Methyl 3-(4-methylbenzoyl)naphthalene-2-carboxylate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Methyl 3-(4-methylbenzoyl)naphthalene-2-carboxylate
• 英文别名: methyl 3-(4-methylbenzoyl)naphthalene-2-carboxylate
• 化学式: C₂₀H₁₆O₃
• 分子量: 304.3
• InChiKey: ITWUVTYCRJSOIW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  43.4
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• Suppression of prostate cancer using a targeted clostridial neurotoxin
  申请人：IPSEN BIOINNOVATION LIMITED

  公开号：US10550377B2

  公开（公告）日：2020-02-04

  The present invention relates to a method for suppressing or treating cancer, in particular to a method for suppressing or treating one or more of colorectal cancer, breast cancer, prostate cancer and/or lung cancer. The therapy employs use of a non-cytotoxic protease, which is targeted to a growth hormone-secreting cell such as to a pituitary cell. When so delivered, the protease is internalised and inhibits secretion/transmission of growth hormone from said cell. The present invention also relates to polypeptides and nucleic acids for use in said methods.

  本发明涉及一种抑制或治疗癌症的方法，特别是一种抑制或治疗结直肠癌、乳腺癌、前列腺癌和/或肺癌中的一种或多种癌症的方法。该疗法采用非细胞毒性蛋白酶，靶向生长激素分泌细胞，如垂体细胞。蛋白酶被输送后，会被内化并抑制所述细胞分泌/传递生长激素。本发明还涉及用于上述方法的多肽和核酸。
• SUPPRESSION OF CANCERS
  申请人：Syntaxin Limited

  公开号：US20140219983A1

  公开（公告）日：2014-08-07

  The present invention relates to a method for suppressing or treating cancer, in particular to a method for suppressing or treating one or more of colorectal cancer, breast cancer, prostate cancer and/or lung cancer. The therapy employs use of a non-cytotoxic protease, which is targeted to a growth hormone-secreting cell such as to a pituitary cell. When so delivered, the protease is internalised and inhibits secretion/transmission of growth hormone from said cell. The present invention also relates to polypeptides and nucleic acids for use in said methods.