5-[3-(azepan-1-yl)prop-1-ynyl]-N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-3-[ethyl-[4-[2-methoxyethyl(methyl)amino]cyclohexyl]amino]-2-methylbenzamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 5-[3-(azepan-1-yl)prop-1-ynyl]-N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-3-[ethyl-[4-[2-methoxyethyl(methyl)amino]cyclohexyl]amino]-2-methylbenzamide
• 化学式: C₃₇H₅₅N₅O₃
• 分子量: 617.9
• InChiKey: XXMFWUINLLZROZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  45
• 可旋转键数：
  12
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  77.2
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• [EN] SUBSTITUTED BENZENE COMPOUNDS<br/>[FR] COMPOSÉS DE BENZÈNE SUBSTITUÉ
  申请人：EPIZYME INC

  公开号：WO2014062733A2

  公开（公告）日：2014-04-24

  The present invention relates to substituted benzene compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating cancer by administering these compounds and pharmaceutical compositions to subjects in need thereof. The present invention also relates to the use of such compounds for research or other non-therapeutic purposes.
• [EN] METHOD OF TREATING CANCER<br/>[FR] MÉTHODE DE TRAITEMENT DU CANCER
  申请人：EPIZYME INC

  公开号：WO2015058125A1

  公开（公告）日：2015-04-23

  The present invention relates to methods of treating cancer by administering an EZH2 inhibitor or a pharmaceutical composition thereof to the subject in need thereof.
• [EN] EZH2 INHIBITORS FOR TREATING LYMPHOMA<br/>[FR] INHIBITEURS DE EZH2 UTILISABLES À DES FINS DE TRAITEMENT DU LYMPHOME
  申请人：EPIZYME INC

  公开号：WO2015195848A1

  公开（公告）日：2015-12-23

  he present invention relates to methods of treating cancer by administering an EZH2 inhibitor or a pharmaceutical composition thereof to the subject in need thereof. The present claims define methods for treating specific subtypes of non-Hodgkin's lymphoma comprising the administration to a subject of EZH2 inhibitors. Preferred EZH2 inhibitors include tazemetostat (EPZ-6438 E7438) and other compounds. Dosage amounts and regimes are also defined.
• [EN] EZH2 INHIBITORS FOR TREATING LYMPHOMA<br/>[FR] INHIBITEURS D'EZH2 POUR TRAITER LE LYMPHOME
  申请人：EPIZYME INC

  公开号：WO2016201328A1

  公开（公告）日：2016-12-15

  The present disclosure relates to compositions comprising inhibitors of human histone methyltransferase EZH2 and one or more other therapeutic agents, particularly anticancer agents such as prednisone, and methods of combination therapy for administering to subjects in need thereof for the treatment of cancer.