(3S)-4'-bis(2,6-dimethylphenyl)phosphanyl-3,3'-spirobi[1,2-dihydroindene]-4-carbonitrile

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (3S)-4'-bis(2,6-dimethylphenyl)phosphanyl-3,3'-spirobi[1,2-dihydroindene]-4-carbonitrile
• 化学式: C₃₄H₃₂NP
• 分子量: 485.6
• InChiKey: ARHHDJCXXAHDRK-UMSFTDKQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.7
• 重原子数：
  36
• 可旋转键数：
  3
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  23.8
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• Spirobenzylamine-Phosphine, Preparation Method Therefor And Use Thereof
  申请人：Zhou Qilin

  公开号：US20140194638A1

  公开（公告）日：2014-07-10

  The present invention relates to a spirobenzylamine-phosphine, preparation method therefor and use thereof. The compound has a structure represented by formula (I), wherein n=0 to 3; R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 and R 9 having a value as defined in claim 1 . Starting from the substituted 7-trifluoromesyloxy-7′-diarylphosphino-1,1′-spiro-dihydroindene, the compound is synthesized in a two-step or three-step reactions. The new spirobenzylamine-phosphine is complexed with an iridium precursor and is subjected to ion exchange, to give an Iridium/spirobenzylamine-phosphine complex comprising various anions. The spiro benzyl amine-phosphine/Iridium complex according to the present invention may be used for catalyzing asymmetry hydrogenation of a variety of alpha-substituted acrylic acids, has high activity and enantio-selectivity, and has a good prospect of industrialization.

  本发明涉及一种螺环苄胺-膦化合物，其制备方法及用途。该化合物具有如下式（I）所表示的结构，其中n=0至3；R1、R2、R3、R4、R5、R6、R7、R8和R9具有如权利要求1中定义的值。从取代的7-三氟甲烯氧基-7'-二芳基膦基-1,1'-螺二氢茚出发，该化合物经过两步或三步反应合成。新的螺环苄胺-膦化合物与铱前体络合，并经过离子交换，得到包含各种阴离子的铱/螺环苄胺-膦络合物。根据本发明的螺环苄胺-膦/铱络合物可用于催化多种α-取代丙烯酸的不对称加氢，具有高活性和对映选择性，并具有良好的工业化前景。
• SPIROBENZYLAMINE-PHOSPHINE, PREPARATION METHOD THEREFOR AND USE THEREOF
  申请人：Zhejiang Jiuzhou Pharmaceutical Co., Ltd.

  公开号：EP2752419A1

  公开（公告）日：2014-07-09

  The present invention relates to a spirobenzylamine-phosphine, preparation method therefor and use thereof. The compound has a structure represented by formula (I), wherein n=0 to 3; R1, R2, R3, R4, R5, R6, R7, R8 and R9 having a value as defined in claim 1. Starting from the substituted 7-trifluoromesyloxy-7'-diarylphosphino-1, 1'-spiro-dihydroindene, the compound is synthesized in a two-step or three-step reactions. The new spirobenzylamine-phosphine is complexed with an iridium precursor and is subjected to ion exchange, to give an Iridium/spirobenzylamine-phosphine complex comprising various anions. The spiro benzyl amine-phosphine/Iridium complex according to the present invention may be used for catalyzing asymmetry hydrogenation of a variety of alpha-substituted acrylic acids, has high activity and enantio-selectivity, and has a good prospect of industrialization.

  本发明涉及一种螺苄胺膦及其制备方法和用途。该化合物具有式（I）所代表的结构，其中 n=0 至 3；R1、R2、R3、R4、R5、R6、R7、R8 和 R9 的值如权利要求 1 所定义。从取代的 7-三氟甲酰氧基-7'-二叔基膦-1，1'-螺二氢茚开始，通过两步或三步反应合成化合物。新的螺苄胺膦与铱前体络合，然后进行离子交换，得到由各种阴离子组成的铱/螺苄胺膦络合物。本发明的螺苄胺-膦/铱络合物可用于催化多种α-取代丙烯酸的不对称氢化反应，具有高活性和对映选择性，具有良好的工业化前景。
• US9108995B2
  申请人：——

  公开号：US9108995B2

  公开（公告）日：2015-08-18