Tert-butyl 4-[[5-chloro-2-methyl-3-[(6-methylpyridine-3-carbonyl)amino]phenyl]methyl]-2-methylpiperazine-1-carboxylate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Tert-butyl 4-[[5-chloro-2-methyl-3-[(6-methylpyridine-3-carbonyl)amino]phenyl]methyl]-2-methylpiperazine-1-carboxylate
• 英文别名: tert-butyl 4-[[5-chloro-2-methyl-3-[(6-methylpyridine-3-carbonyl)amino]phenyl]methyl]-2-methylpiperazine-1-carboxylate
• 化学式: C₂₅H₃₃ClN₄O₃
• 分子量: 473.0
• InChiKey: UOIGNCCAYVCSKO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  33
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.48
• 拓扑面积：
  74.8
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• [EN] NOVEL COMPOUNDS<br/>[FR] NOUVEAUX COMPOSÉS
  申请人：GLAXOSMITHKLINE IP DEV LTD

  公开号：WO2015180613A1

  公开（公告）日：2015-12-03

  The present invention relates to novel retinoid-related orphan receptor gamma (RORγ) modulators and their use in the treatment of diseases mediated by RORγ.

  本发明涉及新型视黄醇相关孤儿受体γ（RORγ）调节剂及其在治疗由RORγ介导的疾病中的应用。
• MODULATORS OF THE RETINOID-RELATED ORPHAN RECEPTOR GAMMA (ROR-GAMMA) FOR USE IN THE TREATMENT OF AUTOIMMUNE AND INFLAMMATORY DISEASES
  申请人：GLAXO GROUP LIMITED

  公开号：US20150299121A1

  公开（公告）日：2015-10-22

  The present invention relates to novel retinoid-related orphan receptor gamma (RORγ) modulators and their use in the treatment of diseases mediated by RORγ.

  本发明涉及新型视黄醇相关孤儿受体γ（RORγ）调节剂及其在治疗由RORγ介导的疾病中的应用。
• Modulators of the retinoid-related orphan receptor gamma (ROR-gamma) for use in the treatment of autoimmune and inflammatory diseases
  申请人：Glaxo Group Limited

  公开号：US10005731B2

  公开（公告）日：2018-06-26

  The present invention relates to novel retinoid-related orphan receptor gamma (RORγ) modulators and their use in the treatment of diseases mediated by RORγ.

  本发明涉及新型视黄醇相关孤儿受体γ（RORγ）调节剂及其在治疗由 RORγ 介导的疾病中的用途。
• NOVEL COMPOUNDS
  申请人：GlaxoSmithKline Intellectual Property Development Limited

  公开号：EP3148985A1

  公开（公告）日：2017-04-05
• PIPERAZINE DERIVATIVES AS ROR-GAMMA MODULATORS
  申请人：GlaxoSmithKline Intellectual Property Development Limited

  公开号：EP3148987B1

  公开（公告）日：2019-01-02