2-[(Aminodiazenyl)methyl]aniline

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-[(Aminodiazenyl)methyl]aniline
• 英文别名: 2-[(aminodiazenyl)methyl]aniline
• 化学式: C₇H₁₀N₄
• 分子量: 150.18
• InChiKey: PMBSEBLBZMNWMK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  76.8
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• [EN] AZOLOPYRIMIDINE FOR THE TREATMENT OF CANCER-RELATED DISORDERS<br/>[FR] AZOLOPYRIMIDINE POUR LE TRAITEMENT DE TROUBLES LIÉS AU CANCER
  申请人：ARCUS BIOSCIENCES INC

  公开号：WO2018136700A1

  公开（公告）日：2018-07-26

  Compound that is an inhibitor of at least one of the A2A and A2B adenosine receptors, and compositions containing the compound and methods for synthesizing the compound, are described herein. The use of such compound and compositions for the treatment of a diverse array of diseases, disorders, and conditions, including cancer- and immune-related disorders that are mediated, at least in part, by the adenosine A2A receptor and/or the adenosine A2B receptor.

  本文描述了一种至少抑制A2A和A2B腺苷受体中至少一种的化合物，以及含有该化合物的组合物和合成该化合物的方法。利用这种化合物和组合物治疗各种疾病、紊乱和病况，包括至少部分由腺苷A2A受体和/或腺苷A2B受体介导的癌症和免疫相关紊乱。
• Azolopyrimidine for the treatment of cancer-related disorders
  申请人：ARCUS BIOSCIENCES, INC.

  公开号：US11072597B2

  公开（公告）日：2021-07-27

  Compound that is an inhibitor of at least one of the A2A and A2B adenosine receptors, and compositions containing the compound and methods for synthesizing the compound, are described herein. The use of such compound and compositions for the treatment of a diverse array of diseases, disorders, and conditions, including cancer- and immune-related disorders that are mediated, at least in part, by the adenosine A2A receptor and/or the adenosine A2B receptor.

  本文描述了作为 A2A 和 A2B 腺苷受体中至少一种受体抑制剂的化合物，以及含有该化合物的组合物和合成该化合物的方法。这些化合物和组合物可用于治疗多种疾病、失调和病症，包括至少部分由腺苷 A2A 受体和/或腺苷 A2B 受体介导的癌症和免疫相关疾病。
• PROCÉDÉ DE PRÉPARATION DE COMPOSÉS AZOTÉS
  申请人：Commissariat à l'Énergie Atomique et aux Énergies Alternatives

  公开号：EP2855427B1

  公开（公告）日：2017-04-19
• AMINE-CONTAINING LIPIDOIDS AND USES THEREOF
  申请人：Massachusetts Institute of Technology

  公开号：US20140161830A1

  公开（公告）日：2014-06-12

  Provided herein are lipidoids that may be prepared from the conjugate addition of alkylamines to acrylates. In some embodiments, provided lipidoids are biodegradable and may be used in a variety of drug delivery systems. Given the amino moiety of the lipidoids, they are well-suited for the delivery of polynucleotides, in addition to other agents. Nanoparticles containing the inventive lipidoids and polynucleotides have been prepared and have been shown to be effective in delivering siRNA.
• AZOLOPYRIMIDINE FOR THE TREATMENT OF CANCER-RELATED DISORDERS
  申请人：ARCUS BIOSCIENCES, INC.

  公开号：US20220144808A1

  公开（公告）日：2022-05-12

  Compound that is an inhibitor of at least one of the A 2A and A 2B adenosine receptors, and compositions containing the compound and methods for synthesizing the compound, are described herein. The use of such compound and compositions for the treatment of a diverse array of diseases, disorders, and conditions, including cancer- and immune-related disorders that are mediated, at least in part, by the adenosine A 2A receptor and/or the adenosine A 2B receptor.