1-Ethyl-3-methyl-imidazolidin-2-thion | 66448-79-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 英文名称: 1-Ethyl-3-methyl-imidazolidin-2-thion
• 英文别名: 1-Ethyl-3-methylimidazolidine-2-thione
• CAS: 66448-79-1
• 化学式: C₆H₁₂N₂S
• 分子量: 144.241
• InChiKey: SJWWBYYFGAVMGX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  9
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  38.6
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1-Ethyl-3-methyl-imidazolidin-2-thion 、 cadmium(II) chloride 以 甲醇 、 水 、 乙腈 为溶剂， 生成 [(N-ethyl-N'-methylimidazolidine-2-thione)2 cadmium(II) (chloride)2]
  参考文献：
  名称：

  新型咪唑烷-2-硫酮及其衍生物的氯化镉配合物：X射线结构，固态和溶液NMR和抗菌活性研究

  摘要：

  摘要咪唑烷-2-硫酮（Imt），1,3-二氮杂环丁烷-2-硫酮（Diaz）和1,3-二氮杂环庚烷-2-硫酮（Diap）与氯化镉（II）在甲醇中的反应导致形成2：1复合体。除了X射线结构外，固态和溶液NMR都证实环外硫原子在所有情况下都是供体。从固态NMR光谱计算出镉屏蔽张量和各向异性。两种配合物（NMeImt）2CdCl2和（NEtImt）2CdCl2的X射线结构揭示了扭曲的四面体几何形状。抗菌活性研究表明，与相应的Zn（II）复合物相比，Cd（Diap）2Cl2复合物表现出显着的抗菌活性。

  DOI：

  10.1016/j.poly.2006.12.022
• 作为产物：
  描述：

  1-Ethyl-2-methylmercapto-Δ²-imidazolin 以100%的产率得到
  参考文献：
  名称：

  ASSEF G.; KISTER J.; METZGER J., BULL. SOC. CHIM. FRANCE, 1979, PART. 2, NO 3-4, 165-176

  摘要：

  DOI：

文献信息

• Cadmium cyanide complexes with heterocyclic thiones: Solid state and solution NMR studies
  作者：Anvarhusein A. Isab、Mohammed I.M. Wazeer、Waqar Ashraf

  DOI：10.1016/j.saa.2008.09.007

  日期：2009.2

  Cadmium(II)cyanide complexes of various thiones (imidazolidine-2-thione, diazinane-2-thione and their derivatives) have been prepared and characterized by elemental analysis, IR and solid as well as solution NMR spectroscopy. It appears from the IR data that all complexes are non-ionic [(>CS)2Cd(CN)2]. An upfield shift in the 13C NMR and downfield shifts in the 1H NMR are consistent with the sulfur

  已制备了各种硫酮（咪唑烷-2-硫酮，二氮杂烷-2-硫酮及其衍生物）的氰化镉（II）配合物，并通过元素分析，IR和固体以及溶液NMR光谱进行了表征。从IR数据看来，所有络合物都是非离子的[（> C S）2 Cd（CN）2 ]。13 C NMR中的高场位移和1 H NMR中的低场位移与硫与镉（II）的配位相一致。固体113 Cd NMR数据显示某些配合物中存在不同的配位数。
• Efficient synthesis of 2-methylaminothiazolines via Mitsunobu reaction of N-(2-hydroxyethyl)-N′-methyl-thioureas
  作者：Taek Hyeon Kim、Mi-Hyun Cha

  DOI：10.1016/s0040-4039(99)00457-8

  日期：1999.4

  2-Methylaminothiazolines 3 were synthesized selectively from N-(2-hydroxyethyl)-thioureas 2 by the intramolecular Mitsunobu reaction.

  通过分子内的Mitsunobu反应从N-（2-羟乙基）-硫脲2选择性地合成2-甲基氨基噻唑啉3。
• c-MET MODULATORS AND METHOD OF USE
  申请人：BANNEN CANNE LYNNE

  公开号：US20070244116A1

  公开（公告）日：2007-10-18

  The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. More specifically, the invention provides quinazolines and quinolines which inhibit, regulate, and/or modulate kinase receptor, particularly c-Met, KDF, c-Kit, flt-3 and flt-4, signal transduction pathways related to the changes in cellular activities as mentioned above, compositions which contain these compounds, and methods of using them to treat kinase-dependent diseases and conditions. The present invention also provides methods for making compounds as mentioned above, and compositions which contain these compounds.

  本发明提供了用于调节蛋白激酶酶活性，以调节细胞活动，如增殖、分化、程序性细胞死亡、迁移和化学侵袭的化合物。更具体地，本发明提供了喹唑啉和喹啉，这些化合物抑制、调节和/或调节激酶受体，特别是c-Met、KDF、c-Kit、flt-3和flt-4，与上述细胞活动变化相关的信号转导途径，包含这些化合物的组合物，以及使用它们治疗激酶依赖性疾病和病况的方法。本发明还提供制备上述化合物的方法和包含这些化合物的组合物。
• C-MET MODULATORS AND METHOD OF USE
  申请人：Bannen Canne Lynne

  公开号：US20070225307A1

  公开（公告）日：2007-09-27

  The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. More specifically, the invention provides quinazolines and quinolines which inhibit, regulate, and/or modulate kinase receptor, particularly c-Met, KDF, c-Kit, flt-3 and flt-4, signal transduction pathways related to the changes in cellular activities as mentioned above, compositions which contain these compounds, and methods of using them to treat kinase-dependent diseases and conditions. The present invention also provides methods for making compounds as mentioned above, and compositions which contain these compounds.

  本发明提供了用于调节蛋白激酶酶活性以调节细胞活动（如增殖、分化、程序性细胞死亡、迁移和化学入侵）的化合物。更具体地，该发明提供了喹唑啉和喹啉，它们能够抑制、调节和/或调节激酶受体，特别是c-Met、KDF、c-Kit、flt-3和flt-4，与上述细胞活动变化相关的信号转导途径，包含这些化合物的组合物，以及使用它们治疗激酶依赖性疾病和病况的方法。本发明还提供了制备上述化合物和包含这些化合物的组合物的方法。
• c-Met modulators and methods of use
  申请人：Bannen Canne Lynne

  公开号：US20070054928A1

  公开（公告）日：2007-03-08

  The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. More specifically, the invention provides quinazolines and quinolines which inhibit, regulate and/or modulate kinase receptor, particularly c-Met, KDR, c-Kit, flt-3 and flt-4, signal transduction pathways related to the changes in cellular activities as mentioned above, compositions which contain these compounds, and methods of using them to treat kinase-dependent diseases and conditions. The present invention also provides methods for making compounds as mentioned above, and compositions which contain these compounds.

  本发明提供了用于调节蛋白激酶酶活性以调节细胞活动（如增殖、分化、程序性细胞死亡、迁移和化学入侵）的化合物。更具体地，本发明提供了能够抑制、调节和/或调节激酶受体，特别是c-Met、KDR、c-Kit、flt-3和flt-4，与上述细胞活动变化相关的信号转导途径的喹唑啉和喹啉，以及包含这些化合物的组合物和使用它们治疗激酶依赖性疾病和病况的方法。本发明还提供了制备上述化合物和包含这些化合物的组合物的方法。