5-Benzyl-3-ethoxy-5-methyl-1,3-thiazolidine-2,4-dione

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 英文名称: 5-Benzyl-3-ethoxy-5-methyl-1,3-thiazolidine-2,4-dione
• 英文别名: 5-benzyl-3-ethoxy-5-methyl-1,3-thiazolidine-2,4-dione
• 化学式: C₁₃H₁₅NO₃S
• 分子量: 265.33
• InChiKey: YNTVBVLEOJFYAX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  71.9
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• COMBINATION OF AN ANTI-CANCER AGENT SUCH AS A TYROSINEKINASE INHIBITOR AND A STAT5 ANTAGONIST, PREFERABLY A THIAZOLIDINEDIONE, FOR ELIMINATING HEMATOLOGIC CANCER STEM CELLS IN VIVO AND FOR PREVENTING HEMATOLOGIC CANCER RELAPSE
  申请人：Commissariat à l'Énergie Atomique et aux Énergies Alternatives

  公开号：EP2914250A1

  公开（公告）日：2015-09-09
• [EN] COMBINATION OF AN ANTI-CANCER AGENT SUCH AS A TYROSINEKINASE INHIBITOR AND A STAT5 ANTAGONIST, PREFERABLY A THIAZOLIDINEDIONE, FOR ELIMINATING HEMATOLOGIC CANCER STEM CELLS IN VIVO AND FOR PREVENTING HEMATOLOGIC CANCER RELAPSE<br/>[FR] ASSOCIATION D'UN AGENT ANTICANCÉREUX TEL QU'UN INHIBITEUR DE LA TYROSINE KINASE ET UN ANTAGONISTE DE STAT5, DE PRÉFÉRENCE UN THIAZOLIDINEDIONE, POUR ÉLIMINER LES CELLULES SOUCHES DES CANCERS HÉMATOLOGIQUES IN VIVO ET POUR PRÉVENIR DES RECHUTES DES CANCERS HÉMATOLOGIQUES
  申请人：COMMISSARIAT ENERGIE ATOMIQUE

  公开号：WO2014068397A1

  公开（公告）日：2014-05-08

  Provided are methods for eliminating hematologic cancer stem cells in vivo, and thus preventing cancer relapse. The methods comprise a Signal Transducer and Activator of Transcription 5 (STAT5) antagonist (e.g., a PPARy agonist) after the patient has had ana initial course of treatment with an anti-cancer agent (e.g., a TKI), to eliminate residual cancer stem cells which cause relapse.