4-[4-amino-1-[1-[2-(trifluoromethyl)prop-2-enoyl]pyrrolidin-2-yl]imidazo[1,5-a]pyrazin-4-ium-3-yl]-N-pyridin-2-ylbenzamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-[4-amino-1-[1-[2-(trifluoromethyl)prop-2-enoyl]pyrrolidin-2-yl]imidazo[1,5-a]pyrazin-4-ium-3-yl]-N-pyridin-2-ylbenzamide
• 化学式: C26H23F3N7O2+
• 分子量: 522.5
• InChiKey: VNJORYHOUPHDBX-UHFFFAOYSA-O

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  38
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  113
• 氢给体数：
  2
• 氢受体数：
  9

文献信息

• 4-IMIDAZOPYRIDAZIN-1-YL-BENZAMIDES AND 4-IMIDAZOTRIAZIN-1-YL-BENZAMIDES AS BTK INHIBITORS
  申请人：Merck Sharp & Dohme B.V.

  公开号：US20160159810A1

  公开（公告）日：2016-06-09

  The present invention relates to 6-5 membered fused pyridine ring compounds according to Formula (I) or a pharmaceutically acceptable salt thereof or to pharmaceutical compositions comprising these compounds and to their use in therapy. In particular, the present invention relates to the use of 6-5 membered fused pyridine ring compounds according to Formula (I) in the treatment of Bruton's Tyrosine Kinase (Btk) mediated disorders.

  本发明涉及公式(I)所示的6-5成员融合吡啶环化合物，或其药学上可接受的盐，以及包含这些化合物的制药组合物及其在治疗中的用途。特别地，本发明涉及使用公式(I)所示的6-5成员融合吡啶环化合物治疗布鲁顿酪氨酸激酶（Btk）介导的疾病。
• (S)-4-(8-AMINO-3-(1-(BUT-2-YNOYL)PYRROLIDIN-2-YL)IMIDAZO[1,5-A]PYRAZIN-1-YL)-2-METHOXY-N-(PYRIDIN-2-YL)BENZAMIDE AS BTK-INHIBITOR
  申请人：Merck Sharp & Dohme B.V.

  公开号：EP3495368A1

  公开（公告）日：2019-06-12

  The present invention relates to 6-5 membered fused pyridine ring compounds according to formula I or a pharmaceutically acceptable salt thereof or to pharmaceutical compositions comprising these compounds and to their use in therapy. In particular, the present invention relates to the use of 6-5 membered fused pyridine ring compounds according to formula I in the treatment of Bruton's Tyrosine Kinase (Btk) mediated disorders.

  本发明涉及符合式 I 的 6-5 分子融合吡啶环化合物 或其药学上可接受的盐，或包含这些化合物的药物组合物，以及它们在治疗中的用途。特别是，本发明涉及根据式 I 的 6-5 位融合吡啶环化合物在治疗布鲁顿酪氨酸激酶（Btk）介导的疾病中的用途。
• 4-IMIDAZOPYRIDAZIN-1-YL-BENZAMIDES AND 4-IMIDAZOTRIAZIN-1-YL-BENZAMIDES AS BTK-INHIBITORS
  申请人：Merck Sharp & Dohme B.V.

  公开号：EP3689878A1

  公开（公告）日：2020-08-05

  The present invention relates to 6-5 membered fused pyridine ring compounds according to formula I or a pharmaceutically acceptable salt thereof or to pharmaceutical compositions comprising these compounds and to their use in therapy. In particular, the present invention relates to the use of 6-5 membered fused pyridine ring compounds according to formula I in the treatment of Bruton's Tyrosine Kinase (Btk) mediated disorders.

  本发明涉及符合式 I 的 6-5 分子融合吡啶环化合物 或其药学上可接受的盐，或包含这些化合物的药物组合物，以及它们在治疗中的用途。特别是，本发明涉及根据式 I 的 6-5 位融合吡啶环化合物在治疗布鲁顿酪氨酸激酶（Btk）介导的疾病中的用途。
• 4-imidazopyridazin-1-yl-benzamides as BTK inhibitors
  申请人：Merck Sharp & Dohme B.V.

  公开号：US10239883B2

  公开（公告）日：2019-03-26

  The present invention relates to 6-5 membered fused pyridine ring compounds according to Formula (I) or a pharmaceutically acceptable salt thereof or to pharmaceutical compositions comprising these compounds and to their use in therapy. In particular, the present invention relates to the use of 6-5 membered fused pyridine ring compounds according to Formula (I) in the treatment of Bruton's Tyrosine Kinase (Btk) mediated disorders.

  本发明涉及符合式 (I) 的 6-5 位融合吡啶环化合物 或其药学上可接受的盐，或包含这些化合物的药物组合物，以及它们在治疗中的用途。特别是，本发明涉及根据式（I）的 6-5 位融合吡啶环化合物在治疗布鲁顿酪氨酸激酶（Btk）介导的疾病中的用途。
• 4-imidazopyridazin-1-yl-benzamides as Btk inhibitors
  申请人：Merck Sharp & Dohme B.V.

  公开号：US10934296B2

  公开（公告）日：2021-03-02

  The present invention relates to 6-5 membered fused pyridine ring compounds according to Formula (I) or a pharmaceutically acceptable salt thereof or to pharmaceutical compositions comprising these compounds and to their use in therapy. In particular, the present invention relates to the use of 6-5 membered fused pyridine ring compounds according to Formula (I) in the treatment of Bruton's Tyrosine Kinase (Btk) mediated disorders.

  本发明涉及符合式 (I) 的 6-5 位融合吡啶环化合物 或其药学上可接受的盐，或包含这些化合物的药物组合物，以及它们在治疗中的用途。特别是，本发明涉及根据式（I）的 6-5 位融合吡啶环化合物在治疗布鲁顿酪氨酸激酶（Btk）介导的疾病中的用途。