2-(2-propyl)naphtho[1,2-d]thiazole | 1446481-39-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 萘并噻唑类
• 英文名称: 2-(2-propyl)naphtho[1,2-d]thiazole
• 英文别名: 2-Propan-2-ylbenzo[e][1,3]benzothiazole
• CAS: 1446481-39-5
• 化学式: C₁₄H₁₃NS
• 分子量: 227.33
• InChiKey: VHSPOJOWBQQNCV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  41.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-甲硫基-beta-萘并噻唑 、 异丙基氯化镁 在 1,3-丁二烯 、 nickel dichloride 作用下， 以 四氢呋喃 为溶剂， -78.0~50.0 ℃ 、101.33 kPa 条件下， 以81%的产率得到2-(2-propyl)naphtho[1,2-d]thiazole
  参考文献：
  名称：

  Nickel-Catalyzed Coupling of Thiomethyl-Substituted 1,3-Benzothiazoles with Secondary Alkyl Grignard Reagents

  摘要：

  DOI：

  10.1002/chem.201203413

文献信息

• ACETIC ACID AMIDE DERIVATIVE HAVING INHIBITORY ACTIVITY ON ENDOTHELIAL LIPASE
  申请人：Masuda Koji

  公开号：US20110251386A1

  公开（公告）日：2011-10-13

  Disclosed is a compound which is useful as an endothelial lipase inhibitor. A pharmaceutical composition having inhibitory activity on endothelial lipase comprising a compound represented by the formula: its pharmaceutically acceptable salt, or a solvate thereof, wherein Ring A is nitrogen-containing hetero ring, Ring A may be substituted with a substituent other than a group represented by the formula: —C(R 1 R 2 )—C(═O)—NR 3 R 4 and a group represented by the formula: —R 5 , a broken line represents the presence or the absence of a bond, Z is —NR 6 —, ═N—, —O—, or —S—, R 6 is halogen, substituted or unsubstituted alkyl or the like, R 1 and R 2 are each independently hydrogen, halogen, hydroxy, cyano, nitro, carboxy or substituted or unsubstituted alkyl, R 3 is hydrogen or substituted or unsubstituted alkyl, R 4 is hydrogen, substituted or unsubstituted alkyl or the like, R 3 and R 4 taken together with the adjacent nitrogen atom to which they are attached may form a substituted or unsubstituted ring, R 5 is hydrogen, halogen, hydroxy, cyano, nitro, carboxy, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl or the like.

  公开了一种作为内皮酯酶抑制剂有用的化合物。一种具有内皮酯酶抑制活性的药物组合物，包括下式所示的化合物：其药学上可接受的盐或其溶剂合物，其中，环A是含氮杂环，环A可以被除了由下式表示的基团：—C(R1R2)—C(═O)—NR3R4和由下式表示的基团：—R5以外的基团取代，其中，一条虚线表示键的存在或不存在，Z为—NR6—，═N—，—O—或—S—，R6为卤素，取代或未取代的烷基或类似物，R1和R2各自独立地为氢、卤素、羟基、氰基、硝基、羧基或取代或未取代的烷基，R3为氢或取代或未取代的烷基，R4为氢、取代或未取代的烷基或类似物，R3和R4与它们所连接的相邻氮原子一起可以形成取代或未取代的环，R5为氢、卤素、羟基、氰基、硝基、羧基、取代或未取代的烷基、取代或未取代的烯基、取代或未取代的炔基或类似物。
• HETEROCYCLIC DERIVATIVE AND ORGANIC ELECTROLUMINESCENT DEVICE THEREOF
  申请人：Changchun Hyperions Technology Co., Ltd.

  公开号：EP4006025A1

  公开（公告）日：2022-06-01

  Provided are a heterocyclic derivative and an organic electroluminescent device thereof, which relates to the field of organic photoelectric materials. The heterocyclic derivative of Formula I has high electron mobility and great hole blocking performance, and thus the organic electroluminescent device prepared by using the heterocyclic derivative as the electron transport region material, especially the hole blocking material, has low drive voltage and high luminous efficiency. The organic electroluminescent device can also include a hole transport region, and the hole transport region, especially the emissive auxiliary layer, contains the triarylamine compound of Formula II. Since the electron transport region and the hole transport region of the device can effectively balance carriers, which reduces the quenching of excitons and improves the recombination probability of carriers, the device shows low drive voltage and high luminous efficiency.

  本发明提供了一种杂环衍生物及其有机电致发光器件，涉及有机光电材料领域。式 I 的杂环衍生物具有很高的电子迁移率和很好的空穴阻滞性能，因此使用该杂环衍生物作为电子传输区材料，特别是空穴阻滞材料制备的有机电致发光器件具有低驱动电压和高发光效率的特点。有机电致发光器件还可以包括空穴传输区域，空穴传输区域，尤其是发射辅助层，包含式 II 的三芳基胺化合物。由于该器件的电子传输区和空穴传输区能够有效平衡载流子，从而减少了激子的淬灭，提高了载流子的重组概率，因此该器件具有低驱动电压和高发光效率的特点。
• TRIARYLAMINE DERIVATIVE AND ORGANIC ELECTROLUMINESCENT DEVICE THEREOF
  申请人：Changchun Hyperions Technology Co., Ltd.

  公开号：EP4101841A1

  公开（公告）日：2022-12-14

  Provided are a triarylamine derivative and an organic electroluminescent device thereof, which relate to the technical field of organic electroluminescence. The triarylamine derivative has a relatively high triplet energy level, high hole mobility, a high refractive index and good film formability and thermal stability and can effectively reduce the driving voltage of the organic electroluminescent device, improve the luminescence efficiency, and extend the service life of the device when applied to the organic electroluminescent device. The triarylamine derivative has a good application effect and a good industrialization prospect in the organic electroluminescent device.

  本发明提供了一种三芳基胺衍生物及其有机电致发光器件，涉及有机电致发光技术领域。该三芳基胺衍生物具有较高的三重能级、较高的空穴迁移率、较高的折射率以及良好的成膜性和热稳定性，应用于有机电致发光器件时，可有效降低有机电致发光器件的驱动电压，提高发光效率，延长器件的使用寿命。三芳基胺衍生物在有机电致发光器件中具有良好的应用效果和产业化前景。
• US8957219B2
  申请人：——

  公开号：US8957219B2

  公开（公告）日：2015-02-17
• Nickel-Catalyzed Coupling of Thiomethyl-Substituted 1,3-Benzothiazoles with Secondary Alkyl Grignard Reagents
  作者：Arash Ghaderi、Takanori Iwasaki、Asuka Fukuoka、Jun Terao、Nobuaki Kambe

  DOI：10.1002/chem.201203413

  日期：2013.2.25