specification; the present invention also relates to a method for preparing said compound, a pharmaceutical composition and a pharmaceutical formulation containing said compound, and uses of said compound in treating and/or preventing a proliferative disease and in the manufacture of a medicament for treating and/or preventing a proliferative disease.

  本发明涉及通式(I)所代表的具有 PI3K 和 mTOR 双重抑制作用的吡啶萘啶化合物及其药学上可接受的盐、立体异构体和氘代物，其中 R1、R2、R3、R4、R5、R6、R7 和 X 如说明书中所定义；本发明还涉及制备所述化合物的方法、含有所述化合物的药物组合物和药物制剂，以及所述化合物在治疗和/或预防增殖性疾病和制造治疗和/或预防增殖性疾病的药物中的用途。