1-(2-Aminoethyl)pyrrolidin-3-amine;dihydrochloride

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: 1-(2-Aminoethyl)pyrrolidin-3-amine;dihydrochloride
• 英文别名: 1-(2-aminoethyl)pyrrolidin-3-amine;dihydrochloride
• 化学式: C6H17Cl2N3
• 分子量: 202.12
• InChiKey: FQIHYWDRPDXBTB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.18
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  55.3
• 氢给体数：
  4
• 氢受体数：
  3

文献信息

• Substituted fused imidazole derivatives, pharmaceutical compositions, and methods of use thereof
  申请人：vTv Therapeutics LLC

  公开号：US10030011B2

  公开（公告）日：2018-07-24

  Substituted fused imidazole derivatives, methods of their preparation, pharmaceutical compositions comprising a substituted fused imidazole derivative, and methods of use in treating inflammation are provided. The substituted fused imidazole derivatives may control the activity or the amount or both the activity and the amount of heme-oxygenase.

  本研究提供了取代的融合咪唑衍生物、其制备方法、包含取代的融合咪唑衍生物的药物组合物以及用于治疗炎症的方法。取代的融合咪唑衍生物可控制血红素加氧酶的活性或数量，或同时控制活性和数量。
• Substituted Fused Imidazole Derivatives, Pharmaceutical Compositions, and Methods of Use Thereof
  申请人：vTv Therapeutics LLC

  公开号：US20190194181A1

  公开（公告）日：2019-06-27

  Substituted fused imidazole derivatives, methods of their preparation, pharmaceutical compositions comprising a substituted fused imidazole derivative, and methods of use in treating conditions or diseases of the eye are provided. The substituted fused imidazole derivatives may control the activity or the amount or both the activity and the amount of heme-oxygenase.
• US8759535B2
  申请人：——

  公开号：US8759535B2

  公开（公告）日：2014-06-24