4,5-Bis(trifluoromethyl)-2-methylpyridine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 4,5-Bis(trifluoromethyl)-2-methylpyridine
• 英文别名: 2-methyl-4,5-bis(trifluoromethyl)pyridine
• 化学式: C₈H₅F₆N
• 分子量: 229.12
• InChiKey: FSKCPDOJPROEFU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  15
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  12.9
• 氢给体数：
  0
• 氢受体数：
  7

文献信息

• [EN] PIPERAZINE-SUBSTITUTED 7-METHOXY-[1,2,4]TRIAZOLO[1,5-C]QUINAZOLIN-5-AMINE COMPOUNDS WITH A2A ANTAGONIST PROPERTIES<br/>[FR] COMPOSÉS DE 7-MÉTHOXY-[1,2,4]TRIAZOLO[1,5-C]QUINAZOLINE-5-AMINE À SUBSTITUTION PIPÉRAZINE PRÉSENTANT DES PROPRIÉTÉS D'ANTAGONISTE D'A2A
  申请人：MERCK SHARP & DOHME

  公开号：WO2014101113A1

  公开（公告）日：2014-07-03

  Disclosed are compounds of Formula (A), as defined herein, which have binding activity for an A2A-receptor and are believed to be useful for treatment or management of CNS diseases or conditions which can be treated or managed using compounds which have A2A receptor antagonist activity.

  本公开的是本文所定义的Formula (A)的化合物，它们具有与A2A受体的结合活性，并被认为对于治疗或管理可以使用具有A2A受体拮抗活性的化合物来治疗或管理的中枢神经系统疾病或疾况是有用的。
• [EN] PIPERAZINE-SUBSTITUTED [1,2,4]TRIAZOLO[1,5-C]QUINAZOLIN-5-AMINE COMPOUNDS WITH A2A ANTAGONIST PROPERTIES<br/>[FR] COMPOSÉS [1,2,4]TRIAZOLO[1,5-C]QUINAZOLIN-5-AMINES À SUBSTITUTION PAR PIPÉRAZINE AYANT DES PROPRIÉTÉS D'ANTAGONISTES DU RÉCEPTEUR A2A
  申请人：MERCK SHARP & DOHME

  公开号：WO2014105664A1

  公开（公告）日：2014-07-03

  Disclosed are compounds of Formula A: (structurally represented) where "RG1", "RG2a", "RG4", "RG5", "MG1", "n" and "m" are defined herein which compounds are antagonists of A2A receptor. Disclosed herein also are uses of the compounds described herein as antagonists of the A2a receptor in the potential treatment or prevention of neurological disorders and diseases in which A2A receptors are involved. Disclosed herein also are pharmaceutical compositions comprising these compounds and uses of these pharmaceutical compositions.

  公开的是Formula A的化合物：(结构表示)，其中"RG1"，"RG2a"，"RG4"，"RG5"，"MG1"，"n"和"m"在此处被定义为A2A受体的拮抗剂。本文还公开了所述化合物作为A2a受体拮抗剂在潜在治疗或预防A2A受体参与的神经疾病和疾病中的用途。本文还公开了包含这些化合物的药物组合物以及这些药物组合物的用途。
• PYRIDAZINONE COMPOUND OR ITS SALT, AND HERBICIDE CONTAINING IT
  申请人：ISHIHARA SANGYO KAISHA, LTD.

  公开号：US20200172517A1

  公开（公告）日：2020-06-04

  A novel herbicide having remarkable herbicidal activities against undesired plants is provided. A pyridazinone compound represented by the formula (I) or its salt: wherein X is —O—, —S—, —SO—, —SO 2 — or —N(Y)—; Q is monocyclic aryl which may be substituted by Z, monocyclic heteroaryl which may be substituted by Z or the like; Y is a hydrogen atom or alkyl; Z is halogen, alkyl or the like; R 1 is alkyl, alkenyl or the like; R 2 is a hydrogen atom, alkyl or the like; R 3 is halogen, hydroxy or the like; R 4 is a hydrogen atom, alkyl or the like; and n is an integer of from 0 to 4.

  提供了一种对不受欢迎的植物具有显著除草活性的新型除草剂。一种由以下式（I）或其盐表示的吡啶并酮化合物： 其中X为—O—，—S—，—SO—，—SO2—或—N(Y)—；Q为可以由Z取代的单环芳基，可以由Z取代的单环杂芳基或类似物；Y为氢原子或烷基；Z为卤素，烷基或类似物；R1为烷基，烯烃基或类似物；R2为氢原子，烷基或类似物；R3为卤素，羟基或类似物；R4为氢原子，烷基或类似物；n为0到4的整数。
• PIPERAZINE-SUBSTITUTED [1,2,4]TRIAZOLO[1,5-C]QUINAZOLIN-5-AMINE COMPOUNDS WITH A2A ANTAGONIST PROPERTIES
  申请人：ALI Amjad

  公开号：US20160194330A1

  公开（公告）日：2016-07-07

  Disclosed are compounds of Formula A: (structurally represented) where “RG1”, “RG2a”, “RG4”, “RG5”, “MG1”, “n” and “m” are defined herein which compounds are antagonists of A2A receptor. Disclosed herein also are uses of the compounds described herein as antagonists of the A2a receptor in the potential treatment or prevention of neurological disorders and diseases in which A2A receptors are involved. Disclosed herein also are pharmaceutical compositions comprising these compounds and uses of these pharmaceutical compositions.

  本发明公开了A式化合物，其中“RG1”、“RG2a”、“RG4”、“RG5”、“MG1”、“n”和“m”在此被定义，这些化合物是A2A受体拮抗剂。本发明还公开了上述化合物作为A2A受体拮抗剂在潜在的涉及A2A受体的神经系统疾病的治疗或预防中的用途。本发明还公开了包含这些化合物的制药组合物以及这些制药组合物的用途。
• PYRIDAZINONE-TYPE COMPOUND OR SALT THEREOF, AND HERBICIDE COMPRISING SAME
  申请人：Ishihara Sangyo Kaisha, Ltd.

  公开号：EP3438095A1

  公开（公告）日：2019-02-06

  A novel herbicide having remarkable herbicidal activities against undesired plants is provided. A pyridazinone compound represented by the formula (I) or its salt: wherein X is -O-, -S-, -SO-, -SO2- or -N(Y)-; Q is monocyclic aryl which may be substituted by Z, monocyclic heteroaryl which may be substituted by Z or the like; Y is a hydrogen atom or alkyl; Z is halogen, alkyl or the like; R1 is alkyl, alkenyl or the like; R2 is a hydrogen atom, alkyl or the like; R3 is halogen, hydroxy or the like; R4 is a hydrogen atom, alkyl or the like; and n is an integer of from 0 to 4.

  本研究提供了一种新型除草剂，该除草剂对有害植物具有显著的除草活性。 一种由式（I）或其盐代表的哒嗪酮化合物： 其中X是-O-、-S-、-SO-、-SO2-或-N(Y)-；Q是可被Z取代的单环芳基、可被Z取代的单环杂芳基或类似物；Y是氢原子或烷基；Z是卤素、烷基或类似物；R1是烷基、烯基或类似物；R2是氢原子、烷基或类似物；R3是卤素、羟基或类似物；R4是氢原子、烷基或类似物；n是0至4的整数。