(5S,6R)-6-(4-chlorophenyl)-5-[3-(dimethylamino)propyl]-3,4,6,7,8,9-hexahydrobenzo[7]annulen-5-ol

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (5S,6R)-6-(4-chlorophenyl)-5-[3-(dimethylamino)propyl]-3,4,6,7,8,9-hexahydrobenzo[7]annulen-5-ol
• 化学式: C₂₂H₃₀ClNO
• 分子量: 359.9
• InChiKey: YFVALUTVDLHTIN-FGZHOGPDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  25
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  23.5
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• BENZOCYCLOHEPTANE AND BENZOXEPINE DERIVATIVES
  申请人：Janssen Pharmaceutica NV

  公开号：US20140187557A1

  公开（公告）日：2014-07-03

  The present invention relates to a compound of formula (I) including any stereochemically isomeric form thereof, wherein the substituents are as defined in the specification and the claims; a N-oxide thereof, a pharmaceutically acceptable salt thereof or a solvate thereof; provided that the compound is other than or a pharmaceutically acceptable salt thereof. The claimed compounds are useful for the treatment of a disease, the treatment of which is affected, mediated or facilitated by activating the GHS1A-r receptor. The invention also relates to pharmaceutical compositions thereof and processes for the preparation thereof.