2-(2-propan-2-ylphenyl)-3-[4-[(E)-2-(5-propyl-1,3,4-oxadiazol-2-yl)ethenyl]cyclohexa-1,5-dien-1-yl]oxy-1-benzothiophen-6-ol

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(2-propan-2-ylphenyl)-3-[4-[(E)-2-(5-propyl-1,3,4-oxadiazol-2-yl)ethenyl]cyclohexa-1,5-dien-1-yl]oxy-1-benzothiophen-6-ol
• 化学式: C₃₀H₃₀N₂O₃S
• 分子量: 498.6
• InChiKey: FAKLZQVOWWTKRN-SFQUDFHCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8
• 重原子数：
  36
• 可旋转键数：
  8
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  96.6
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• [EN] BENZOTHIOPHENE DERIVATIVES AND COMPOSITIONS THEREOF AS SELECTIVE ESTROGEN RECEPTOR DEGRADERS<br/>[FR] DÉRIVÉS DE BENZOTHIOPHÈNE ET COMPOSITIONS CORRESPONDANTES EN TANT QU'AGENTS DE DÉGRADATION SÉLECTIFS DES RÉCEPTEURS DES ŒSTROGÈNES
  申请人：NOVARTIS AG

  公开号：WO2014130310A1

  公开（公告）日：2014-08-28

  The present invention relates to compounds of formula I: in which n, m, X, Y1, R1, R2, R3, R4 and R5 are defined in the Summary of the Invention; capable of being both potent antagonists and degraders of estrogen receptors. The invention further provides a process for the preparation of compounds of the invention, pharmaceutical preparations comprising such compounds and methods of using such compounds and compositions in the management of diseases or disorders associated with aberrant estrogen receptor activity.