N-(4-bromophenyl)quinoline-2-carboxamide | 586985-01-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(4-bromophenyl)quinoline-2-carboxamide
• CAS: 586985-01-5
• 化学式: C₁₆H₁₁BrN₂O
• 分子量: 327.18
• InChiKey: IKLQMYIBTBSMPW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  42
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  喹哪啶酸 、 4-溴苯胺 在 1-丙基磷酸酐 作用下， 以 甲苯 为溶剂， 反应 24.0h， 以68%的产率得到N-(4-bromophenyl)quinoline-2-carboxamide
  参考文献：
  名称：

  An optimized and scalable synthesis of propylphosphonic anhydride for general use

  摘要：

  Propylphosphonic anhydride (T3P (R)) is an effective coupling and dehydrating agent, which has been used for a large number of chemical transformations. An efficient and versatile synthetic method is described to synthesize propylphosphonic anhydride (T3P (R)) in pure form, in an overall yield of 51% in four steps from commercially available diethyl phosphonate. (C) 2015 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2015.02.126

文献信息

• Copper-catalyzed efficient direct amidation of 2-methylquinolines with amines
  作者：Hao Xie、Yunfeng Liao、Shuqing Chen、Ya Chen、Guo-Jun Deng

  DOI：10.1039/c5ob00915d

  日期：——

  A copper catalyzed efficient procedure for quinoline-2-carboxamides formation via direct amidation of 2-methylquinolines under oxygen is described.

  一种铜催化的高效程序，通过在氧气下直接对2-甲基喹啉进行酰胺化，形成喹啉-2-甲酰胺。
• A convenient synthesis of <i>N</i>-(hetero)arylamides by the oxidative coupling of methylheteroarenes with amines
  作者：Anjali Jaiswal、Preeti、Krishna Nand Singh

  DOI：10.1039/d2ob01106a

  日期：——

  An oxidative amidation of 2-methylpyridines/2-methylbenzimidazole with amines using copper acetate and elemental sulfur in DMSO to afford various N-(hetero)arylamides has been accomplished. Mechanistic studies reveal the intermediacy of N-(pyridin-2-ylmethyl)aniline and confirm the role of DMSO as the oxygen source.

  已经完成了使用乙酸铜和元素硫在 DMSO 中将 2-甲基吡啶/2-甲基苯并咪唑与胺的氧化酰胺化，以提供各种N- (杂)芳基酰胺。机理研究揭示了N- (pyridin-2-ylmethyl)aniline 的中间体，并证实了 DMSO 作为氧源的作用。
• An optimized and scalable synthesis of propylphosphonic anhydride for general use
  作者：Hana Pizova、Pavel Bobal

  DOI：10.1016/j.tetlet.2015.02.126

  日期：2015.4

  Propylphosphonic anhydride (T3P (R)) is an effective coupling and dehydrating agent, which has been used for a large number of chemical transformations. An efficient and versatile synthetic method is described to synthesize propylphosphonic anhydride (T3P (R)) in pure form, in an overall yield of 51% in four steps from commercially available diethyl phosphonate. (C) 2015 Elsevier Ltd. All rights reserved.