[anilino-(7-benzyl-6,8-dihydro-5H-imidazo[1,5-a]pyrazin-3-yl)methyl]phosphonic acid

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: [anilino-(7-benzyl-6,8-dihydro-5H-imidazo[1,5-a]pyrazin-3-yl)methyl]phosphonic acid
• 化学式: C₂₀H₂₃N₄O₃P
• 分子量: 398.4
• InChiKey: OGDTYKSIVVEIHY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.4
• 重原子数：
  28
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  90.6
• 氢给体数：
  3
• 氢受体数：
  6

文献信息

• [EN] TETRAHYDROIMDIDAZOPYRAZINE DERIVATIVES AS CGRP RECEPTOR ANTAGONISTS<br/>[FR] DÉRIVÉS DE TÉTRAHYDROIMDIDAZOPYRAZINE À UTILISER EN TANT QU'ANTAGONISTES DU RÉCEPTEUR CGRP
  申请人：BRISTOL MYERS SQUIBB CO

  公开号：WO2014062548A1

  公开（公告）日：2014-04-24

  The disclosure generally relates to the novel compounds of formula I, including pharmaceutically acceptable salts, which are CGRP receptor antagonists. The disclosure also relates to pharmaceutical compositions and methods for using the compounds in the treatment of CGRP related disorders including migraine and other headaches, neurogenic vasodilation, neurogenic inflammation, thermal injury, circulatory shock, flushing associated with menopause, airway inflammatory diseases such as asthma, and chronic obstructive pulmonary disease (COPD). [INSERT CHEMICAL STRUCTURE HERE] I

  该公开涉及公式I的新化合物，包括药用盐，这些化合物是CGRP受体拮抗剂。该公开还涉及制药组合物和使用这些化合物治疗与CGRP相关疾病的方法，包括偏头痛和其他头痛、神经源性血管扩张、神经源性炎症、热损伤、循环休克、与绝经期相关的潮红、哮喘等气道炎症疾病，以及慢性阻塞性肺病（COPD）。
• TETRAHYDROIMDIDAZOPYRAZINE DERIVATIVES AS CGRP RECEPTOR ANTAGONISTS
  申请人：Bristol-Myers Squibb Company

  公开号：EP2920173A1

  公开（公告）日：2015-09-23
• SUBSTITUTED IMIDAZO[1,5-a]PYRAZINES AS CGRP RECEPTOR ANTAGONISTS
  申请人：Bristol-Myers Squibb Company

  公开号：US20180030057A1

  公开（公告）日：2018-02-01

  The disclosure generally relates to the novel compounds of formula I, including pharmaceutically acceptable salts, which arc CGRP-receptor antagonists. The disclosure also relates to pharmaceutical compositions and methods for using the compounds in the treatment of CGRP related disorders including migraine headaches, neurogenic vasodilation, neurogenic inflammation, thermal injury, circulatory shock, flushing associated with menopause, airway inflammatory diseases such as asthma, and chronic obstructive pulmonary disease (COPD).