6-Chloro-3-(4-methoxyphenyl)sulfanylpyridine-2-carboxylic acid

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: 6-Chloro-3-(4-methoxyphenyl)sulfanylpyridine-2-carboxylic acid
• 英文别名: 6-chloro-3-(4-methoxyphenyl)sulfanylpyridine-2-carboxylic acid
• 化学式: C₁₃H₁₀ClNO₃S
• 分子量: 295.74
• InChiKey: FHFUUTGJWRDWER-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  84.7
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• NOVEL 2-PYRIDINECARBOXAMIDE DERIVATIVES, COMPOSITIONS CONTAINING SUCH COMPOUNDS, AND METHODS OF TREATMENT
  申请人：Merck Sharp & Dohme Corp.

  公开号：EP2931718A1

  公开（公告）日：2015-10-21
• [EN] NOVEL 2-PYRIDINECARBOXAMIDE DERIVATIVES, COMPOSITIONS CONTAINING SUCH COMPOUNDS, AND METHODS OF TREATMENT<br/>[FR] NOUVEAUX DÉRIVÉS DE PYRIDINE -2-CARBOXAMIDE, COMPOSITIONS CONTENANT DE TELS COMPOSÉS ET MÉTHODES DE TRAITEMENT ASSOCIÉES
  申请人：MERCK SHARP & DOHME

  公开号：WO2014099584A1

  公开（公告）日：2014-06-26

  Novel pyridine-2-carboxamide derivatives of formula I and pharmaceutically acceptable salts thereof are disclosed as useful for treating or preventing type 2 diabetes and similar conditions. The compounds are effective as glucokinase activating agents. Pharmaceutical compositions and methods of treatment are also included. The present invention relates to novel pyridine-2-carboxamide derivatives and salts thereof which are effective as glucokinase activating agents. Moreover, it relates to compositions containing such compounds, and methods of treatment.