2-[3-(Dimethylamino)-6-methylidenexanthen-9-yl]-4-[[4-[[8-(hydroxyamino)-8-oxooctanoyl]amino]phenyl]methylcarbamoyl]benzoic acid

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-[3-(Dimethylamino)-6-methylidenexanthen-9-yl]-4-[[4-[[8-(hydroxyamino)-8-oxooctanoyl]amino]phenyl]methylcarbamoyl]benzoic acid
• 英文别名: 2-[3-(dimethylamino)-6-methylidenexanthen-9-yl]-4-[[4-[[8-(hydroxyamino)-8-oxooctanoyl]amino]phenyl]methylcarbamoyl]benzoic acid
• 化学式: C₃₉H₄₀N₄O₇
• 分子量: 676.8
• InChiKey: YVZFUZSCUXBANR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  50
• 可旋转键数：
  14
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  157
• 氢给体数：
  5
• 氢受体数：
  8

文献信息

• RECOGNITION OF CELLULAR TARGET BINDING BY A BIOACTIVE AGENT USING INTRACELLULAR BIOLUMINESCENCE RESONANCE ENERGY TRANSFER
  申请人：Promega Corporation

  公开号：US20140194307A1

  公开（公告）日：2014-07-10

  The present invention provides compositions and methods for detection and analysis of intracellular binding of a bioactive agent to a cellular target. In particular, provided herein are bioactive agents tethered to fluorophores, cellular targets fused to bioluminescent reporters, or portions, components, or subunits of bioluminescent reporters, and methods of detecting and analyzing the interaction of bioactive agents with cellular targets therewith.

  本发明提供了一种检测和分析生物活性物质与细胞靶标内部结合的组合物和方法。具体而言，提供了生物活性物质与荧光染料相结合，细胞靶标与生物发光报告基因融合，或生物发光报告基因的部分、组分或亚单位，以及检测和分析生物活性物质与细胞靶标交互作用的方法。
• PHOTOAFFINITY PROBES
  申请人：Promega Corporation

  公开号：US20200340982A1

  公开（公告）日：2020-10-29

  Provided herein are compositions and methods for photoaffinity labeling of molecular targets. In particular, probes that specifically interact with cellular targets based on their affinity and are then covalently linked to the cellular target via a photoreactive group (PRG) on the probe.