[1-(Benzenesulfonyl)pyrrolo[2,3-b]pyridin-5-yl]carbamic acid

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: [1-(Benzenesulfonyl)pyrrolo[2,3-b]pyridin-5-yl]carbamic acid
• 英文别名: [1-(benzenesulfonyl)pyrrolo[2,3-b]pyridin-5-yl]carbamic acid
• 化学式: C₁₄H₁₁N₃O₄S
• 分子量: 317.32
• InChiKey: MWBIOHJBRVJQAC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  110
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR
  申请人：Plexxikon Inc.

  公开号：US20140213554A1

  公开（公告）日：2014-07-31

  Compounds active on c-kit protein kinases or mutant c-kit protein kinases having any mutations are described, as well as methods of making and using such compounds to treat diseases and conditions associated with aberrant activity of the c-kit protein kinases and/or mutant c-kit protein kinases.

  本文介绍了对c-kit蛋白激酶或带有任何突变的突变c-kit蛋白激酶活性的化合物，以及制备和使用这些化合物治疗与c-kit蛋白激酶和/或突变c-kit蛋白激酶的异常活性相关的疾病和病状的方法。
• Compounds and methods for kinase modulation, and indications therefor
  申请人：Plexxikon Inc.

  公开号：US10301280B2

  公开（公告）日：2019-05-28

  Compounds active on c-kit protein kinases or mutant c-kit protein kinases having any mutations are described, as well as methods of making and using such compounds to treat diseases and conditions associated with aberrant activity of the c-kit protein kinases and/or mutant c-kit protein kinases.

  本文描述了对具有任何突变的 c-kit 蛋白激酶或突变 c-kit 蛋白激酶具有活性的化合物，以及制造和使用此类化合物治疗与 c-kit 蛋白激酶和/或突变 c-kit 蛋白激酶活性异常有关的疾病和病症的方法。
• Synthesis, pharmacology and use of new and selective FMS-like tyrosine kinase 3 (FLT3) FLT3 inhibitors
  申请人：UNIVERSITÄT REGENSBURG

  公开号：US11384076B2

  公开（公告）日：2022-07-12

  The present invention relates to small molecule compounds of formula (I) and their use as FLT3 inhibitors for the treatment of various diseases, such as acute myeloid leukemia (AML). The present invention further relates to methods of synthesizing the compounds and methods of treatment.

  本发明涉及式（I）的小分子化合物及其作为FLT3抑制剂用于治疗各种疾病，如急性髓性白血病（AML）。本发明进一步涉及化合物的合成方法和治疗方法。
• SYNTHESIS, PHARMACOLOGY AND USE OF NEW AND SELECTIVE FMS-LIKE TYROSINE KINASE 3 (FLT3) FLT3 INHIBITORS
  申请人：UNIVERSITÄT REGENSBURG

  公开号：US20200190075A1

  公开（公告）日：2020-06-18

  The present invention relates to small molecule compounds of formula (I) and their use as FLT3 inhibitors for the treatment of various diseases, such as acute myeloid leukemia (AML). The present invention further relates to methods of synthesizing the compounds and methods of treatment.
• US9676748B2
  申请人：——

  公开号：US9676748B2

  公开（公告）日：2017-06-13