1-Amino-2-methylpropan-2-ol;2-[2-(2,6-dichloroanilino)phenyl]acetic acid

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-Amino-2-methylpropan-2-ol;2-[2-(2,6-dichloroanilino)phenyl]acetic acid
• 英文别名: 1-amino-2-methylpropan-2-ol;2-[2-(2,6-dichloroanilino)phenyl]acetic acid
• 化学式: C18H22Cl2N2O3
• 分子量: 385.3
• InChiKey: TWNAUSCFZHTSHC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.08
• 重原子数：
  25
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  95.6
• 氢给体数：
  4
• 氢受体数：
  5

文献信息

• DICLOFENAC COMPOSITION
  申请人：Themis Medicare Limited

  公开号：EP2938325B1

  公开（公告）日：2019-04-10
• DICLOFENAC COMPOSITIONS
  申请人：THEMIS MEDICARE LIMITED

  公开号：US20140187635A1

  公开（公告）日：2014-07-03

  The present invention relates a composition comprising Diclofenac and salts thereof wherein Diclofenac or its salts are present in an amount of 25-200 mg. The composition is suitable for the parenteral administration through intramuscular, intravenous route; also for oral, dermal, subcutaneous, cutaneous, nasal, ocular drops, as rectal suppository, vaginal pessaries, intra-articular, and otic delivery. The invention also provides compositions comprising a combination of Diclofenac and other drugs. The invention further provides a method for preparing said composition.
• [EN] DICLOFENAC COMPOSITION<br/>[FR] COMPOSITION DE DICLOFÉNAC
  申请人：THEMIS MEDICARE LTD

  公开号：WO2014102824A1

  公开（公告）日：2014-07-03

  The present invention relates a composition comprising Diclofenac and salts thereof wherein Diclofenac or its slats are present in an amount of 25 - 200 mg. The composition is suitable for the parenteral administration through intramuscular, intravenous route; also for oral, dermal, subcutaneous, cutaneous, nasal, ocular drops, as rectal suppository, vaginal pessaries, intra-articular, and otic delivery. The invention also provides compositions comprising a combination of Diclofenac and other drugs. The invention further provides a method for preparing said composition.
• [EN] NOVEL INJECTABLE COMPOSITION OF DICLOFENAC SODIUM<br/>[FR] NOUVELLE COMPOSITION INJECTABLE DE DICLOFÉNAC SODIQUE
  申请人：UMEDICA LABORATORIES PVT LTD

  公开号：WO2016170401A1

  公开（公告）日：2016-10-27

  The present invention relates to injectable preparations containing 75 mg to 100 mg of water soluble salts of diclofenac in about 1ml injection solution, wherein the pH of the solution is maintained at 8-9 using alkali. The composition is suitable for parenteral administration through intramuscular, intravenous, subcutaneous, intradeltoid, intragluteal route of administration. More specifically, the injectable preparations comprise 75 mg/ml of diclofenac sodium in a solvent system containing water and two or more solubilizers along with antioxidants and buffering agents. The invention also provides a method of preparing the injectable preparations.
• [EN] AQUEOUS INJECTABLE PREPARATIONS OF DICLOFENAC AND ITS PHARMACEUTICALLY ACCEPTABLE SALTS<br/>[FR] PRÉPARATIONS AQUEUSES POUR INJECTION DE DICLOFÉNAC ET DE SES SELS PHARMACEUTIQUEMENT ACCEPTABLES
  申请人：HETERO HEALTHCARE LTD

  公开号：WO2018142313A1

  公开（公告）日：2018-08-09

  The present invention relates to the stable aqueous injectable formulation comprising of Diclofenac or a pharmaceutically acceptable diclofenac salts suitable for intramuscular, intravenous, subcutaneous, nasal, ocular drops, intra-articular, and otic delivery, which causes significantly less pain at site of injection. The formulations medium comprising of water, along with one or more co-solvent(s)/solubilizer(s), antioxidants, chelating agents, buffers, alkali and stabilizers, which cause significantly less pain at the site of injection. The invention further provides a method for preparing said composition, wherein the dose of the diclofenac or a pharmaceutically acceptable diclofenac salts thereof is less than 75 mg, i.e. from about 18.75 mg to 37.5 mg. The present invention is also directed to methods of treatment or prevention of Prophylaxis of postoperative pain, Sprains, Bursitis and Strains, Tendinitis, Acute gout, Pain and inflammation associated with musculoskeletal and joint disorders, Rheumatoid arthritis and for treatment of inflammation after surgery or during surgical procedures, Dysmenorrhoea, Renal colic, pain control of total hip replacement arthroplasty.