(2,5-Dioxopyrrolidin-1-yl) 3-[3-[3-(2,5-dioxopyrrol-1-yl)propanoylamino]propoxy]propanoate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: (2,5-Dioxopyrrolidin-1-yl) 3-[3-[3-(2,5-dioxopyrrol-1-yl)propanoylamino]propoxy]propanoate
• 英文别名: (2,5-dioxopyrrolidin-1-yl) 3-[3-[3-(2,5-dioxopyrrol-1-yl)propanoylamino]propoxy]propanoate
• 化学式: C₁₇H₂₁N₃O₈
• 分子量: 395.4
• InChiKey: FHLPIJOCAYLMKD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.1
• 重原子数：
  28
• 可旋转键数：
  12
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  139
• 氢给体数：
  1
• 氢受体数：
  8

文献信息

• HAPTENS OF PALIPERIDONE
  申请人：Ortho-Clinical Diagnostics, Inc.

  公开号：US20140213767A1

  公开（公告）日：2014-07-31

  The invention relates to compounds of Formula I, wherein L 1 , L 2 , and L 3 are defined in the specification, useful for the synthesis of novel conjugates and immunogens derived from paliperidone. The invention also relates to conjugates of a paliperidone hapten and a protein.

  本发明涉及式I的化合物，其中L1、L2和L3在规范中定义，用于合成源自帕利哌酮的新型结合物和免疫原。本发明还涉及帕利哌酮半抗原和蛋白质的结合物。
• Hetero type monodispersed polyethylene glycol, intermediate for production of hetero type monodispersed polyethylene glycol, methods for producing same, and hetero type monodispersed polyethylene glycol conjugate
  申请人：TOHOKU TECHNO ARCH CO., LTD.

  公开号：US10435509B2

  公开（公告）日：2019-10-08

  A hetero type monodispersed polyethylene glycol containing a compound represented by the following formula (1): NH2—(CH2CH2O)a—CH2CH2COOH  (1) (in the formula (1), a represents an integer from 6 to 40); wherein any of (A) a chromatogram detected by a differential refractometer when the hetero type monodispersed polyethylene glycol is separated using reverse phase chromatography, (B) a chromatogram detected by a differential refractometer when the hetero type monodispersed polyethylene glycol is separated using cation exchange chromatography, and (C) a chromatogram detected by a differential refractometer when the hetero type monodispersed polyethylene glycol containing a compound represented by the formula (1) shown above is derivatized and separated using anion exchange chromatography satisfy specific relational expressions, respectively.

  含有下式(1)所代表化合物的杂化型单分散聚乙二醇： NH2-(CH2CH2O)a-CH2CH2COOH (1) 式（1）中，a 代表 6 至 40 之间的整数）； 其中 (A) 使用反相色谱法分离异型单分散聚乙二醇时由差示折光仪检测到的色谱图，(B) 使用阳离子交换色谱法分离异型单分散聚乙二醇时由差示折光仪检测到的色谱图、(C) 当含有上述式(1)所代表化合物的杂类单分散聚乙二醇被衍生化并使用阴离子交换色谱分离时，由差示折射仪检测到的色谱图分别满足特定的关系表达式。
• US9394354B2
  申请人：——

  公开号：US9394354B2

  公开（公告）日：2016-07-19