(4S)-3-(3-methylpentan-3-yl)-4-propan-2-yl-1,3-oxazolidin-2-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 英文名称: (4S)-3-(3-methylpentan-3-yl)-4-propan-2-yl-1,3-oxazolidin-2-one
• 化学式: C₁₂H₂₃NO₂
• 分子量: 213.32
• InChiKey: AVFMVWMUXMQGDH-SNVBAGLBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  29.5
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• [EN] PROCESS FOR THE PREPARATION OF A FLUOROLACTON DERIVATIVE<br/>[FR] PROCÉDÉ DE PRÉPARATION D'UN DÉRIVÉ DE FLUOROLACTONE
  申请人：HOFFMANN LA ROCHE

  公开号：WO2014108525A1

  公开（公告）日：2014-07-17

  A novel process for the preparation of a fluorolactone derivative of the formula (I) and of its acylated derivative of formula (V) wherein R1 stands for a hydroxy protecting group is described. The acylated fluorolactones of formula (V), particularly the benzoyl derivative with R1 =benzyl are important precursors for the synthesis of prodrug compounds which have the potential to be potent inhibitors of the Hepatitis C Virus (HCV) NS5B polymerase.

  描述了一种制备公式（I）的氟内酯衍生物和其酰化衍生物的新工艺，其中R1代表一个羟基保护基团。公式（V）的酰化氟内酯，特别是R1 =苄基的苯甲酰衍生物，是合成前药化合物的重要前体，这些前药化合物具有潜力成为对丙型肝炎病毒（HCV）NS5B聚合酶具有强效抑制作用的化合物。
• PROCESS FOR THE PREPARATION OF A FLUOROLACTON DERIVATIVE
  申请人：Hoffmann-La Roche Inc.

  公开号：US20150315165A1

  公开（公告）日：2015-11-05

  A novel process for the preparation of a fluorolactone derivative of the formula and of its acylated derivative of formula wherein R 1 stands for a hydroxy protecting group is described. The acylated fluorolactones of formula V, particularly the benzoyl derivative with R 1 =benzyl are important precursors for the synthesis of prodrug compounds which have the potential to be potent inhibitors of the Hepatitis C Virus (HCV) NS5B polymerase.

  一种制备氟内酯衍生物的新工艺被描述，其化学式为，以及其酰化衍生物的化学式为，其中R1代表一个羟基保护基团。化学式为V的酰化氟内酯衍生物，特别是具有R1=苄基的苯甲酰衍生物，是合成前药化合物的重要前体，这些前药化合物具有成为HCV NS5B聚合酶的强效抑制剂的潜力。
• PROCESS FOR THE PREPARATION OF A FLUOROLACTION DERIVATIVE
  申请人：Gilead Pharmasset LLC

  公开号：US20170183317A1

  公开（公告）日：2017-06-29

  A novel process for the preparation of a fluorolactone derivative of the formula and of its acylated derivative of formula wherein R 1 stands for a hydroxy protecting group is described. The acylated fluor lactones of formula V, particularly the benzoyl derivative with R 1 =benzyl are important precursors for the synthesis of prodrug compounds which have the potential to be potent inhibitors of the Hepatitis C Virus (HCV) NS5B polymerase.