Di-(3,5-di-tert-butyl-4-hydroxy-benzyl)methylamin | 4932-15-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Di-(3,5-di-tert-butyl-4-hydroxy-benzyl)methylamin
• 英文别名: 4-{[N-methyl-N-(4-hydroxy-3,5-bis(1,1-dimethylethyl)benzyl)amino]methyl}-2,6-bis(1,1-dimethylethyl)phenol；N,N-di-[3,5-di-t-butyl-4-hydroxybenzyl]methylamine；FA 15 (antioxidant)；2,6-ditert-butyl-4-[[(3,5-ditert-butyl-4-hydroxyphenyl)methyl-methylamino]methyl]phenol
• CAS: 4932-15-4
• 化学式: C₃₁H₄₉NO₂
• 分子量: 467.736
• InChiKey: UCQIYQJHXVLJTD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.2
• 重原子数：
  34
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.61
• 拓扑面积：
  43.7
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• Processes for the preparation of y-methacryloxypropylsilane compounds
  申请人：Tonen Corporation

  公开号：EP0472438A1

  公开（公告）日：1992-02-26

  There are provided processes for the preparation of γ-methacryloxypropylsilane compounds which comprise carrying out the reaction of allyl methacrylate with a hydrosilane compound in the presence of a platinum catalyst, while allowing at least one of a hindered phenol compound and an aromatic amine compound to coexist in the reaction system with an alkylamine compound or an amide compound, or with a gas containing molecular oxygen, or with a phenol compound having an aminoalkylene group. By using these processes as provided, gelation of the reaction mixture in the reaction system and during the course of purification thereof by distillation can effectively be avoided, and the desired γ-methacryloxypropylsilane compounds can be obtained in good yield.

  本发明提供了制备γ-甲基丙烯酰氧基丙基硅烷化合物的工艺，包括在铂催化剂存在下进行甲基丙烯酸烯丙酯与氢硅烷化合物的反应，同时允许受阻酚化合物和芳香胺化合物中的至少一种与烷基胺化合物或酰胺化合物，或与含分子氧的气体，或与具有氨基烷基的酚化合物共存于反应体系中。通过使用所提供的这些工艺，可以有效地避免反应混合物在反应体系中和通过蒸馏提纯过程中的凝胶化，并能以良好的收率获得所需的γ-甲基丙烯酰氧基硅烷化合物。
• Method for treating imflammation, ischemia-induced cell damage and muscular dystrophy
  申请人：ELI LILLY AND COMPANY

  公开号：EP0476846A2

  公开（公告）日：1992-03-25

  Provided are methods of treating inflammation, arthritis and muscular dystrophy and preventing ischemia-induced cell damage employing certain phenol and benzamide compounds.

  本发明提供了利用某些苯酚和苯甲酰胺化合物治疗炎症、关节炎和肌肉萎缩症以及预防缺血引起的细胞损伤的方法。
• Method of treating inflammatory bowel disease
  申请人：ELI LILLY AND COMPANY

  公开号：EP0474403A1

  公开（公告）日：1992-03-11

  The present invention provides a method for treating inflammatory bowel disease in mammals utilizing certain phenol and benzamide compounds.

  本发明提供了一种利用某些苯酚和苯甲酰胺化合物治疗哺乳动物炎症性肠病的方法。
• Composition containing certain phenol and benzamide for the treatment of type I diabetes
  申请人：UNIVERSITY OF COLORADO FOUNDATION, INC.

  公开号：EP0500336A1

  公开（公告）日：1992-08-26

  Provided is a method for treating Type I diabetes in mammals, and novel formulations suitable therefor, employing certain phenol and benzamide compounds.

  本发明提供了一种利用某些苯酚和苯甲酰胺化合物治疗哺乳动物 I 型糖尿病的方法，以及适用于该方法的新型制剂。
• Method for treating inflammation, ischemia-induced cell damage and muscular dystrophy
  申请人：ELI LILLY AND COMPANY

  公开号：EP0680755A1

  公开（公告）日：1995-11-08

  Provided are methods of treating inflammation, arthritis and muscular dystrophy and preventing ischemia-induced cell damage employing certain phenol and benzamide compounds.

  本发明提供了利用某些苯酚和苯甲酰胺化合物治疗炎症、关节炎和肌肉萎缩症以及预防缺血引起的细胞损伤的方法。