N-(4-bromophenyl)-6-hexyl-7-hydroxy-2-oxo-2H-chromene-3-carboxamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(4-bromophenyl)-6-hexyl-7-hydroxy-2-oxo-2H-chromene-3-carboxamide
• 英文别名: N-(4-bromophenyl)-6-hexyl-7-hydroxy-2-oxochromene-3-carboxamide
• 化学式: C₂₂H₂₂BrNO₄
• 分子量: 444.3
• InChiKey: NCQXBPRUJUYUEL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.3
• 重原子数：
  28
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  75.6
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• [EN] COMPOSITIONS AND METHODS FOR TREATING MYOTONIC DYSTROPHY TYPE 1<br/>[FR] COMPOSITIONS ET PROCÉDÉS POUR LE TRAITEMENT DE LA DYSTROPHIE MYOTONIQUE DE TYPE 1
  申请人：UNIV SOUTHERN CALIFORNIA

  公开号：WO2014028025A1

  公开（公告）日：2014-02-20

  Disclosed is a compound for treatment of Myotonic Dystrophy type 1 having the formula (I) wherein X is selected from the group consisting of O, N, C, or S, Y is a homo- or heteroatomic 5-membered ring comprising one or more atoms selected from the group consisting of N, O, S, and C, Z is an optionally substituted aryl group or optionally substituted heteroaryl, including but not limited to halogenated benzenes, pyridines, substituted benzene, substituted pyridine, R2 = hydroxy, acyl, alkoxyl, esters, ethers, cyclic ethers, and lactones, R3 = H, alkyl, an optionally substituted alkyl, aliphatic ether, ester, cyclic unsaturated and aromatic ring groups, and R1, R4 and R5 are independently selected from the group consisting of hydrogen, halogen, alkyl, and alkoxyl or a pharmaceutically or cosmetically acceptable salt, solvate, or hydrate thereof.

  揭示了一种用于治疗肌萎缩性肌病类型1的化合物，其化学式为(I)，其中X选自O、N、C或S组成的群，Y是一个包括来自N、O、S和C组成的一个或多个原子的同核或异核5元环，Z是一个可选择取代的芳基团或可选择取代的杂环烃基，包括但不限于卤代苯、吡啶、取代苯、取代吡啶，R2 = 羟基、酰基、烷氧基、酯、醚、环醚和内酯，R3 = H、烷基、可选择取代的烷基、脂肪醚、酯、环烯烃和芳香环基，而R1、R4和R5独立地选自氢、卤素、烷基和烷氧基或其药学上或化妆上可接受的盐、溶剂化合物或水合物。
• Compositions and Methods for Treating Myotonic Dystrophy Type 1
  申请人：REDDY Sita

  公开号：US20140051709A1

  公开（公告）日：2014-02-20

  Disclosed is a compound for treatment of Myotonic Dystrophy type 1 having the formula: Wherein X is selected from the group consisting of O, N, C, or S, Y is a homo- or heteroatomic 5-membered ring comprising one or more atoms selected from the group consisting of N, O, S, and C, Z is an optionally substituted aryl group or optionally substituted heteroaryl, including but not limited to halogenated benzenes, pyridines, substituted benzene, substituted pyridine, R 2 =hydroxy, acyl, alkoxyl, esters, ethers, cyclic ethers, and lactones, R 3 =H, alkyl, an optionally substituted alkyl, aliphatic ether, ester, cyclic unsaturated and aromatic ring groups, and R 1 , R 4 and R 5 are independently selected from the group consisting of hydrogen, halogen, alkyl, and alkoxyl or a pharmaceutically or cosmetically acceptable salt, solvate, or hydrate thereof.

  揭示了一种用于治疗肌萎缩性肌病型1的化合物，其化学式为：其中X选自O、N、C或S组成的群，Y是一个由N、O、S和C组成的原子选自的同源或异源5-成员环，Z是一个可选择取代的芳基或可选择取代的杂环烃基，包括但不限于卤代苯、吡啶、取代苯、取代吡啶，R2=羟基、酰基、烷氧基、酯、醚、环醚和内酯，R3=H、烷基、一个可选择取代的烷基、脂肪醚、酯、环状不饱和和芳香环基，R1、R4和R5独立选自氢、卤素、烷基和烷氧基或其药学上或化妆品上可接受的盐、溶剂合物或水合物。