N-(1-benzoylpiperidin-4-yl)-2-(6-chloropyridazin-3-yl)oxy-N-methylacetamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(1-benzoylpiperidin-4-yl)-2-(6-chloropyridazin-3-yl)oxy-N-methylacetamide
• 化学式: C₁₉H₂₁ClN₄O₃
• 分子量: 388.8
• InChiKey: UNZJVJNZXVXLRI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  27
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  75.6
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• NITROGEN-CONTAINING SIX-MEMBERED AROMATIC RING DERIVATIVES AND PHARMACEUTICAL PRODUCTS CONTAINING THE SAME
  申请人：Daiichi Sankyo Company, Limited

  公开号：US20140221409A1

  公开（公告）日：2014-08-07

  Provided is a compound that has the ability to promote axonal outgrowth in combination with the ability to promote angiogenesis and can therefore be used to reduce central nerve injuries such as head injury and spinal cord injury, cerebral infarction, ischemic heart diseases such as myocardial infarction and organic angina, peripheral arterial occlusive diseases such as critical limb ischemia, or after-effects of these diseases. Specifically, the compound is represented by the following formula (I): in which Nx group is preferably a 6-membered aromatic ring containing two nitrogen atoms; R 0 , R 1 and R 2 are each independently a hydrogen atom, an alkyl group, an amino group or the like; E is an oxygen atom or an —NR 8 group (wherein R 8 is an alkyl group or the like); n is an integer of 0 to 5; X and Y are each a connecting bond, a cycloalkyl group, —CO— or the like; and Q is a hydrogen atom or a phenyl group.

  提供的化合物具有促进轴突生长和促进血管生成的能力，因此可用于减轻中枢神经损伤，如头部损伤和脊髓损伤，脑梗塞，缺血性心脏病如心肌梗死和器质性心绞痛，周围动脉闭塞性疾病如严重肢体缺血或这些疾病的后遗症。具体而言，该化合物由以下式（I）表示：其中Nx基团最好是含有两个氮原子的6元芳香环；R0、R1和R2分别独立地是氢原子、烷基、氨基或类似物；E是氧原子或-NR8基团（其中R8是烷基或类似物）；n为0至5的整数；X和Y分别是连接键、环烷基、-CO-或类似物；Q是氢原子或苯基。
• US9139559B2
  申请人：——

  公开号：US9139559B2

  公开（公告）日：2015-09-22