5-(5-chloropyridin-3-yl)-N-[(6-methoxy-5-methylpyridin-2-yl)methyl]-2-pyridin-2-ylpyridine-3-carboxamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 5-(5-chloropyridin-3-yl)-N-[(6-methoxy-5-methylpyridin-2-yl)methyl]-2-pyridin-2-ylpyridine-3-carboxamide
• 化学式: C₂₄H₂₀ClN₅O₂
• 分子量: 445.9
• InChiKey: JKZZEUIRMVNNGQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  32
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  89.9
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• USE OF INORGANIC MATRIX AND ORGANIC POLYMER COMBINATIONS FOR PREPARING STABLE AMORPHOUS DISPERSIONS
  申请人：Higgins John

  公开号：US20140206717A1

  公开（公告）日：2014-07-24

  The present invention relates to methods for processing pharmaceutically active substances having poor water solubility in the presence of an inorganic matrix, e.g., magnesium aluminometasilicate, and a secondary polymer as a means of converting the crystalline API to substantially amorphous and stable form, i.e., the crystallinity is less than 5%. The methods of the invention result in more complete amorphization, increased solubility, drug loading and stability as compared to typical amorphization or literature methods.