4-amino-5-chloro-3-fluoro-6'-(trifluoromethyl)-[2,3'-bipyridine]-6-carbaldehyde | 1613459-89-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 4-amino-5-chloro-3-fluoro-6'-(trifluoromethyl)-[2,3'-bipyridine]-6-carbaldehyde
• 英文别名: 4-Amino-5-chloro-3-fluoro-6'-(trifluoromethyl)-[2,3'-bipyridine]-6-carbaldehyde；4-amino-3-chloro-5-fluoro-6-[6-(trifluoromethyl)pyridin-3-yl]pyridine-2-carbaldehyde
• CAS: 1613459-89-4
• 化学式: C₁₂H₆ClF₄N₃O
• 分子量: 319.646
• InChiKey: DIEBXBXLZLZXBV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  68.9
• 氢给体数：
  1
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  1,3-二氯-5,5-二甲基海因 、 4-amino-3-fluoro-6'-(trifluoromethyl)-[2,3'-bipyridine]-6-carbaldehyde 以 乙腈 为溶剂， 以gave 4-amino-5-chloro-3-fluoro-6′-(trifluoromethyl)-[2,3′-bipyridine]-6-carbaldehyde (182 mg, 69.8%) as a yellow solid的产率得到4-amino-5-chloro-3-fluoro-6'-(trifluoromethyl)-[2,3'-bipyridine]-6-carbaldehyde
  参考文献：
  名称：

  PROCESSES FOR THE PREPARATION OF 4-AMINO-3-HALO-6-(SUBSTITUTED)PICOLINATES AND 4-AMINO-5-FLUORO-3-HALO-6-(SUBSTITUTED)PICOLINATES

  摘要：

  4-氨基-3-氯-6-(取代基)吡啶酸盐是通过以下一系列步骤从二氟乙酸或三氟乙酸、三苄基胺或叔丁基胺作为保护基、3,3-二烷氧基丙-1-炔和取代亚甲基胺制备而成。

  公开号：

  US20140171654A1

文献信息

• Processes for the preparation of 4-amino-3-halo-6-(substituted)picolinates and 4-amino-5-fluoro-3-halo-6-(substituted)picolinates
  申请人：Johnson Peter L.

  公开号：US09096526B2

  公开（公告）日：2015-08-04

  4-Amino-3-chloro-6-(substituted)picolinates are prepared from difluoroacetic acid or trifluoroacetic acid, tritylamine or t-butylamine as a protecting group, a 3,3-dialkoxyprop-1-yne and a substituted methylene amine by a series of steps.

  4-氨基-3-氯-6-(取代基)吡啶酸盐是通过一系列步骤从二氟乙酸或三氟乙酸、三苄基胺或叔丁基胺作为保护基、3,3-二烷氧基丙-1-炔和取代亚甲基胺制备而成。
• PROCESSES FOR THE PREPARATION OF 4-AMINO-3-HALO-6- (SUBSTITUTED)PICOLINATES AND 4-AMINO-5-FLUORO-3-HALO-6- (SUBSTITUTED)PICOLINATES
  申请人：Dow AgroSciences LLC

  公开号：EP2931044A1

  公开（公告）日：2015-10-21
• US9096526B2
  申请人：——

  公开号：US9096526B2

  公开（公告）日：2015-08-04
• [EN] PROCESSES FOR THE PREPARATION OF 4-AMINO-3-HALO-6- (SUBSTITUTED)PICOLINATES AND 4-AMINO-5-FLUORO-3-HALO-6- (SUBSTITUTED)PICOLINATES<br/>[FR] PROCÉDÉS POUR LA PRÉPARATION DE 4-AMINO-3-HALO-6-(SUBSTITUÉS)PICOLINATES ET DE 4-AMINO-5-FLUORO-3-HALO-6 SUBSTITUÉS-PICOLINATES
  申请人：DOW AGROSCIENCES LLC

  公开号：WO2014093591A1

  公开（公告）日：2014-06-19

  4-Amino-3-chloro-6-(substituted)picolinates are prepared from difluoroacetic acid or trifluoroacetic acid, tritylamine or t-butylamine as a protecting group, a 3,3-dialkoxyprop-1-yne and a substituted methylene amine by a series of steps. Provided herein are processes for the preparation of 4-amino-5-fluoro-3-halo-6-(substituted)picolinates and 4-amino-3-halo-6-(substituted)picolinates. More particularly, provided herein are processes for the preparation of 4-amino-5-fluoro-3-halo-6-(substituted)picolinates and 4-amino-3-halo-6- (substituted)picolinates from a non-pyridine source. These picolinates are useful as herbicides.