2-(2-Aminoethoxymethyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2-(2-Aminoethoxymethyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylic acid
• 英文别名: 2-(2-aminoethoxymethyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylic acid
• 化学式: C₁₁H₁₆N₂O₅
• 分子量: 256.25
• InChiKey: GIRRCQQJYDKVMD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3.5
• 重原子数：
  18
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  122
• 氢给体数：
  4
• 氢受体数：
  7

文献信息

• A PHARMACEUTICAL COMPOSITION CONTAINING CANDESARTAN CILEXETIL AND AMLODIPINE
  申请人：Adamed sp. z o.o.

  公开号：EP2934488A1

  公开（公告）日：2015-10-28
• [EN] A PHARMACEUTICAL COMPOSITION CONTAINING CANDESARTAN CILEXETIL AND AMLODIPINE<br/>[FR] COMPOSITION PHARMACEUTIQUE CONTENANT DU CANDÉSARTAN CILEXETIL ET DE L'AMLODIPINE
  申请人：ADAMED SP ZOO

  公开号：WO2014097209A1

  公开（公告）日：2014-06-26

  A combination pharmaceutical composition comprising candesartan cilexetil and amiodipine or a pharmaceutically acceptable salt thereof, a process for the preparation of such composition and unit dosage form comprising such a composition. The composition consists of a granulate containing candesartan cilexetil, polyethylene glycol and other excipients, wherein the weight ratio of candesartan cilexetil to polyethylene glycol is in the range from 5: 1 to 2: 1, and extragranular phase of powder blend comprising amiodipine or a pharmaceutically acceptable salt thereof and excipients. The composition is prepared by mixing the granulate prepared by wet granulation and extragranular phase.