Ethyl 3-bromo-2-[2-[(2-butoxy-4,6-dimethylpyridin-3-yl)methylamino]ethoxy]-6-methyl-5-methylsulfonyloxybenzoate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Ethyl 3-bromo-2-[2-[(2-butoxy-4,6-dimethylpyridin-3-yl)methylamino]ethoxy]-6-methyl-5-methylsulfonyloxybenzoate
• 英文别名: ethyl 3-bromo-2-[2-[(2-butoxy-4,6-dimethylpyridin-3-yl)methylamino]ethoxy]-6-methyl-5-methylsulfonyloxybenzoate
• 化学式: C₂₅H₃₅BrN₂O₇S
• 分子量: 587.5
• InChiKey: QKSRARTXSSIFES-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  36
• 可旋转键数：
  15
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.52
• 拓扑面积：
  121
• 氢给体数：
  1
• 氢受体数：
  9

文献信息

• ARYL AND HETEROARYL FUSED LACTAMS
  申请人：PFIZER INC.

  公开号：US20150175572A1

  公开（公告）日：2015-06-25

  This invention relates to compounds of general formula (I) in which R 1 , R 2 , U, V, L, M, R 5 , m, X, Y and Z are as defined herein, and the pharmaceutically acceptable salts thereof, to pharmaceutical compositions comprising such compounds and salts, and to methods of using such compounds, salts and compositions for the treatment of abnormal cell growth, including cancer.

  本发明涉及一般式（I）的化合物，其中R1、R2、U、V、L、M、R5、m、X、Y和Z的定义如本文所述，并且其药学上可接受的盐，以及包含这种化合物和盐的制药组合物，以及使用这种化合物、盐和组合物治疗异常细胞生长，包括癌症的方法。
• [EN] ARYL AND HETEROARYL FUSED LACTAMS<br/>[FR] LACTAMES FUSIONNÉS À UN ARYLE ET HÉTÉROARYLE
  申请人：PFIZER

  公开号：WO2014097041A1

  公开（公告）日：2014-06-26

  This invention relates to compounds of general Formula (I) in which R1, R2, U, V, L, M, R5, m, X, Y and Z are as defined herein, and the pharmaceutically acceptable salts thereof, to pharmaceutical compositions comprising such compounds and salts, and to methods of using such compounds, salts and compositions for the treatment of abnormal cell growth, including cancer.